ABRAHAO FONTES BAPTISTA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/54 - Laboratório de Bacteriologia, Hospital das Clínicas, Faculdade de Medicina
LIM/54 - Laboratório de Bacteriologia, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
- Applications of Non-invasive Neuromodulation for the Management of Disorders Related to COVID-19(2020) BAPTISTA, Abrahao Fontes; BALTAR, Adriana; OKANO, Alexandre Hideki; MOREIRA, Alexandre; CAMPOS, Ana Carolina Pinheiro; FERNANDES, Ana Mercia; BRUNONI, Andre Russowsky; BADRAN, Bashar W.; TANAKA, Clarice; ANDRADE, Daniel Ciampi de; MACHADO, Daniel Gomes da Silva; MORYA, Edgard; TRUJILLO, Eduardo; SWAMI, Jaiti K.; CAMPRODON, Joan A.; MONTE-SILVA, Katia; SA, Katia Nunes; NUNES, Isadora; GOULARDINS, Juliana Barbosa; BIKSON, Marom; SUDBRACK-OLIVEIRA, Pedro; CARVALHO, Priscila de; DUARTE-MOREIRA, Rafael Jardim; PAGANO, Rosana Lima; SHINJO, Samuel Katsuyuki; ZANA, YossiBackground: Novel coronavirus disease (COVID-19) morbidity is not restricted to the respiratory system, but also affects the nervous system. Non-invasive neuromodulation may be useful in the treatment of the disorders associated with COVID-19. Objective: To describe the rationale and empirical basis of the use of non-invasive neuromodulation in the management of patients with COVID-10 and related disorders. Methods: We summarize COVID-19 pathophysiology with emphasis of direct neuroinvasiveness, neuroimmune response and inflammation, autonomic balance and neurological, musculoskeletal and neuropsychiatric sequela. This supports the development of a framework for advancing applications of non-invasive neuromodulation in the management COVID-19 and related disorders. Results: Non-invasive neuromodulation may manage disorders associated with COVID-19 through four pathways: (1) Direct infection mitigation through the stimulation of regions involved in the regulation of systemic anti-inflammatory responses and/or autonomic responses and prevention of neuroinflammation and recovery of respiration; (2) Amelioration of COVID-19 symptoms of musculoskeletal pain and systemic fatigue; (3) Augmenting cognitive and physical rehabilitation following critical illness; and (4) Treating outbreak-related mental distress including neurological and psychiatric disorders exacerbated by surrounding psychosocial stressors related to COVID-19. The selection of the appropriate techniques will depend on the identified target treatment pathway. Conclusion: COVID-19 infection results in a myriad of acute and chronic symptoms, both directly associated with respiratory distress (e.g., rehabilitation) or of yet-to-be-determined etiology (e.g., fatigue). Non-invasive neuromodulation is a toolbox of techniques that based on targeted pathways and empirical evidence (largely in non-COVID-19 patients) can be investigated in the management of patients with COVID-19.
- Update on the Use of Transcranial Electrical Brain Stimulation to Manage Acute and Chronic COVID-19 Symptoms(2020) PILLONI, Giuseppina; BIKSON, Marom; BADRAN, Bashar W.; GEORGE, Mark S.; KAUTZ, Steven A.; OKANO, Alexandre Hideki; BAPTISTA, Abrahao Fontes; CHARVET, Leigh E.The coronavirus disease 19 (COVID-19) pandemic has resulted in the urgent need to develop and deploy treatment approaches that can minimize mortality and morbidity. As infection, resulting illness, and the often prolonged recovery period continue to be characterized, therapeutic roles for transcranial electrical stimulation (tES) have emerged as promising non-pharmacological interventions. tES techniques have established therapeutic potential for managing a range of conditions relevant to COVID-19 illness and recovery, and may further be relevant for the general management of increased mental health problems during this time. Furthermore, these tES techniques can be inexpensive, portable, and allow for trained self-administration. Here, we summarize the rationale for using tES techniques, specifically transcranial Direct Current Stimulation (tDCS), across the COVID-19 clinical course, and index ongoing efforts to evaluate the inclusion of tES optimal clinical care.
