MARIA CLAUDIA COSTA IRIGOYEN

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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/59 - Laboratório de Biologia Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/65, Hospital das Clínicas, Faculdade de Medicina

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Agora exibindo 1 - 10 de 32
  • conferenceObject
    COMBINED EXERCISE TRAINING ATENUATES THE ONSET OF CARDIOMETABOLIC AND AUTONOMIC DYSFUNCTIONS IN AN EXPERIMENTAL MODEL OF METABOLIC SYNDROME
    (2017) DIAS, Danielle da Silva; BERNARDES, Nathalia; CONTI, Filipe Fernandes; BRITO, Janaina de Oliveira; SANTOS, Fernando; ARAUJO, Amanda Aparecida; OLIVEIRA, Danielle Martins; FRISENE, Natalia; IRIGOYEN, Maria Claudia; ANGELIS, Katia De
  • conferenceObject
    IMPACT OF ANGIOTENSIN CONVERTING ENZYME (ACE) GENE LEVELS ON BAROREFLEX IMPAIRMENT AND SYMPATHETIC HYPERACTIVITY AFTER A HIGH FRUCTOSE DIET
    (2017) MORAES-SILVA, Ivana C.; SOUZA, Leandro E. de; CASARINI, Dulce E.; IRIGOYEN, Maria-Claudia
  • conferenceObject
    Fructose Induces Metabolic Syndrome Associated with a Marked Inflammatory State
    (2017) SANTOS, Fernando; MOREIRA, Edson Dias; ANGELIS, Katia De; IRIGOYEN, Maria Claudia
  • conferenceObject
    Wharton's Jelly-derived mesenchymal stem cells modulate autonomic activity and systemic inflammation in rats with sepsis
    (2017) CONDOR, J.; RODRIGUES, C.; MOREIRA, R.; NORONHA, I.; SANTOS, F. Dos; IRIGOYEN, M.; GOMES, S.; ANDRADE, L.
  • conferenceObject
    Dynamic resistance training improves cardiovascular autonomic variability in male hypertensive rats
    (2017) ARAUJO, Amanda; DIAS, Danielle; BERNARDES, Nathalia; CONTI, Filipe; ALLIONI, Gabriela; IRIGOYEN, Maria Claudia; ANGELIS, Katia De
  • article 9 Citação(ões) na Scopus
    Interval and continuous aerobic exercise training similarly increase cardiac function and autonomic modulation in infarcted mice
    (2017) ABAD, Cesar Cavinato Cal; NASCIMENTO, Ademir Manuel do; SANTOS, Leandro Eziquiel dos; FIGUEROA, Diego; RAMONA, Pamella; SARTORI, Michele; SCAPINI, Katie B.; ALBUQUERQUE, Oscar; MORAES-SILVA, Ivana Cinthya; COELHO-JUNIOR, Hello Jose; RODRIGUES, Bruno; MOSTARDA, Cristiano Teixeira; ANGELIS, Katia De; IRIGOYEN, Maria Claudia
    The present study aimed to compare the effects of moderate-intensity continuous and high-intensity interval exercise training (ET) on exercise tolerance, cardiac morphometry and function, hemodynamic, and cardiac autonomic modulation in myocardial infarcted mice. Wild-type mice (WT) were divided into four groups: sedentary WT (S); WT myocardium infarction sedentary (IS); WT myocardium infarction underwent to moderate-intensity continuous ET (MICT), and WT myocardium infarction underwent to high-intensity interval ET (MIIT). After 60 days of descending coronary artery ligation, moderate-intensity continuous ET consisted of running at 60% of maximum, while the high-intensity interval training consisted of eight sprints of 4 min at 80% of maximum and a 4-min recovery at 40% of maximum. Both exercises were performed 1 hr a day, 5 days a week, during 8 weeks. Results demonstrated that IS showed elevated exercise tolerance, as well as decreased hemodynamic and heart function, and autonomic control. On the other hand, both programs of ET were equally effective to increase all parameters, without further differences between the groups. In conclusion, the results of the present study showed that myocardial infarction leads to damage in both investigated strains and the two types of physical exercise attenuated the major impairments provoked by myocardial infarction in exercise tolerance, cardiac structure, cardiac function, hemodynamic and cardiac autonomic modulation.
