HO YEH LI
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/54 - Laboratório de Bacteriologia, Hospital das Clínicas, Faculdade de Medicina
LIM/54 - Laboratório de Bacteriologia, Hospital das Clínicas, Faculdade de Medicina
15 resultados
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bookPart Aids na UTI(2022) LI, Ho Yeh- Highly active antiretroviral therapy for critically ill HIV patients: A systematic review and meta-analysis(2017) ANDRADE, Hugo Boechat; SHINOTSUKA, Cassia Righy; SILVA, Ivan Rocha Ferreira da; DONINI, Camila Sunaitis; LI, Ho Yeh; CARVALHO, Frederico Bruzzi de; BRASIL, Pedro Emmanuel Alvarenga Americano do; BOZZA, Fernando Augusto; JAPIASSU, Andre MiguelIntroduction It is unclear whether the treatment of an HIV infection with highly active antiretroviral therapy (HAART) affects intensive care unit (ICU) outcomes. In this paper, we report the results of a systematic review and meta-analysis performed to summarize the effects of HAART on the prognosis of critically ill HIV positive patients. Materials and methods A bibliographic search was performed in 3 databases (PubMed, Web of Science and Scopus) to identify articles that investigated the use of HAART during ICU admissions for shortand long-term mortality or survival. Eligible articles were selected in a staged process and were independently assessed by two investigators. The methodological quality of the selected articles was evaluated using the Methodological Index for Non-Randomized Studies (MINORS) tool. Results Twelve articles met the systematic review inclusion criteria and examined short-term mortality. Six of them also examined long-term mortality (>= 90 days) after ICU discharge. The short-term mortality meta-analysis showed a significant beneficial effect of initiating or maintaining HAART during the ICU stay (random effects odds ratio 0.53, p = 0.02). The data analysis of long-term outcomes also suggested a reduced mortality when HAART was used, but the effect of HAART on long-term mortality of HIV positive critically ill patients remains uncertain. Conclusions This meta-analysis suggests improved survival rates for HIV positive patients who were treated with HAART during their ICU admission.
bookPart Aids na UTI(2023) LI, Ho Yeh- Follow-up after acute respiratory distress syndrome caused by influenza a (H1N1) virus infection(2011) TOUFEN JR., Carlos; COSTA, Eduardo Leite V.; HIROTA, Adriana Sayuri; LI, Ho Yeh; AMATO, Marcelo Brito Passos; CARVALHO, Carlos Roberto RibeiroBACKGROUND: There are no reports on the long-term follow-up of patients with swine-origin influenza A virus infection that progressed to acute respiratory distress syndrome. METHODS: Four patients were prospectively followed up with pulmonary function tests and high-resolution computed tomography for six months after admission to an intensive care unit. RESULTS: Pulmonary function test results assessed two months after admission to the intensive care unit showed reduced forced vital capacity in all patients and low diffusion capacity for carbon monoxide in two patients. At six months, pulmonary function test results were available for three patients. Two patients continued to have a restrictive pattern, and none of the patients presented with abnormal diffusion capacity for carbon monoxide. All of them had a diffuse ground-glass pattern on high-resolution computed tomography that improved after six months. CONCLUSIONS: Despite the marked severity of lung disease at admission, patients with acute respiratory distress syndrome caused by swine-origin influenza A virus infection presented a late but substantial recovery over six months of follow-up.
