MARIA CLAUDIA COSTA IRIGOYEN

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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/59 - Laboratório de Biologia Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/65, Hospital das Clínicas, Faculdade de Medicina

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Autor: IRIGOYEN, Maria Claudia ×

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Agora exibindo 1 - 10 de 133
  • conferenceObject
    Improvement of the Adipokines Profile and Insulin Resistance in Metabolic Syndrome Patients Induced by Galantamine Activation of Cholinergic Pathway
    (2016) SANGALETI, Carine Teles; COSTA, Fernando Oliveira; MORAES, Tercio Lemos; IRIGOYEN, Maria Claudia; BORTOLOTTO, Luiz Aparecido Teles; LOPES, Heno Ferreira; PAVLOV, Valentin; TRACEY, Kevin; CONSOLIM-COLOMBO, Fernanda Marciano
  • conferenceObject
    COMBINED EXERCISE TRAINING ATENUATES THE ONSET OF CARDIOMETABOLIC AND AUTONOMIC DYSFUNCTIONS IN AN EXPERIMENTAL MODEL OF METABOLIC SYNDROME
    (2017) DIAS, Danielle da Silva; BERNARDES, Nathalia; CONTI, Filipe Fernandes; BRITO, Janaina de Oliveira; SANTOS, Fernando; ARAUJO, Amanda Aparecida; OLIVEIRA, Danielle Martins; FRISENE, Natalia; IRIGOYEN, Maria Claudia; ANGELIS, Katia De
  • article 1 Citação(ões) na Scopus
    Effects of Hydroxychloroquine on endOthelial function in eLDerly with sleep apnea (HOLD): study protocol for a randomized clinical trial
    (2021) SILVA, Leticia Maria Tedesco; CORTES, Antonio; ROSSI, Beatriz; BOLL, Liliana; WACLAWOSKY, Gustavo; EIBEL, Bruna; GONCALVES, Sandro Cadaval; IRIGOYEN, Maria Claudia; MARTINEZ, Denis
    Background: Sleep apnea and coronary artery disease are prevalent and relevant diseases. The mechanism by which sleep apnea leads to coronary artery disease remains unclear. Intermittent hypoxia, caused by sleep apnea, leads to inflammation and consequent endothelial dysfunction. Endothelial dysfunction precedes the development of atherosclerotic disease and the occurrence of cardiovascular events. Agents that potentially act to improve endothelial function can help prevent cardiovascular events. Patients using immunomodulators due to rheumatic diseases have a lower prevalence of cardiovascular diseases. However, the potential cardioprotective effect of these drugs in patients without autoimmune diseases is not clear. Hydroxychloroquine (HCQ) is an immunomodulator used to treat rheumatoid arthritis and systemic lupus erythematosus. In addition to its anti-inflammatory properties, HCQ reduces cholesterol and blood glucose levels and has antithrombotic effects. The drug is inexpensive and widely available. Adverse effects of HCQ are rare and occur more frequently with high doses. Objective: In this randomized clinical trial, the effect of HCQ treatment on endothelial function will be tested in seniors with sleep apnea. Methods: We will recruit participants over the age of 65 and with moderate-severe sleep apnea from an ongoing cohort. We chose to use this sample already evaluated for sleep apnea for reasons of convenience, but also because the elderly with sleep apnea are vulnerable to heart disease. Endothelial function will be assessed by examining flow-mediated dilation of the brachial artery, the gold standard method, considered an independent predictor of cardiovascular events in the general population and by peripheral arterial tonometry, the most recent and most easily obtained method. Hydroxychloroquine will be used at a dose of 400 mg/daily for 8 weeks. Discussion: Our study aims to obtain evidence, albeit preliminary, of the efficacy of hydroxychloroquine in improving endothelial function and reducing cardiovascular risk markers. If the improvement occurs, we plan to design a randomized multicenter clinical trial to confirm the findings.
