MARIA CLAUDIA COSTA IRIGOYEN
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/59 - Laboratório de Biologia Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/65, Hospital das Clínicas, Faculdade de Medicina
LIM/59 - Laboratório de Biologia Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/65, Hospital das Clínicas, Faculdade de Medicina
17 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 17
conferenceObject Combined exercise training improves cardiovascular and inflammatory parameters in an experimental model of metabolic syndrome and menopause(2014) CONTI, Filipe; BRITO, Janaina; DIAS, Danielle; BERNARDES, Nathalia; SANCHES, Iris; MALFITANO, Christiane; IRIGOYEN, Maria Claudia; ANGELIS, Katia De- Vitamin C Protects Against Doxorubicin-Induced Muscle Oxidative Stress(2022) NASCIMENTO FILHO, Antonio Viana Do; STOYELL-CONTI, Filipe F.; AKOLKAR, Gauri; MIRANDA, Victor Hugo M. De; SINGAL, Pawan; IRIGOYEN, Maria Claudia; ANGELIS, Katia De; DIAS, Danielle Da Silva
conferenceObject Insulin Replacement Attenuates Autonomic Impairment but Did Not Prevent Early Diastolic Dysfunction in a Model of Type 1 Diabetes(2015) FREITAS, Sarah C.; DOURADO, Paulo M.; SANCHES, Iris C.; MACHI, Jacqueline F.; IRIGOYEN, Maria C.; ANGELIS, Katia DeconferenceObject Increased cardiac vagal modulation and sleep quality after 12 weeks of yoga video classes in association to respiratory control in hypertensive post menopause women(2020) FETTER, Claudia; DESOUZA, Liliane Appratto; MARQUES, Juliana Romeu; DARTORA, Daniela Ravizzoni; BOLL, Liliana Fortini Cavalheiro; COSTA, Danielle Irigoyen da; DETOGNI, Ariele; DEANGELIS, Katia; IRIGOYEN, Maria Claudia- Cardiac and pulmonary arterial remodeling after sinoaortic denervation in normotensive rats(2012) FLUES, K.; MORAES-SILVA, I. C.; MOSTARDA, C.; SOUZA, P. R. M.; DINIZ, G. P.; MOREIRA, E. D.; PIRATELLO, A. C.; CHAVES, M. L. Barreto; ANGELIS, K. De; SALEMI, Vera Maria Cury; IRIGOYEN, M. C.; CALDINI, E. G.Blood pressure variability (BPV) and baroreflex dysfunction may contribute to end-organ damage process. We investigated the effects of baroreceptor deficit (10 weeks after sinoaortic denervation - SAD) on hemodynamic alterations, cardiac and pulmonary remodeling. Cardiac function and morphology of male Wistar intact rats (C) and SAD rats (SAD) (n = 8/group) were assessed by echocardiography and collagen quantification. BP was directly recorded. Ventricular hypertrophy was quantified by the ratio of left ventricular weight (LVW) and right ventricular weight (RVW) to body weight (BW). BPV was quantified in the time and frequency domains. The atrial natriuretic peptide (ANP), alpha-skeletal actin (alpha-skelectal), collagen type I and type III genes mRNA expression were evaluated by RT-PCR. SAD did not change BP, but increased BPV (11 +/- 0.49 vs. 5 +/- 0.3 mm Hg). As expected, baroreflex was reduced in SAD. Pulmonary artery acceleration time was reduced in SAD. In addition, SAD impaired diastolic function in both LV (6.8 +/- 0.26 vs. 5.02 +/- 0.21 mm Hg) and RV (5.1 +/- 0.21 vs. 4.2 +/- 0.12 mm Hg). SAD increased LVW/BW in 9% and RVW/BW in 20%, and augmented total collagen (3.8-fold in LV, 2.7-fold in RV, and 3.35-fold in pulmonary artery). Also, SAD increased type I (similar to 6-fold) and III (similar to 5-fold) collagen gene expression. Denervation increased ANP expression in LV (75%), in RV (74%) and increased a-skelectal expression in LV (300%) and in RV (546%). Baroreflex function impairment by SAD, despite not changing BP, induced important adjustments in cardiac structure and pulmonary hypertension. These changes may indicate that isolated baroreflex dysfunction can modulate target tissue damage.