  • conferenceObject
    WHARTON'S JELLY-DERIVED MESENCHYMAL STEM CELLS MODULATE AUTONOMIC ACTIVITY AND SYSTEMIC INFLAMMATION IN RATS WITH SEPSIS
    (2017) CONDOR, J. M.; RODRIGUES, C.; MOREIRA, R.; SANTOS, F. Dos; NORONHA, I.; IRIGOYEN, M.; GOMES, S.; ANDRADE, L.
  • article 6 Citação(ões) na Scopus
    Pretreatment with fish oil attenuates heart ischaemia consequences in rats
    (2017) SOUZA JUNIOR, Alcione Lescano de; MANCINI FILHO, Jorge; TORRES, Rosangela Pavan; IRIGOYEN, Maria Claudia; CURI, Rui
    New Findings What is the central question of this study? We investigated whether pretreatment with fish oil could prevent the major consequences of ischaemic injury to the heart. What is the main finding and its importance? Fish oil pretreatment attenuated the consequences of ischaemic injury as indicated by the small infarction area and the preservation of systolic function and coronary blood flow. These findings support the use of fish oil in order to reduce the impact of heart ischaemia. -3 Polyunsaturated fatty acid (-3 PUFA)-rich fish oil supplementation has protective effects on heart ischaemic injury. Left ventricular (LV) ischaemia was induced in rats by permanent ligation of the left descending coronary artery. Saline, fish oil or soybean oil was administered daily by gavage [3g(kg body weight)(-1)] for 20days before inducing ischaemia. Outcomes were assessed 24h after left descending coronary artery ligation. Pretreatment with fish oil decreased the -6/-3 fatty acid ratio in the LV. A reduction in infarct size and in the intensity of ventricular systolic dysfunction was found in the fish oil group compared with the saline or soybean oil groups through echocardiographic evaluation. Before infarction, LV glycogen concentrations were decreased in the fish oil group compared with the saline group. Soybean oil pretreatment led to a further increase in the LV levels of CINC-2/, IL-1 and TNF- induced by the heart infarction. In heart-infarcted rats, fish oil pretreatment decreased creatine kinase and caspase-3 activities; prevented the decrease in the coronary blood flow; increased LV contents of ATP and lactate; increased the mRNA levels of iNOS, eNOS, HIF1, GLUT1, VEGF- and p53 in the LV as measured by RT-PCR; and did not change LV pro-inflammatory cytokine concentrations compared with the control group. Fish oil protected the heart from ischaemia, as indicated by the decrease in the heart infarction area and systolic dysfunction associated with increased LV ATP concentrations and maintenance of the coronary blood flow with no change in pro-inflammatory cytokine levels.
  • conferenceObject
    OVERWEIGHT IS ASSOCIATED WITH EXACERBATED IMPAIRMENT ON HEART RATE VARIABILITY IN OFFSPRING OF HYPERTENSIVE PARENTS
    (2017) VIANA, Ariane; NASCIMENTO, Mario Cesar; PAIVA, Julia de; SANTOS, Fernando dos; CONSOLIM-COLOMBO, Fernanda Marciano; IRIGOYEN, Maria Claudia; ANGELIS, Katia De
  • article 0 Citação(ões) na Scopus
    Interval and continuous aerobic exercise training similarly increase cardiac function and autonomic modulation in infarcted mice (vol 13, pg 257, 2017)
    (2017) ABAD, Cesar Cavinato Cal; NASCIMENTO, Ademir Manuel do; SOUZA, Leandro Eziquiel de; FIGUEROA, Diego; RAMONA, Pamella; SARTORI, Michele; SCAPINI, Katia B.; ALBUQUERQUE, Oscar; MORAES-SILVA, Ivana Cinthya; COELHO-JUNIOR, Helio Jose; RODRIGUES, Bruno; MOSTARDA, Cristiano Teixeira; ANGELIS, Katia De; IRIGOYEN, Maria Claudia