JEANE MIKE TSUTSUI
Projetos de Pesquisa
Unidades Organizacionais
10 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 10
- Prognostic value of dobutamine stress myocardial perfusion echocardiography in patients with known or suspected coronary artery disease and normal left ventricular function(2017) MATTOSO, Angele A. A.; TSUTSUI, Jeane M.; KOWATSCH, Ingrid; CRUZ, Vitoria Y. L.; SBANO, Joao C. N.; RIBEIRO, Henrique B.; KALIL FILHO, Roberto; PORTER, Thomas R.; MATHIAS JR., WilsonObjective We sought to determine the prognostic value of qualitative and quantitative analysis obtained by real-time myocardial perfusion echocardiography (RTMPE) in patients with known or suspected coronary artery disease (CAD). Background Quantification of myocardial blood flow reserve (MBFR) in patients with CAD using RTMPE has been demonstrated to further improve accuracy over the analysis of wall motion (WM) and qualitative analysis of myocardial perfusion (QMP). Methods From March 2003 to December 2008, we prospectively studied 168 patients with normal left ventricular function (LVF) who underwent dobutamine stress RTMPE. The replenishment velocity reserve (beta) and MBFR were derived from RTMPE. Acute coronary events were: cardiac death, myocardial infarction and unstable angina with need for urgent coronary revascularization. Results During a median follow-up of 34 months (5 days to 6.9 years), 17 acute coronary events occurred. Abnormal beta reserve in >= 2 coronary territories was the only independent predictor of events hazard ratio (HR) = 21, 95% CI = 4.5-99; p<0.001). Both, abnormal beta reserve and MBFR added significant incremental value in predicting events over qualitative analysis of WM and MP (chi(2) = 6.6 and chi(2) = 24.6, respectively; p = 0.001 and chi(2) = 6.6 and chi(2) = 15.5, respectively; p = 0.012, respectively). When coronary angiographic data was added to the multivariate analysis model, beta reserve remained the only predictor of events with HR of 21.0 (95% CI = 4.5-99); p<0.001. Conclusion Quantitative dobutamine stress RTMPE provides incremental prognostic information over clinical variables, qualitative analysis of WM and MP, and coronary angiography in predicting acute coronary events.
article 0 Citação(ões) na Scopus The clinical use of stress echocardiography in non-ischaemic heart disease: recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography (vol 17, 1191, 2016)(2017) LANCELLOTTI, Patrizio; PELLIKKA, Patricia A.; DULGHERU, Raluca; EDVARDSEN, Thor; GARBI, Madalina; HA, Jong Won; KREEGER, Joe; MERTENS, Luc; PICANO, Eugenio; RYAN, Thomas; TSUTSUI, Jeane M.; VARGA, Albert; BUDTS, Werner; CHAUDHRY, Farooq A.; DONAL, Erwan; KANE, Garvan C.; PIBAROT, Philippe- Indeterminate form of Chagas disease: is left ventricular torsional mechanics a clue to subclinical myocardial abnormalities?(2017) LIMA, Marcio Silva Miguel; VOOS, Mariana Callil; MATHIAS JR., Wilson; TSUTSUIL, Jeane MikeBackground Chagas disease (CD) is highly endemic in Latin America, and has been emerging in developed countries. Early diagnosis of left ventricular (LV) systolic dysfunction, routinely done by echocardiography, is crucial for therapy. Speckle tracking echocardiography allows determination of LV segmental rotations, twist/torsion, and this analysis may disclose an unapparent myocardial contractile deficit in initial stages of CD. Therefore, this study aimed to highlight a possible unapparent myocardial contractile deficit in CD indeterminate form (IF) by a comprehensive torsional mechanics analysis. Methods Patients with CDIF diagnosis, initial chagasic cardiomyopathy (CCMP characterized by ECG abnormalities and LVEF > 0.55), and normal controls were prospectively enrolled, and underwent conventional echocardiogram with images acquisition for STE offline analysis. Target parameters were basal and apical rotations, and calculation of twist and torsion. Results A total of 42 patients were included (CDIF, eight; CCMP, 13; and 21 controls). Chagasic patients had a mean age of 55 years, five (24 %) men, and controls, 50 years, seven (33 %) men. Torsional mechanics analyzes resulted in no significant difference in all parameters studied between groups. Twist in CDIF was 20.8A degrees A +/- 6.5A degrees; CCMP, 19.0A degrees A +/- 3.5A degrees and controls, 19.7A degrees A +/- 3.7A degrees (p = 0.67). Torsion in CDIF was 2.6A degrees A +/- 0.8A degrees; CCMP, 2.4A degrees A +/- 0.6A degrees and controls, 2.4A degrees A +/- 0.5A degrees (p = 0.63). Conclusion Patients with Chagas disease have no abnormalities in torsional mechanics during its indeterminate and initial cardiomyopathy stages.
