JEANE MIKE TSUTSUI
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- Influence of Physical Training after a Myocardial Infarction on Left Ventricular Contraction Mechanics(2023) LIMA, Marcio Silva Miguel; DALCOQUIO, Talia Falcao; ABDUCH, Maria Cristina Donadio; TSUTSUI, Jeane Mike; MATHIAS, Wilson; NICOLAU, Jose CarlosBackground: Exercise plays a positive role in the course of the ischemic heart disease, enhancing functional capacity and preventing ventricular remodeling.Objective: To investigate the impact of exercise on left ventricular (LV) contraction mechanics after an uncomplicated acute myocardial infarction (AMI).Methods: A total of 53 patients was included, 27 of whom were randomized to a supervised training program (TRAINING group), and 26 to a CONTROL group, who received usual recommendations on physical exercise after AMI. All patients underwent cardiopulmonary stress testing and a speckle tracking echocardiography to measure several parameters of LV contraction mechanics at one month and five months after AMI. A p value < 0.05 was considered statistically significant in the comparisons of the variables.Results: No significant difference was found in the analysis of LV longitudinal, radial and circumferential strain parameters between groups after the training period. After the training program, analysis of torsional mechanics demonstrated a reduction in the LV basal rotation in the TRAINING group in comparison to the CONTROL group (5.9 +/- 2.3 vs. 7.5 +/- 2.9o; p=0.03), and in the basal rotational velocity (53.6 +/- 18.4 vs.68.8 +/- 22.1 degrees/s; p=0.01), twist velocity (127.4 +/- 32.2 vs. 149.9 +/- 35.9 degrees/s; p=0.02) and torsion (2.4 +/- 0.4 vs. 2.8 +/- 0.8 degrees/cm; p=0.02).Conclusions: Physical activity did not cause a significant improvement in LV longitudinal, radial and circumferential deformation parameters. However, the exercise had a significant impact on the LV torsional mechanics, consisting of a reduction in basal rotation, twist velocity, torsion and torsional velocity which can be interpreted as a ventricular ""torsion reserve"" in this population.
article 0 Citação(ões) na Scopus The clinical use of stress echocardiography in non-ischaemic heart disease: recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography (vol 17, 1191, 2016)(2017) LANCELLOTTI, Patrizio; PELLIKKA, Patricia A.; DULGHERU, Raluca; EDVARDSEN, Thor; GARBI, Madalina; HA, Jong Won; KREEGER, Joe; MERTENS, Luc; PICANO, Eugenio; RYAN, Thomas; TSUTSUI, Jeane M.; VARGA, Albert; BUDTS, Werner; CHAUDHRY, Farooq A.; DONAL, Erwan; KANE, Garvan C.; PIBAROT, Philippe- The clinical use of stress echocardiography in non-ischaemic heart disease: recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography (vol 17, pg 1191, 2016)(2017) LANCELLOTTI, Patrizio; PELLIKKA, Patricia A.; DULGHERU, Raluca; EDVARDSEN, Thor; GARBI, Madalina; HA, Jong Won; KREEGER, Joe; MERTENS, Luc; PICANO, Eugenio; RYAN, Thomas; TSUTSUI, Jeane M.; VARGA, Albert
conferenceObject Sonothrombolysis Improves Cardiac Segmental Contractility, Myocardial Perfusion and Baroreflex Gain in Patients With ST-segment Elevation Myocardial Infarction (stemi) in Long-Term Follow-Up(2021) AZEVEDO, Luciene F.; BORGES, Bruno Carter C.; TOSCHI-DIAS, Edgar; FERREIRA-SANTOS, Larissa; GROEHS, Raphaela V.; TSUTSUI, Jeane M.; GUIMARAES, Amisa; OLIVEIRA, Marco C.; SMANIO, Paola E.; PORTER, Thomas R.; MATHIAS JR., Wilson- The Impact of Sonothrombolysis on Left Ventricular Diastolic Function and Left Atrial Mechanics Preventing Left Atrial Remodeling in Patients With ST Elevation Acute Myocardial Infarction(2023) CHIANG, Hsu Po; AGUIAR, Miguel O. D.; TAVARES, Bruno G.; ROSA, Vitor E. E.; GOMES, Sergio Barros; OLIVEIRA, Mucio T.; SOEIRO, Alexandre; NICOLAU, Jose C.; RIBEIRO, Henrique B.; SBANO, Joao C.; ROCHITTE, Carlos E.; FILHO, Roberto Kalil; RAMIRES, Jose A. F.; PORTER, Thomas R.; MATHIAS, Wilson; TSUTSUI, Jeane M.Background: The diagnostic ultrasound-guided high mechanical index impulses during an intravenous micro -bubble infusion (sonothrombolysis) improve myocardial perfusion in acute ST segment elevation myocardial infarction, but its effect on left ventricular diastolic dysfunction (DD), left atrial (LA) mechanics and remodeling is unknown. We assessed the effect of sonothrombolysis on DD grade and LA mechanics. Methods: One hundred patients (59 +/- 10 years; 34% women) were randomized to receive either high mechan-ical index impulses plus percutaneous coronary intervention (PCI) (therapy group) or PCI only (control group) (n = 50 in each group). Diastolic dysfunction grade and LA mechanics were assessed immediately before and after PCI and at 48 to 72 hours, 1 month, and 6 months of follow-up. Diastolic dysfunction grades were clas-sified as grades I, II, and III. The LA mechanics was obtained by two-dimensional speckle-tracking echocardiography-derived global longitudinal strain (GLS).Results: As follow-up time progressed, increased DD grade was observed more frequently in the control group than in the therapy group at 1 month and 6 months of follow-up (all P < .05). The LA-GLS values were incre-mentally higher in the therapy group when compared with the control group at 48 to 72 hours, 24.0% +/- 7.3% in the therapy group versus 19.6% +/- 7.2% in the control group, P = .005; at 1 month, 25.3% +/- 6.3% in the ther-apy group versus 21.5% +/- 8.3% in the control group, P = .020; and at 6 months, 26.2% +/- 8.7% in the therapy group versus 21.6% +/- 8.5% in the control group, P = .015. The therapy group was less likely to experience LA remodeling (odds ratio, 2.91 [1.10-7.73]; P = .03). LA-GLS was the sole predictor of LA remodeling (odds ratio, 0.79 [0.67-0.94]; P = .006).Conclusion: Sonothrombolysis is associated with better DD grade and LA mechanics, reducing LA remodel-ing. (J Am Soc Echocardiogr 2023;36:504-13.)