ROSANA CAMARA AGONDI

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Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular, Hospital das Clínicas, Faculdade de Medicina

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Autor e Coautores FMUSP-HC Normalizados: MILTON DE ARRUDA MARTINS ×

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  • conferenceObject
    Aerobic training decreases bronchial hyperresponsiveness, serum chemokines and symptoms in asthmatic patients: Randomized controlled trial
    (2013) MENDES, Felipe; FRANCA-PINTO, Andrezza; CUKIER, Alberto; STELMACH, Rafael; AGONDI, Rosana; MARTINS, Milton A.; KALIL, Jorge; GIAVINA-BIANCHI, Pedro; CARVALHO, Celso R. F.
  • conferenceObject
    Occupational asthma and allergic asthma: differences in the physical activity level, clinical control, and airway inflammation
    (2023) SILVA, Ronaldo Aparecido Da; FREITAS, Lucas Rodrigues Silva; ALMEIDA, Francine Maria De; GALVAO, Clovis Eduardo Santos; NOGUEIRA, Soraia Felix; BEZERRA, Suellen Karoline Moreira; CARVALHO, Celso Ricardo Fernades De; ARAUJO, Kaique Alves De; CRUZ, Fabiola Matos Da; AGONDI, Rosana Camara; MARTINS, Milton Arruda; TIBERIO, Iolanda De Fatima Lopes Calvo; SARAIVA-ROMANHOLO, Beatriz Mangueira
  • conferenceObject
    Aerobic training decrease bronchial hyperresponsiveness and systemic inflammation in patients with moderate or severe asthma: A randomized controlled trial
    (2014) CARVALHO, Celso R. F.; FRANCA-PINTO, Andrezza; MENDES, Felipe A. R.; STELMACH, Rafael; CUKIER, Alberto; AGONDI, Rosana C.; MARTINS, Milton A.; SARAIVA-ROMANHOLO, Beatriz M.; KALIL, Jorge; GIAVINA-BIANCHI, Pedro
  • conferenceObject
    Exercise induced bronchoconstriction is associated with eosinophilic bronchitis in non-asthmatic elite marathon runners
    (2015) TEIXEIRA, Renata Nakata; AGONDI, Rosana Camara; MARTINS, Milton de Arruda; CARVALHO, Celso R. F.
  • article 150 Citação(ões) na Scopus
    Aerobic training decreases bronchial hyperresponsiveness and systemic inflammation in patients with moderate or severe asthma: a randomised controlled trial
    (2015) FRANCA-PINTO, Andrezza; MENDES, Felipe A. R.; CARVALHO-PINTO, Regina Maria de; AGONDI, Rosana Camara; CUKIER, Alberto; STELMACH, Rafael; SARAIVA-ROMANHOLO, Beatriz M.; KALIL, Jorge; MARTINS, Milton A.; GIAVINA-BIANCHI, Pedro; CARVALHO, Celso R. F.
    Background The benefits of aerobic training for the main features of asthma, such as bronchial hyperresponsiveness (BHR) and inflammation, are poorly understood. We investigated the effects of aerobic training on BHR (primary outcome), serum inflammatory cytokines (secondary outcome), clinical control and asthma quality of life (Asthma Quality of Life Questionnaire (AQLQ)) (tertiary outcomes). Methods Fifty-eight patients were randomly assigned to either the control group (CG) or the aerobic training group (TG). Patients in the CG (educational programme+breathing exercises (sham)) and the TG (same as the CG+aerobic training) were followed for 3 months. BHR, serum cytokine, clinical control, AQLQ, induced sputum and fractional exhaled nitric oxide (FeNO) were evaluated before and after the intervention. Results After 12 weeks, 43 patients (21 CG/22 TG) completed the study and were analysed. The TG improved in BHR by 1 doubling dose (dd) (95% CI 0.3 to 1.7 dd), and they experienced reduced interleukin 6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1) and improved AQLQ and asthma exacerbation (p<0.05). No effects were seen for IL-5, IL-8, IL-10, sputum cellularity, FeNO or Asthma Control Questionnaire 7 (ACQ-7; p>0.05). A within-group difference was found in the ACQ-6 for patients with non-well-controlled asthma and in sputum eosinophil and FeNO in patients in the TG who had worse airway inflammation. Conclusions Aerobic training reduced BHR and serum proinflammatory cytokines and improved quality of life and asthma exacerbation in patients with moderate or severe asthma. These results suggest that adding exercise as an adjunct therapy to pharmacological treatment could improve the main features of asthma.
  • article 3 Citação(ões) na Scopus
    Clinical, functional and inflammatory evaluation in asthmatic patients after a simple short-term educational program: a randomized trial
    (2021) FELIX, Soraia Nogueira; AGONDI, Rosana Camara; AUN, Marcelo Vivolo; OLIVO, Clarice Rosa; ALMEIDA, Francine Maria de; AMORIM, Thais Santos; CEZARIO, Julia Caroline; GIAVINA-BIANCHI, Pedro; TIBERIO, Iolanda de Fatima Lopes Calvo; MARTINS, Milton de Arruda de; ROMANHOLO, Beatriz Mangueira Saraiva