- Allogeneic pASC transplantation in humanized pigs attenuates cardiac remodeling post-myocardial infarction(2017) DARIOLLI, Rafael; NAGHETINI, Marcus V.; MARQUES, Euclydes F.; TAKIMURA, Celso K.; JENSEN, Leonardo S.; KIERS, Bianca; TSUTSUI, Jeane M.; MATHIAS JR., Wilson; LEMOS NETO, Pedro A.; KRIEGER, Jose E.Cell therapy repair strategies using adult mesenchymal stromal cells have shown promising evidence to prevent cardiac deterioration in rodents even in the absence of robust differentiation of the cells into cardiomyocytes. We tested whether increasing doses of porcine adipose- tissue derived mesenchymal stem cells (pASCs) increase cardiac tissue perfusion in pigs post-myocardial infarction (MI) receiving angiotensin-converting-enzyme inhibitor (ACE inhibitors) and Beta-blockers similarly to patients. Female pigs were subjected to MI induction by sponge permanent occlusion of left circumflex coronary artery (LCx) generating approximately 10% of injured LV area with minimum hemodynamic impact. We assessed tissue perfusion by real time myocardial perfusion echocardiography (RTMPE) using commercial microbubbles before and following pASCs treatment. Four weeks after the occlusion of the left circumflex artery, we transplanted placebo or pASCs (1, 2 and 4x10 6 cells/Kg BW) into the myocardium. The highest dose of pASCs increased myocardial vessel number and blood flow in the border (56% and 3.7-fold, respectively) and in the remote area (54% and 3.9-fold, respectively) while the non-perfused scar area decreased (up to 38%). We also found an increase of immature collagen fibers, although the increase in total tissue collagen and types I and III was similar in all groups. Our results provide evidence that pASCsinduced stimulation of tissue perfusion and accumulation of immature collagen fibers attenuates adverse remodeling post-MI beyond the normal beneficial effects associated with ACE inhibition and beta-blockade.
- The Clinical Use of Stress Echocardiography in Non-Ischaemic Heart Disease: Recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography(2017) LANCELLOTTI, Patrizio; PELLIKKA, Patricia A.; BUDTS, Werner; CHAUDHRY, Farooq A.; DONAL, Erwan; DULGHERU, Raluca; EDVARDSEN, Thor; GARBI, Madalina; HA, Jong Won; KANE, Garvan C.; KREEGER, Joe; MERTENS, Luc; PIBAROT, Philippe; PICANO, Eugenio; RYAN, Thomas; TSUTSUI, Jeane M.; VARGA, AlbertA unique and highly versatile technique, stress echocardiography (SE) is increasingly recognized for its utility in the evaluation of non-ischaemic heart disease. SE allows for simultaneous assessment of myocardial function and haemodynamics under physiological or pharmacological conditions. Due to its diagnostic and prognostic value, SE has become widely implemented to assess various conditions other than ischaemic heart disease. It has thus become essential to establish guidance for its applications and performance in the area of non-ischaemic heart disease. This paper summarizes these recommendations.