  • article 4 Citação(ões) na Scopus
    Impact of Overweight in Mens with Family History of Hypertension: Early Heart Rate Variability and Oxidative Stress Disarrangements
    (2020) VIANA, Ariane; DIAS, Danielle da Silva; NASCIMENTO, Mario Cesar; SANTOS, Fernando dos; LANZA, Fernanda de Cordoba; IRIGOYEN, Maria Claudia; ANGELIS, Katia De
    Aim. To evaluate cardiovascular, autonomic, and oxidative stress markers in eutrophic and overweight offspring of hypertensive parents comparing them to eutrophic and overweight offspring of normotensive parents.Methods. We conducted a cross-sectional study. We selected 71 male and sedentary subjects, divided into 4 groups: eutrophic group with a negative family history of hypertension (EH-,n=18) or positive family history of hypertension (EH+,n=17), overweight group with a negative family history of hypertension (OH-,n=19) or a positive family history of hypertension (OH+,n=17), and aged between 18 and 35 years.Results. Blood glucose was higher in the OH+ group when compared to other groups. Diastolic blood pressure was increased in OH- and OH+ groups when compared to eutrophic groups. Regarding the HRV, the LF abs was higher in OH- and OH+ groups when compared to the EH- group. LF/HF values were higher in EH+ and OH+ groups when compared to the EH- and OH- groups. As to oxidative stress and the metabolism of nitric oxide, we observed an increase in hydrogen peroxide and nitrite levels in the OH+ group, and in the NADPH oxidase in OH- and OH+ groups when compared to the other groups.Conclusion. Our findings demonstrate that the overweight group with a family history of hypertension presented all the dysfunctions observed in isolation from these risk factors. We observed an exacerbation of cardiac sympathetic modulation and early prooxidants increase, which may be associated with target organ damage and cardiovascular risk in this population.
  • conferenceObject
    Effects of physical exercise and high fructose diet on cardiac autonomic control in rats
    (2012) FARAH, Daniela; NUNES, Jonas Pereira; BECHARA, Ana Carolina Carneiro; YOKOTA, Rodrigo; SARTORI, Michelle; IRIGOYEN, Maria Claudia; ANGELIS, Katia De; FIORINO, Patricia; FARAH, Vera
  • conferenceObject
    DIURETIC ASSOCIATED WITH CONCURRENT EXERCISE PROMOTES ADDITIONAL PHYSICAL, AUTONOMIC AND INFLAMMATORY ADAPTATIONS IN HYPERTENSIVE RATS SUBMITTED TO OVARIAN HORMONE PRIVATION
    (2022) FERREIRA, Maycon Junior; SILVA, Gabriel Do Carmo; BERNARDES, Nathalia; ARAUJO, Amanda Aparecida De; DIAS, Danielle Da Silva; IRIGOYEN, Maria Claudia; ANGELIS, Katia De
  • article 6 Citação(ões) na Scopus
    Using a 3D printer in cardiac valve surgery: a systematic review
    (2019) BOLL, Liliana Fortini Cavalheiro; RODRIGUES, Guilherme Oberto; RODRIGUES, Clarissa Garcia; BERTOLLO, Felipe Luiz; IRIGOYEN, Maria Claudia; GOLDMEIER, Silvia
    BACKGROUND: The use of the 3D printer in complex cardiac surgery planning. OBJECTIVES: To analyze the use and benefits of 3D printing in heart valve surgery through a systematic review of the literature. METHODS: This systematic review was reported following the Preferred Reporting Items for Systematic Review and registered in the Prospero (International Prospective Register of Systematic Reviews) database under the number CRD42017059034. We used the following databases: PubMed, EMBASE, Scopus, Web of Science and Lilacs. We included articles about the keywords ""Heart Valves"", ""Heart Valve Prosthesis Implantation"", ""Heart Valve Prosthesis"", ""Printing, Three-Dimensional"", and related entry terms. Two reviewers independently conducted data extraction and a third reviewer solved disagreements. All tables used for data extraction are available at a separate website. We used the Cochrane Collaboration tool to assess the risk of bias of the studies included. RESULTS: We identified 301 articles and 13 case reports and case series that met the inclusion criteria. Our studies included 34 patients aged from 3 months to 94 years. CONCLUSIONS: Up to the present time, there are no studies including a considerable number of patients. A 3D-printed model produced based on the patient enables the surgeon to plan the surgical procedure and choose the best material, size, format, and thickness to be used. This planning leads to reduced surgery time, exposure, and consequently, lower risk of infection.
