ROSANA CAMARA AGONDI
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular, Hospital das Clínicas, Faculdade de Medicina
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular, Hospital das Clínicas, Faculdade de Medicina
39 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 39
bookPart Imunobiológicos(2022) AGONDI, Rosana Câmara; GIAVINA-BIANCHI, Pedro; KALIL, Jorge- Chronic Spontaneous Urticaria: Response to Antileukotriene(2017) LOPES, Mariele Morandin; SALLES, Pamella Diogo; DANTAS, Paula; KALIL, Jorge; MOTTA, Antonio Abilio; AGONDI, Rosana Camara
conferenceObject Esophagogastroduodenal Mucosal Behavior after Bronchial Challenge with House Dust Mites in Allergic Asthmatic Patients(2015) AGONDI, Rosana C.; NAVARRO-RODRIGUEZ, Tomas; BARBUTI, Ricardo; BISACCIONI, Carla; AUN, Marcelo Vivolo; KALIL, Jorge; GIAVINA-BIANCHI, PedroconferenceObject Chronic spontaneous urticaria and autoimmunity: a follow up study of patients with chronic urticaria for 16 years(2018) MOUCO, Claudia Castilho; ZANANDREA, Andressa; ASSIS, Joao Paulo de; CASTRO, Raisa Borges; DIAS, Gabriella Melo Fontes Silva; KALIL, Jorge; MOTTA, Antonio Abilio; AGONDI, Rosana C.- AERD: PERSPECTIVE OF THE USE OF LICENSED MONOCLONALS FOR TREATMENT BASED ON THEIR PHENOTYPES(2019) DIAS, Gabriella M. F. S.; ASSIS, Joao Paulo de; CASTRO, Raisa Borges; KALIL, Jorge; GIAVINA-BIANCHI, Pedro; AGONDI, Rosana C.
- Hypersensitivity to dipyrone in aspirin-exacerbated respiratory disease patients is associated with urticaria(2020) AGONDI, Rosana Camara; DIAS, Gabriella Melo Fontes Silva; ASSIS, Joao Paulo de; PACHECO, Rosilane; KALIL, Jorge; GIAVINA-BIANCHI, PedroObjective: To phenotype patients with aspirin-exacerbated respiratory disease (AERD) according to the presence of atopy, urticaria and level of peripheral eosinophils. Methods: This study included adult asthmatic patients with AERD followed up at a tertiary hospital. They were classified according to atopy and/or urticaria, assessing clinical and laboratorial differences among the groups in order to identify possible aggravating factors of the disease. Results: We included 73 patients, 78.1% being female with a mean age of 54.0 years. Severe asthma was observed in 68.5% and respiratory exacerbation with dipyrone in 67.1% of these patients. They had median total serum IgE of 191.6 IU/mL, mean peripheral eosinophils of 718.5 cells/mm(3), and 50.7% were atopic. Urticaria was observed in 32.9% of them, and exacerbations were more often triggered by dipyrone (p = .016). Atopic patients were younger than nonatopic patients (p = .023), and had, on average, higher total serum IgE levels (p = .022). We observed a good correlation between asthma severity and peripheral eosinophils count (r(2) = 026; p = .021). Conclusions: In this study, severe asthma was highly prevalent in AERD patients. Likewise, urticaria was quite prevalent and its presence was associated with dipyrone induced hypersensitivity reaction. Atopy was found in half of the patients, with no association with asthma severity. Patients with higher levels of peripheral eosinophils had more severe asthma. Dypirone hypersensitivity may be a marker for concomitant respiratory and cutaneous hypersensitivity reactions.
- Vocal cord dysfunction diagnosis may be improved by a screening check list(2016) PINTO, Lucia Helena Eduardo; AUN, Marcelo Vivolo; CUKIER-BLAJ, Sabrina; STELMACH, Rafael; CUKIER, Alberto; KALIL, Jorge; AGONDI, Rosana Camara; GIAVINA-BIANCHI, PedroBackground: Many patients with vocal cord dysfunction (VCD), with or without asthma, receive inappropriate treatment because they are misdiagnosed as having difficult-to-control asthma alone. We developed a clinical screening check list designed to aid the diagnosis of VCD. Methods: A prospective observational study involving 80 patients aged >= 8 years, diagnosed with severe asthma. After anamnesis and physical examination, physicians completed a check list with 6 questions to identify VCD, for which the answer ""yes"" counted one point. Then patients underwent spirometry and laryngoscopy. On the basis of the laryngoscopic findings, we created three patient groups: VCD (vocal cord adduction during inspiration, n = 14); unconfirmed VCD (inconclusive findings, n = 29); and control (normal findings, n = 37). We attempted to determine whether any of those groups were associated with the responses to individual questions or sets of questions on the check list. Results: The proportion of affirmative answers to the question ""Does pulmonary auscultation reveal wheezing, predominantly in the cervical region, and/or stridor?"" was significantly higher for the VCD group than for the other two groups (P = 0.006), notably in elderly patients. The variable ""4 or more affirmative answers"" was more common in VCD and unconfirmed VCD groups in comparison to controls (P = 0.022). Conclusions: A finding of wheezing or stridor on auscultation of the cervical region is suggestive of vocal cord dysfunction, especially in elderly patients, and such dysfunction can be confirmed through laryngoscopy. Our VCD screening check list proved to be useful in the screening of VCD among patients with severe asthma.
conferenceObject Characterization of Asthmatic Patients with Vocal Cord Dysfunction(2013) AGONDI, Rosana C.; GALVAO, Violeta; AUN, Marcelo; BISACCIONI, Carla; KALIL, Jorge; GIAVINA-BIANCHI, PedroRATIONALE: The vocal cord dysfunction (VCD) is a syndrome characterized by paradoxical movement of the vocal folds that causes respiratory distress. Our goal is to analyze asthmatic patients with VCD. METHODS: This was an observational and cross-sectional study involving patients over 18 years of age who had been diagnosed with asthma according to the Global Initiative for Asthma guidelines. Eighty-five patients were analyzed. They were submitted to spirometry, and tested for total and specific IgE to aeroallergens (skin prick test and/or in vitro ). RESULTS: The mean age was 52.1 years, and 93% were female. Sixty- seven patients had moderate or severe persistent asthma. Spirometry was normal or showed mild obstructive respiratory disease in 81% of them. Spirometric alterations suggestive of VCD were observed in 24% of the patients. The mean serum total IgE was 303 IU/mL and the detection of specific IgE was present in 76% of them. Gastroesophageal reflux disease was observed in 65% of the patients. When classified according to gender, we found that men were younger, had higher total IgE and higher prevalence of specific IgE. CONCLUSIONS: There was a higher prevalence of the association asthma and VCD in women, suggesting that this association could be masked in men. However, we observed that the clinical characteristics were different between men and women. We found a high prevalence of atopy that could be another confounding factor. There was a weak association between asthma and spirometric severity classifications, suggesting a potential role for VCD in making difficult to the asthma control in some patients.- Asthma studies should be phenotype specific(2013) GIAVINA-BIANCHI, Pedro; AGONDI, Rosana Camara; KALIL, Jorge
conferenceObject Angioedema in patients with chronic spontaneous urticaria: assessment of disease severity and response to treatment(2018) ASSIS, Joao Paulo de; DIAS, Gabriella Melo Fontes Silva; MOUCO, Claudia Castilho; ZANANDREA, Andressa; CASTRO, Raisa Borges; KALIL, Jorge; MOTTA, Antonio Abilio; AGONDI, Rosana C.