- Effect of Transcranial Direct Current Stimulation on Professional Female Soccer Players' Recovery Following Official Matches(2021) MOREIRA, Alexandre; MACHADO, Daniel Gomes da Silva; BIKSON, Marom; UNAL, Gozde; BRADLEY, Paul S.; MOSCALESKI, Luciane; COSTA, Taline; KALIL, Gabriella C. S. G.; CHAO, Liaw W.; BAPTISTA, Abrahao F.; MORYA, Edgard; OKANO, Alexandre H.This study investigated the effect of transcranial direct current stimulation (tDCS) combined with a recovery training session on the well-being and self-perceived recovery of professional female soccer players after official matches. Data from 13 world-class players were analyzed after participating in four official soccer matches of the first division of the Brazilian Women's Soccer Championship (7-, 10-, and 13-day intervals). We applied anodal tDCS (a-tDCS) over the left dorsolateral prefrontal cortex with 2 mA for 20 minutes (+F3/-F4 montage) the day after each match. Participants underwent two randomly ordered sessions of a-tDCS or sham. Players completed the Well-Being Questionnaire (WBQ) and the Total Quality Recovery (TQR) scale before each experimental condition and again the following morning. A two-way repeated-measures ANOVA showed a significant time x condition interaction on the WBQ (F-(1,F-11)=5.21; p=0.043; eta(2)(p)=0.32), but not on the TQR (F-(1,F-12) = 0.552; p = 0.47; eta(2)(p) = 0.044). There was a large effect size (ES) for a-tDCS for the WBQ score (ES = 1.02; 95%CI = 0.17;1.88), and there was a moderate WBQ score increase (ES = 0.53; 95%CI = -0.29;1.34) for the sham condition. We found similar increases in the TQR score for a-tDCS (ES = 1.50; 95%CI = 0.63-2.37) and the sham condition (ES = 1.36; 95%CI = 0.51-2.22). These results suggest that a-tDCS (+F3/-F4 montage) combined with a recovery training session may slightly improve perceived well-being beyond the level of improvement after only the recovery training session among world-class female soccer players. Prior to widely adopting this recovery approach, further study is needed with larger and more diverse samples, including for female teams of different performance levels.
- Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes(2019) MORYA, Edgard; MONTE-SILVA, Katia; BIKSON, Marom; ESMAEILPOUR, Zeinab; BIAZOLI JR., Claudinei Eduardo; FONSECA, Andre; BOCCI, Tommaso; FARZAN, Faranak; CHATTERJEE, Raaj; HAUSDORFF, Jeffrey M.; MACHADO, Daniel Gomes da Silva; BRUNONI, Andre Russowsky; MEZGER, Eva; MOSCALESKI, Luciane Aparecida; PEGADO, Rodrigo; SATO, Joao Ricardo; CAETANO, Marcelo Salvador; SA, Katia Nunes; TANAKA, Clarice; LI, Li Min; BAPTISTA, Abrahao Fontes; OKANO, Alexandre HidekiTranscranial Direct Current Stimulation (tDCS) is a non-invasive technique used to modulate neural tissue. Neuromodulation apparently improves cognitive functions in several neurologic diseases treatment and sports performance. In this study, we present a comprehensive, integrative review of tDCS for motor rehabilitation and motor learning in healthy individuals, athletes and multiple neurologic and neuropsychiatric conditions. We also report on neuromodulation mechanisms, main applications, current knowledge including areas such as language, embodied cognition, functional and social aspects, and future directions. We present the use and perspectives of new developments in tDCS technology, namely high-definition tDCS (HD-tDCS) which promises to overcome one of the main tDCS limitation (i.e., low focality) and its application for neurological disease, pain relief, and motor learning/rehabilitation. Finally, we provided information regarding the Transcutaneous Spinal Direct Current Stimulation (tsDCS) in clinical applications, Cerebellar tDCS (ctDCS) and its influence on motor learning, and TMS combined with electroencephalography (EEG) as a tool to evaluate tDCS effects on brain function.