- Baroreceptor Deafferentation Impairs the Exercise Training-and Drug Treatment-Induced Adaptations in a Hypertensive Model of Menopause(2022) FERREIRA, Maycon J.; SILVA, Gabriel Do Carmo; BERNARDES, Nathalia; ARAUJO, Amanda A. De; DIAS, Danielle Da Silva; IRIGOYEN, Maria C.; ANGELIS, Katia De
- Molecular mapping of the regenerative niche in a murine model of myocardial infarction(2012) ALVES, Gabriela Dornelles; PAZZINE, Mariana; BRAGA, Luisa Maria Gomes De Macedo; IRIGOYEN, Maria Claudia; ANGELIS, Katia De; IKUTA, Nilo; CAMASSOLA, Melissa; NARDI, Nance BeyerAdult stem cells are distributed through the whole organism, and present a great potential for the therapy of different types of disease. For the design of efficient therapeutic strategies, it is important to have a more detailed understanding of their basic biological characteristics, as well as of the signals produced by damaged tissues and to which they respond. Myocardial infarction (MI), a disease caused by a lack of blood flow supply in the heart, represents the most common cause of morbidity and mortality in the Western world. Stem cell therapy arises as a promising alternative to conventional treatments, which are often ineffective in preventing loss of cardiomyocytes and fibrosis. Cell therapy protocols must take into account the molecular events that occur in the regenerative niche of MI. In the present study, we investigated the expression profile of ten genes coding for chemokines or cytokines in a murine model of MI, aiming at the characterization of the regenerative niche. MI was induced in adult C57BL/6 mice and heart samples were collected after 24 h and 30 days, as well as from control animals, for quantitative RT-PCR. Expression of the chemokine genes CCL2, CCL3, CCL4, CCL7, CXCL2 and CXCL10 was significantly increased 24 h after infarction, returning to baseline levels on day 30. Expression of the CCL8 gene significantly increased only on day 30, whereas gene expression of CXCL12 and CX3CL1 were not significantly increased in either ischemic period. Finally, expression of the IL-6 gene increased 24 h after infarction and was maintained at a significantly higher level than control samples 30 days later. These results contribute to the better knowledge of the regenerative niche in MI, allowing a more efficient selection or genetic manipulation of cells in therapeutic protocols.
- Low-dose Enalapril Reduces Angiotensin II and Attenuates Diabetic-induced Cardiac and Autonomic Dysfunctions(2012) MALFITANO, Christiane; ANGELIS, Katia De; FERNANDES, Tiago; WICHI, Rogerio Brandao; ROSA, Kaleizu; PAZZINE, Mariana; MOSTARDA, Cristiano; RONCHI, Fernanda Aparecida; OLIVEIRA, Edilamar Menezes de; CASARINI, Dulce Elena; IRIGOYEN, Maria-ClaudiaActivation of renin-angiotensin system has been linked to cardiovascular and autonomic dysfunctions in diabetes. Experiments were performed to investigate the effects of angiotensin-converting enzyme inhibitor (ACEI), enalapril, on cardiac and autonomic functions in diabetic rats. Diabetes was induced by streptozotocin (50 mg/kg), and rats were treated with enalapril (1 mg.kg(-1).d(-1)). After 30 days, evaluations were performed in control, diabetic, and enalapril-treated groups. Cardiac function was evaluated by echocardiography and through cannulation of the left ventricle (at baseline and in response to volume overload). Heart rate and systolic blood pressure variabilities were evaluated in the time and frequency domains. Streptozotocin rats had left ventricular systolic and diastolic dysfunctions, expressed by reduced ejection fraction and increased isovolumic relaxation time. The ACEI prevented these changes, improved diastolic cardiac responses to volume overload and total power of heart rate variability, reduced the ACE1 activity and protein expression and cardiac angiotensin (Ang) II levels, and increased angiotensin-converting enzyme 2 activity, despite unchanged blood pressure. Correlations were obtained between Ang II content with systolic and diastolic functions and heart rate variability. These findings provide evidence that the low-dose ACEI prevents autonomic and cardiac dysfunctions induced by diabetes without changing blood pressure and associated with reduced cardiac Ang II and increased angiotensin-converting enzyme 2 activity.
conferenceObject CARDIOVASCULAR AND METABOLIC EFFECTS OF EXERCISE TRAINING IN HIGH-FAT DIET-FED OVARIECTOMIZED MICE: COMPARISON BETWEEN MODERATE INTENSITY CONTINUOUS VS. HIGH INTENSITY INTERVAL TRAINING(2018) NASCIMENTO-CARVALHO, Bruno; SANTOS, Adriano; SANTOS, Nicolas Costa; ASSIS, Abel Pereira; IRIGOYEN, Maria-Claudia Costa; ANGELIS, Katia De; CAPERUTO, Erico Chagas; SCAPINI, Katia Bilhar; SANCHES, Iris CalladobookPart Diabetes e exercício físico(2019) D'AVILA, Kátia de Angelis Lobo; ALONSO, Denise de Oliveira; RAMIRES, Paulo Rizzo; MELO, Karla; IRIGOYEN, Maria Cláudia; SILVA, Maria Elizabeth Rossi da