  • article 7 Citação(ões) na Scopus
    Autonomic changes in young smokers: acute effects of inspiratory exercise
    (2013) RODRIGUES, Fernando; ARAUJO, Amanda Aparecida; MOSTARDA, Cristiano Teixeira; FERREIRA, Janaina; SILVA, Michelle Cristina de Barros; NASCIMENTO, Ademir Manoel; LIRA, Fabio Santos; ANGELIS, Katia De; IRIGOYEN, Maria Claudia; RODRIGUES, Bruno
    One of the most important consequences of smoking is the development of cardiovascular diseases. However, little is known about the early consequences of smoking and the acute effects of a single inspiratory muscle exercise session (IME). We evaluated the acute effects of an IME on cardiac parameters of young smokers. Twelve nonsmokers (C) and fifteen smokers [S; 2.08 (1.0-3.2) pack-years] underwent an acute IME. We evaluated blood pressure (BP) and lactate, and we recorded RR interval for posterior analysis of heart rate variability (HRV), before and after IME. At baseline, systolic BP and HRV parameters in time and frequency domains were changed in S group in comparison with the C. Following IME, S group reduced systolic BP (-8 %), low frequency band (LF) (-21.4 %), LF/high frequency (HF) (-57 %), as well as increased RR variance (+105 %) and HF band. Our findings indicate that a single session of inspiratory muscle exercise was able to both reduce systolic BP and improve parasympathetic and sympathetic modulations in young smokers. The results of the current study highlight the importance of furthering research on this area to better elucidate the acute and chronic effects of inspiratory muscle training on early cardiovascular and pulmonary changes of cigarette smoking.
  • conferenceObject
    Combined exercise training improves cardiovascular and inflammatory parameters in an experimental model of metabolic syndrome and menopause
    (2014) CONTI, Filipe; BRITO, Janaina; DIAS, Danielle; BERNARDES, Nathalia; SANCHES, Iris; MALFITANO, Christiane; IRIGOYEN, Maria Claudia; ANGELIS, Katia De
  • article 4 Citação(ões) na Scopus
    Increase in Vascular Injury of Sodium Overloaded Mice May be Related to Vascular Angiotensin Modulation
    (2015) LIMA, Cintia Taniguti; SILVA, Juliane Cristina de Souza; VIEGAS, Katia Aparecida da Silva; OLIVEIRA, Thais Cristina de Souza; LIMA, Rariane Silva de; SOUZA, Leandro Ezequiel de; ARAGAO, Danielle; CASARINI, Dulce Elena; IRIGOYEN, Maria Claudia; LACCHINI, Silvia
    This study aimed to analyzing the effect of chronic sodium overload upon carotid and femoral injury, and its relation to vascular angiotensin modulation. Male C57Bl6 mice were divided in: control (cont), receiving 1% NaCl solution for 2 weeks (salt-2) or 12 weeks (salt-12). Two-weeks before the end of the study, a 2mm catheter was implanted around the left femoral and carotid arteries to induce injury. Blood pressure (BP) and heart rate (HR) were measured at the end of the study by tail plethysmography. Arteries were collected and prepared for histological analysis to determine arterial thickening and perivascular collagen deposition. Angiotensin II and Ang(1-7) were quantified in fresh arteries using the HPLC method. There were no differences in body weight, BP and HR. Intima/media ratio had a similar increase in both injured arteries of cont and salt-2 mice, but a more pronounced increase was observed in salt-12 mice (31.1 +/- 6%). On the other hand, sodium overload modified perivascular collagen deposition, increasing thick fibers (cont: 0.5%; salt-2: 3.4%; salt-12: 0.6%) and decreasing thin fibers (cont: 7.4%; salt-2: 0.5%; salt-12: 6.8%) in non-injured arteries. Injured arteries presented similar collagen fiber distribution. Angiotensin quantification showed increased Ang(1-7) in salt treated mice (salt-2: +72%; salt-12: +45%) with a concomitant decrease in Ang II (salt-2: -54%; salt-12: -60%). Vascular injury increased significantly Ang(1-7) in salt-12 mice (+80%), maintaining Ang II reduction similar to that of a non-injured artery. The lack of changes in BP and HR suggests that the structural changes observed may be due to non-hemodynamic mechanisms such as local renin-angiotensin system. Collagen evaluation suggests that sodium overload induces time-related changes in vascular remodeling. The increase of artery injury with concomitant increase in Ang(1-7) in 12-week treated mice shows a direct association between the duration of salt treatment and the magnitude of vascular injury.