- The clinical use of stress echocardiography in non-ischaemic heart disease: recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography (vol 17, pg 1191, 2016)(2017) LANCELLOTTI, Patrizio; PELLIKKA, Patricia A.; DULGHERU, Raluca; EDVARDSEN, Thor; GARBI, Madalina; HA, Jong Won; KREEGER, Joe; MERTENS, Luc; PICANO, Eugenio; RYAN, Thomas; TSUTSUI, Jeane M.; VARGA, Albert
conferenceObject Microbubble-Mediated Sonothrombolysis for Treatment of Patients With Acute St-Segment Elevation Myocardial Infarction: Improvement in Recanalization Rate, Systolic Function and Microvascular Perfusion(2017) MATHIAS, Wilson; TSUTSUI, Jeane M.; AGUIAR, Miguel O.; TAVARES, Bruno; NICOLAU, Jose; VIANA, Erica P.; OLIVEIRA, Mucio T.; SOEIRO, Alexandre; LEMOS, Pedro; LOPES, Bernardo; SBANO, Joao; KALIL, Roberto; PORTER, ThomasbookPart Anatomia e função cardíaca na prática: Ecodopplercardiografia(2017) TSUTSUI, Jeane Mike; LIMA, Márcio Silva Miguel; MATHIAS JUNIOR, WilsonconferenceObject Effect of sonothrombolysis on recanalization rates, ventricular remodeling and mechanics. Results of a single center, randomized trial in patients with first acute ST elevation myocardial infarction(2017) AGUIAR, M. O. Dias; TAVARES, B. Garcia; TSUTSUI, J. M.; LOPES, B. Baptista C.; CRUZ, C. B. B. Viana; NICOLAU, J. C.; VIANA, E. Prado; OLIVEIRA, M. T.; SOEIRO, A.; RIBEIRO, E.; LEMOS, P.; PORTER, T. R.; LIMA, F.; KALIL FILHO, R.; MATHIAS JR., W.- Global Longitudinal Strain or Left Ventricular Twist and Torsion? Which Correlates Best with Ejection Fraction?(2017) LIMA, Marcio Silva Miguel; VILLARRAGA, Hector R.; ABDUCH, Maria Cristina Donadio; LIMA, Marta Fernandes; CRUZ, Cecilia Beatriz Bittencourt Viana; SBANO, Joao Cesar Nunes; VOOS, Mariana Callil; MATHIAS JUNIOR, Wilson; TSUTSUI, Jeane MikeBackground: Estimative of left ventricular ejection fraction (LVEF) is a major indication for echocardiography. Speckle tracking echocardiography (STE) allows analysis of LV contraction mechanics which includes global longitudinal strain (GLS) and twist/torsion, both the most widely used. Direct comparison of correlations between these novel parameters and LVEF has never been done before. Objective: This study aims to check which one has the highest correlation with LVEF. Methods: Patients with normal LVEF (> 0,55) and systolic dysfunction (LVEF < 0,55) were prospectively enrolled, and underwent echocardiogram with STE analysis. Correlation of variables was performed by linear regression analysis. In addition, correlation among levels of LV systolic impairment was also tested. Results: A total of 131 patients were included (mean age, 46 +/- 14y; 43%, men). LVEF and GLS showed a strong correlation (r = 0.95; r(2) = 0.89; p < 0.001), more evident in groups with LV systolic dysfunction than those with preserved LVEF. Good correlation was also found with global longitudinal strain rate (r = 0.85; r(2) = 0.73; p < 0.001). Comparing to GLS, correlation of LVEF and torsional mechanics was weaker: twist (r = 0.78; r(2) = 0.60; p < 0.001); torsion (r = 0.75; r(2) = 0.56; p < 0.001). Conclusion: GLS of the left ventricle have highly strong positive correlation with the classical parameter of ejection fraction, especially in cases with LV systolic impairment. Longitudinal strain rate also demonstrated a good correlation. GLS increments analysis of LV systolic function. On the other hand, although being a cornerstone of LV mechanics, twist and torsion have a weaker correlation with LV ejection, comparing to GLS.