GUILHERME VANONI POLANCZYK
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Psiquiatria, Faculdade de Medicina - Docente
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina - Líder
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- Do Phenotypic Characteristics, Parental Psychopathology, Family Functioning, and Environmental Stressors Have a Role in the Response to Methylphenidate in Children With Attention-Deficit/Hyperactivity Disorder? A Naturalistic Study From a Developing Country(2011) CHAZAN, Rodrigo; BOROWSKI, Carolina; PIANCA, Thiago; LUDWIG, Henrique; ROHDE, Luis Augusto; POLANCZYK, GuilhermeLittle is known about the effect of clinical characteristics, parental psychopathology, family functioning, and environmental stressors in the response to methylphenidate in children with attention-deficit/hyperactivity disorder (ADHD) followed up in a naturalistic setting. Data from cultures outside the United States are extremely scarce. This is a longitudinal study using a nonrandom assignment, quasi-experimental design. One hundred twenty-five children with ADHD were treated with methylphenidate according to standard clinical procedures, and followed up for 6 months. The severity of ADHD symptoms was assessed by the Swanson, Nolan, and Pelham rating scale. In the final multivariate model, ADHD combined subtype (P < 0.001) and comorbidity with oppositional defiant disorder (P = 0.03) were both predictors of a worse clinical response. In addition, the levels of maternal ADHD symptoms were also associated with worse prognosis (P < 0.001). In the context of several adverse psychosocial factors assessed, only undesired pregnancy was associated with poorer response to methylphenidate in the final comprehensive-model (P = 0.02). Our study provides evidence for the involvement of clinical characteristics, maternal psychopathology, and environmental stressors in the response to methylphenidate. Clinicians may consider adjuvant strategies when negative predictors are present to increase the chances of success with methylphenidate treatment.
- Monozygotic Twins Discordant for Being Bullied: A Step Closer to Understanding the Biology of Victimization(2011) POLANCZYK, Guilherme V.
article Can countertransference at the early stage of trauma care predict patient dropout of psychiatric treatment?(2011) SILVEIRA JUNIOR, Erico de Moura; POLANCZYK, Guilherme Vanoni; HAUCK, Simone; EIZIRIK, Claudio Laks; CEITLIN, Lucia Helena FreitasObjectives: To investigate the association between feelings of countertransference (CT) at the early psychiatric care provided to trauma victims and treatment outcome. Method: The Assessment of Countertransference Scale was used to access CT after the first medical appointment. Fifty psychiatric residents cared for 131 trauma victims of whom 83% were women, aged 15 to 64 years. Patients had been consecutively selected over 4 years. Were evaluated the clinical and demographic characteristics of patients and the correlation with the therapists' CT feelings. Patients were followed-up during treatment to verify the association between initial CT and treatment outcome, defined as discharge and dropout. Results: The median number of appointments was 5 [4; 8], absences 1 [0; 1], and the dropout rate was 34.4%. Both groups, namely the discharge group and the dropout group, shared similar clinical and demographic characteristics. A multivariate analysis identified that patients with a reported history of childhood trauma were 61% less likely to dropout from treatment than patients with no reported history of childhood trauma (OR = 0.39, p = 0.039, CI95% 0.16-0.95). There was no association between initial CT and treatment outcome. Conclusions: In this sample, CT in the initial care of trauma victims was not associated with treatment outcome. Further studies should assess changes in CT during treatment, and how such changes impact treatment outcome.- Childhood Trauma and Children's Emerging Psychotic Symptoms: A Genetically Sensitive Longitudinal Cohort Study(2011) ARSENEAULT, Louise; CANNON, Mary; FISHER, Helen L.; POLANCZYK, Guilherme; MOFFITT, Terrie E.; CASPI, AvshalomObjective: Using longitudinal and prospective measures of trauma during childhood, the authors assessed the risk of developing psychotic symptoms associated with maltreatment, bullying, and accidents in a nationally representative U. K. cohort of young twins. Method: Data were from the Environmental Risk Longitudinal Twin Study, which follows 2,232 twin children and their families. Mothers were interviewed during home visits when children were ages 5, 7, 10, and 12 on whether the children had experienced maltreatment by an adult, bullying by peers, or involvement in an accident. At age 12, children were asked about bullying experiences and psychotic symptoms. Children's reports of psychotic symptoms were verified by clinicians. Results: Children who experienced maltreatment by an adult (relative risk=3.16, 95% CI=1.92-5.19) or bullying by peers (relative risk=2.47, 95% CI=1.74-3.52) were more likely to report psychotic symptoms at age 12 than were children who did not experience such traumatic events. The higher risk for psychotic symptoms was observed whether these events occurred early in life or later in childhood. The risk associated with childhood trauma remained significant in analyses controlling for children's gender, socioeconomic deprivation, and IQ; for children's early symptoms of internalizing or externalizing problems; and for children's genetic liability to developing psychosis. In contrast, the risk associated with accidents was small (relative risk=1.47, 95% CI=1.02-2.13) and inconsistent across ages. Conclusions: Trauma characterized by intention to harm is associated with children's reports of psychotic symptoms. Clinicians working with children who report early symptoms of psychosis should inquire about traumatic events such as maltreatment and bullying.
article 3 Citação(ões) na Scopus RBP increases its impact factor again and is progressively more cited in other journals(2011) CRIPPA, Jose Alexandre S.; BRESSAN, Rodrigo A.; SALUM, Giovanni Abrahao; QUEVEDO, Joao; KIELING, Christian; HOEXTER, Marcelo Queiroz; MORIYAMA, Tais; CHAGAS, Marcos Hortes N.; FONTENELLE, Leonardo; POLANCZYK, Guilherme Vanoni; FLECK, Marcelo Pio de Almeida- Preventing mental disorders: the challenge ahead(2011) POLANCZYK, Guilherme V.
article 3 Citação(ões) na Scopus One more step to increase the internationalization and visibility of the RBP Psychiatry(2011) CRIPPA, Jose Alexandre S.; BRESSAN, Rodrigo A.; SALUM, Giovanni Abrahao; QUEVEDO, Joao; KIELING, Christian; HOEXTER, Marcelo Queiroz; MORIYAMA, Tais; CHAGAS, Marcos Hortes N.; FONTENELLE, Leonardo; POLANCZYK, Guilherme Vanoni; FLECK, Marcelo Pio de Almeidaarticle 0 Citação(ões) na Scopus New editors and new challenges(2011) FLECK, Marcelo Pio de Almeida; CRIPPA, Jose Alexandre S.; SALUM, Giovanni Abrahao; KIELING, Christian; HOEXTER, Marcelo Queiroz; MORIYAMA, Tais; FONTENELLE, Leonardo; POLANCZYK, Guilherme Vanoni; BRESSAN, Rodrigo Affonseca