ANA PAULA PEREIRA VELOSA
Índice h a partir de 2011
12
Projetos de Pesquisa
Unidades Organizacionais
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
conferenceObject Type V collagen induced pulmonary fibrosis in C57B1/6mice(2014) TEODORO, Walcy Rosolia; VELOSA, Ana Paula Pereira; SANTOS FILHO, Antonio dos; ANDRADE, Priscila Cristina; MARTINS, Vanessa; FERNEZLIAN, Sandra Morais; CATANOZI, Sergio; CAPELOZZI, Vera LuisaconferenceObject Collagen V Maintains Experimental Pulmonary Fibrosis In Il17-dependent And -Independent Pathways(2013) FABRO, A. T.; SILVA, P. Q.; ZOCOLARO, W. S.; ALMEIDA, M. S.; MINATEL, I. O.; PRANDO, E. C.; RAINHO, C. A.; VELOSA, A. P.; TEODORO, W. R.; PARRA-CUENTAS, E. R.; POPPER, H. H.; CAPELOZZI, V. L.- Modeling extracellular matrix through histo-molecular gradient in NSCLC for clinical decisions(2022) BALDAVIRA, Camila Machado; PRIETO, Tabatha Gutierrez; MACHADO-RUGOLO, Juliana; MIRANDA, Jurandir Tomaz de; OLIVEIRA, Lizandre Keren Ramos de; VELOSA, Ana Paula Pereira; TEODORO, Walcy Rosolia; AB'SABER, Alexandre; TAKAGAKI, Teresa; CAPELOZZI, Vera LuizaLung cancer still represents a global health problem, being the main type of tumor responsible for cancer deaths. In this context, the tumor microenvironment, and the extracellular matrix (ECM) pose as extremely relevant. Thus, this study aimed to explore the prognostic value of epithelial-to-mesenchymal transition (EMT), Wnt signaling, and ECM proteins expression in patients with non-small-cell lung carcinoma (NSCLC) with clinical stages I-IIIA. For that, we used 120 tissue sections from patients and evaluated the immunohistochemical, immunofluorescence, and transmission electron microscopy (TEM) to each of these markers. We also used in silico analysis to validate our data. We found a strong expression of E-cadherin and beta-catenin, which reflects the differential ECM invasion process. Therefore, we also noticed a strong expression of chondroitin sulfate (CS) and collagens III and V. This suggests that, after EMT, the basal membrane (BM) enhanced the motility of invasive cells. EMT proteins were directly associated with WNT5A, and collagens III and V, which suggests that the WNT pathway drives them. On the other hand, heparan sulfate (HS) was associated with WNT3A and SPARC, while WNT1 was associated with CS. Interestingly, the association between WNT1 and Col IV suggested negative feedback of WNT1 along the BM. In our cohort, WNT3A, WNT5A, heparan sulfate and SPARC played an important role in the Cox regression model, influencing the overall survival (OS) of patients, be it directly or indirectly, with the SPARC expression stratifying the OS into two groups: 97 months for high expression; and 65 for low expression. In conclusion, the present study identified a set of proteins that may play a significant role in predicting the prognosis of NSCLC patients with clinical stages I-IIIA.
conferenceObject Collagen V overexpression correlates with IL-17+cells in C57BL/6 mice pulmonary remodeling(2014) ANDRADE, Priscila Cristina; VELOSA, Ana Paula Pereira; SANTOS FILHO, Antonio dos; MORAIS, Sandra de; EHER, Esmeralda Miristeni; CATANOZI, Sergio; CAPELOZZI, Vera Luisa; TEODORO, Walcy RosoliaconferenceObject IL-17+cells immunoexpression in systemic sclerosis pulmonary fibrosis(2014) VELOSA, Ana Paula Pereira; PAIVA, Michelle Abdo; ANDRADE, Priscila Cristina; CHRISTMANN, Romy Beatriz; EHER, Esmeralda Miristeni; FERNEZLIAN, Sandra Morais; PARRA, Edwin Roger; TEODORO, Walcy Rosolia; CAPELOZZI, Vera Luiza- Mesenchymal stem cells and conditioned medium in myofibroblast modulation and collagen production in vascular adventitia and parenchyma of experimental pulmonary fibrosis model(2016) FELIX, Renato Goncalves; BOVOLATO, Ana Livia Carvalho; LEAO, Patricia Santos; SANTOS, Amanda Luisa dos; VELOSA, Ana Paula Pereira; TEODORO, Walcy Rosolia; DEFFUNE, Elenice; FABRO, Alexandre Todorovic; CAPELOZZI, Vera Luiza