    This study aimed to evaluate the clinical evolution, functional parameters and inflammatory activity of asthma in patients who submitted to an educational intervention. 58 adult patients over 18 years of age with partly controlled and uncontrolled asthma were randomized into an intervention group (IG) (N = 32) and a control group (CG) (N = 26) and evaluated for 12 weeks. The Asthma Control Test (ACT), Asthma Control Questionnaire (ACQ), Asthma Quality Life Questionnaire (AQLQ) and Beck Depression Inventory (BDI) questionnaires were applied. Spirometry, exhaled nitric oxide (NO), exhaled breath condensate (EBC) and induced sputum (IS), measurement of the peak flow and symptoms were performed. The IG patients received an educational activity for 30 min applied by a nurse. Statistical analysis: analysis of variance with repeated intragroup measures. IG presented a decreased number of eosinophils in IS and IL-17A in EBC, an increase in the percentage of FEV1 before and after bronchodilator and an improvement in quality of life compared to the CG. There was an improvement in depression levels and a decrease in IL-4 and IL-5 in the IS and in the EBC in both groups. Our results suggest that an educational intervention can bring benefits concerning the control of inflammation, lung function alterations, quality of life and levels of depression in asthmatic patients. Registration: ClinicalTrials.gov; NCT03655392.
  • bookPart 0 Citação(ões) na Scopus
    Occupational allergy in elite runners
    (2014) TEIXEIRA, R. N.; ROMANHOLO, B. S.; AGONDI, R. C.; PINTO, A. F.; MARTINS, M. de Arruda; CARVALHO, C. R. F.
    Background: The prevalence of allergy, asthma and airwayinflammation and hyperresponsiveness in elite athletes has increased overthe years and appears to vary between sport modalities. Although allergicand respiratory diseases have been extensively studied in enduranceathletes, especially swimmers and winter sports athletes, the prevalencein elite runners remains unknown.Objective: The aims of this study were to screen allergy symptoms inelite runners and to evaluate the airway responsiveness and airwayinflammatory cells in these athletes.Methods: One hundred and thirty elite runners were invited tocomplete the Allergy Questionnaire for Athletes (AQUA©), a validatedquestionnaire to screen allergy in athletes, in addition to answeringquestions related to training history, running distance per week and bestrace time in a marathon or half-marathon. A subgroup of 36 nonasthmaticathletes also performed the methacholine challenge test,sputum induction and cardiopulmonary exercise testing. Airwayinflammation was quantified via cellular airway infiltration.Results: The presence of allergy was based on the AQUA© totalscore, and athletes were classified as either AQUA+ or AQUA- (a score=5 or <5, respectively). Sixty-one athletes (60%) reported allergysymptoms, and no significant differences between the groups (AQUA+and AQUA-) were observed regarding gender, age, running experience,weekly training volume or best performance time in a half-marathon ormarathon (p>0.05). Most athletes presented airway inflammation witheosinophilic predominance (23.6%); however, only 8.3% of the eliterunners had a positive response to methacoline challenge.Conclusions: Our study demonstrated that elite runners have a highprevalence of allergy and eosinophilic airway inflammation withoutevidence of airway hyperresponsiveness; this finding was independent ofgender, age, quantity of training and performance. © 2014 Nova Science Publishers, Inc. All rights reserved.
  • conferenceObject
    Exercise-induced bronchoconstriction and airway inflammation in elite long distance runners
    (2014) TEIXEIRA, Renata Nakata; ROMANHOLO, Beatriz Saraiva; AGONDI, Rosana Camara; MARTINS, Milton De Arruda; CARVALHO, Celso R. F.
  • conferenceObject
    Effect of aerobic exercise training on bronchial hyperresponsiveness, airway inflammation and health related quality of life in asthmatic patients: A pilot study
    (2012) PINTO, Andrezza; MENDES, Felipe; AGONDI, Rosana; SARAIVA-ROMANHOLO, Beatriz; STELMACH, Rafael; CUKIER, Alberto; MARTINS, Milton; KALIL, Jorge; CARVALHO, Celso; GIAVINA-BIANCHI, Pedro
  • conferenceObject
    Clinical, Functional and Inflammatory Evaluation in Asthmatic Patients After a Simple Short-Term Educational Program
    (2018) FELIX, S. N.; AGONDI, R. C.; AUN, M. V.; KURKEJAK, A.; AVONA, M. D.; AMORIM, T. S.; LOPES, M. R.; ALMEIDA, F. M.; GENARO, I. S.; BEZERRA, S. K.; GIAVINA-BIANCHI, P.; KALIL, J.; TIBERIO, I. D.; MARTINS, M. D.; SARAIVA-ROMANHOLO, B. M.