bookPart Doença infecciosa crônica terminal(2019) LI, Ho Yeh- Oxigenação por membrana extracorpórea para síndrome do desconforto respiratório agudo grave em pacientes adultos: revisão sistemática e metanálise(2019) MENDES, Pedro Vitale; MELRO, Livia Maria Garcia; LI, Ho Yeh; JOELSONS, Daniel; ZIGAIB, Rogerio; RIBEIRO, José Mauro da Fonseca Pestana; BESEN, Bruno Adler Maccagnan Pinheiro; PARK, MarceloABSTRACT Objective: The evidence of improved survival with the use of extracorporeal membrane oxygenation (ECMO) in acute respiratory distress syndrome is still uncertain. Methods: This systematic review and meta-analysis was registered in the PROSPERO database with the number CRD-42018098618. We performed a structured search of Medline, Lilacs, and ScienceDirect for randomized controlled trials evaluating the use of ECMO associated with (ultra)protective mechanical ventilation for severe acute respiratory failure in adult patients. We used the Cochrane risk of bias tool to evaluate the quality of the evidence. Our primary objective was to evaluate the effect of ECMO on the last reported mortality. Secondary outcomes were treatment failure, hospital length of stay and the need for renal replacement therapy in both groups. Results: Two randomized controlled studies were included in the meta-analysis, comprising 429 patients, of whom 214 were supported with ECMO. The most common reason for acute respiratory failure was pneumonia (60% - 65%). Respiratory ECMO support was associated with a reduction in last reported mortality and treatment failure with risk ratios (RR: 0.76; 95%CI 0.61 - 0.95 and RR: 0.68; 95%CI 0.55 - 0.85, respectively). Extracorporeal membrane oxygenation reduced the need for renal replacement therapy, with a RR of 0.88 (95%CI 0.77 - 0.99). Intensive care unit and hospital lengths of stay were longer in ECMO-supported patients, with an additional P50th 14.84 (P25th - P75th: 12.49 - 17.18) and P50th 29.80 (P25th - P75th: 26.04 - 33.56] days, respectively. Conclusion: Respiratory ECMO support in severe acute respiratory distress syndrome patients is associated with a reduced mortality rate and a reduced need for renal replacement therapy but a substantial increase in the lengths of stay in the intensive care unit and hospital. Our results may help bedside decision-making regarding ECMO initiation in patients with severe respiratory distress syndrome.
bookPart Aids na UTI(2015) LI, Ho Yeh- Summary of Evidence and Recommendations: Guidelines for Care of Critically Ill Adult Patients with COVID-19 in the Americas(2021) REVEIZ, Ludovic; TOLEDO, Joao; TORRES, Marcela; IZCOVICH, Ariel; BALBIN, Graciela Josefina; SA, Marcio Borges; LISBOA, Thiago Costa; CUELLAR, Gustavo Gabriel; JAIMES, Fabian; DELSO, Luis Antonio Gorordo; MEZA, Juan Carlos; RESTREPO, Sonia; RODRIGUEZ, Angel; SALAZAR, Leonardo; SOSA, Ojino; UBIERGO, Sebastian Ugarte; LI, Ho Yeh; MENDEZ, Jairo; FUENTE, Luis de la; CASTRO, Jose Luis; LEMGRUBEI, Alexandre; CACCAVO, Francisco; BELTRAN, Mauricio; PEIRIS, Sasha; PARDO, RodrigoIntroduction. In 2020, the World Health Organization declared the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has spread around the world. Approximately 5% of infected patients are critical cases that require admission to the intensive care unit (ICU). In these patients, COVID-19 can be complicated by acute respiratory distress syndrome, septic shock, and multi-organ failure, including kidney and heart failure. Objective. Summarize the recommendations included in the Guidelines for Care of Critically Ill Adult Patients with COVID-19 in the Americas, version 3, published by the Pan American Health Organization in 2021 to guide the management of critically ill adult patients with COVID-19 treated in the ICU, and address key aspects of implementation of the recommendations. Methodology. The guidelines and their recommendations were summarized. In addition, a systematic search was carried out in Pubmed, Lilacs, Health Systems Evidence, Epistemonikos, and gray literature on studies carried out in the Region of the Americas, in order to identify barriers, facilitators, and implementation strategies. Results. Forty-three recommendations are presented that address the identification of markers and risk factors for mortality, infection prevention and control, specimen collection, supportive care (ventilatory and hemodynamic), pharmacological treatment, early rehabilitation, use of imaging studies, prevention of complications, and discharge criteria for critical patients with COVID-19. Conclusions. The recommendations seek to provide knowledge on the management of critical patients with COVID-19 and offer considerations for implementation of the recommendations in the Region.
bookPart Hantavirose(2013) LI, Ho YehbookPart Aids na UTI(2018) LI, Ho Yeh