ROSANA CAMARA AGONDI
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular, Hospital das Clínicas, Faculdade de Medicina
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular, Hospital das Clínicas, Faculdade de Medicina
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
conferenceObject Characterization of Asthmatic Patients with Vocal Cord Dysfunction(2013) AGONDI, Rosana C.; GALVAO, Violeta; AUN, Marcelo; BISACCIONI, Carla; KALIL, Jorge; GIAVINA-BIANCHI, PedroRATIONALE: The vocal cord dysfunction (VCD) is a syndrome characterized by paradoxical movement of the vocal folds that causes respiratory distress. Our goal is to analyze asthmatic patients with VCD. METHODS: This was an observational and cross-sectional study involving patients over 18 years of age who had been diagnosed with asthma according to the Global Initiative for Asthma guidelines. Eighty-five patients were analyzed. They were submitted to spirometry, and tested for total and specific IgE to aeroallergens (skin prick test and/or in vitro ). RESULTS: The mean age was 52.1 years, and 93% were female. Sixty- seven patients had moderate or severe persistent asthma. Spirometry was normal or showed mild obstructive respiratory disease in 81% of them. Spirometric alterations suggestive of VCD were observed in 24% of the patients. The mean serum total IgE was 303 IU/mL and the detection of specific IgE was present in 76% of them. Gastroesophageal reflux disease was observed in 65% of the patients. When classified according to gender, we found that men were younger, had higher total IgE and higher prevalence of specific IgE. CONCLUSIONS: There was a higher prevalence of the association asthma and VCD in women, suggesting that this association could be masked in men. However, we observed that the clinical characteristics were different between men and women. We found a high prevalence of atopy that could be another confounding factor. There was a weak association between asthma and spirometric severity classifications, suggesting a potential role for VCD in making difficult to the asthma control in some patients.- Asthma studies should be phenotype specific(2013) GIAVINA-BIANCHI, Pedro; AGONDI, Rosana Camara; KALIL, Jorge
- Can patients with common variable immunodeficiency have allergic rhinitis?(2013) AGONDI, Rosana C.; BARROS, Myrthes T.; KOKRON, Cristina M.; COHON, Andrea; OLIVEIRA, Ana K. B.; KALIL, Jorge; GIAVINA-BIANCHI, PedroBackground: Rhinosinusitis is highly prevalent in patients with common variable immunodeficiency (CVID), and probably allergic rhinitis (AR) may be masked by a history of repeated respiratory infections. The diagnosis of AR is based on the patient's symptoms and detection of specific immunoglobulin E (IgE) to aeroallergens. This study was designed to identify rhinitis of probable allergic cause in patients with CVID. Methods: This study included 72 adult CVID patients. The patients were divided into three groups according to their history: suggestive of AR, nonallergic rhinitis, and without rhinitis. They were tested for total and specific IgE (in vivo and in vitro). Results: The patients' mean age was 38.2 years. A history of chronic rhinitis was observed in 59 (81.9%) of the cases, 31 of which (43%) had a history suggestive of AR. Patients with a history of rhinitis (whether allergic or nonallergic) presented an earlier onset of symptoms and diagnosis of CVID. Total IgE was undetectable in 86.1% of patients. AR was confirmed by detection of specific IgE to aeroallergens in only 5.6% of the patients. Conclusion: In CVID patients, chronic rhinitis may be allergic, because many have personal and family histories suggestive of atopy. However, in this study, allergy was confirmed by specific IgE detection in only 5.6% of cases. CVID patients with a history suggestive of AR commonly present negative results on traditional testing, so additional experiments may be necessary. One suggestion for the investigation of AR in CVID patients would be nasal provocation with the most prevalent allergens.
conferenceObject Aerobic training decreases bronchial hyperresponsiveness, serum chemokines and symptoms in asthmatic patients: Randomized controlled trial(2013) MENDES, Felipe; FRANCA-PINTO, Andrezza; CUKIER, Alberto; STELMACH, Rafael; AGONDI, Rosana; MARTINS, Milton A.; KALIL, Jorge; GIAVINA-BIANCHI, Pedro; CARVALHO, Celso R. F.- Rhinoconjunctivitis elicited by skin prick test (vol 38, pg 345, 2010)(2013) GIAVINA-BIANCHI, P.; BISACCIONI, C.; AUN, M. Vivolo; CAJUELA, E.; AGONDI, R. C.; KALIL, J.