DANIEL ANTUNES SILVA PEREIRA
Projetos de Pesquisa
Unidades Organizacionais
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
8 resultados
Resultados de Busca
Agora exibindo 1 - 8 de 8
- Colagenose pulmão dominante em pacientes com doença pulmonar intersticial: prevalência, estabilidade funcional e manifestações extratorácicas comuns(2015) PEREIRA, Daniel Antunes Silva; DIAS, Olivia Meira; ALMEIDA, Guilherme Eler de; ARAUJO, Mariana Sponholz; KAWANO-DOURADO, Leticia Barbosa; BALDI, Bruno Guedes; KAIRALLA, Ronaldo Adib; CARVALHO, Carlos Roberto RibeiroObjective: To describe the characteristics of a cohort of patients with lung-dominant connective tissue disease (LD-CTD). Methods: This was a retrospective study of patients with interstitial lung disease (ILD), positive antinuclear antibody (ANA) results (>= 1/320), with or without specific autoantibodies, and at least one clinical feature suggestive of connective tissue disease (CO). Results: Of the 1,998 patients screened, 52 initially met the criteria for a diagnosis of LD-CTD: 37% were male; the mean age at diagnosis was 56 years; and the median follow-up period was 48 months. During follow-up, 8 patients met the criteria for a definitive diagnosis of a CTD. The remaining 44 patients comprised the LD-CTD group, in which the most prevalent extrathoracic features were arthralgia, gastroesophageal reflux disease, and Raynaud's phenomenon. The most prevalent autoantibodies in this group were ANA (89%) and anti-SSA (anti-Ro, 27%). The mean baseline and final FVC was 69.5% and 74.0% of the predicted values, respectively (p > 0.05). Nonspecific interstitial pneumonia and usual interstitial pneumonia patterns were found in 45% and 9% of HRCT scans, respectively; 36% of the scans were unclassifiable. A similar prevalence was noted in histological samples. Diffuse esophageal dilatation was identified in 52% of HRCT scans. Nailfold capillaroscopy was performed in 22 patients; 17 showed a scleroderma pattern. Conclusions: In our LD-CTD group, there was predominance of females and the patients showed mild spirometric abnormalities at diagnosis, with differing underlying ILD patterns that were mostly unclassifiable on HRCT and by histology. We found functional stability on follow-up. Esophageal dilatation on HRCT and scleroderma pattern on nailfold capillaroscopy were frequent findings and might come to serve as diagnostic criteria.
conferenceObject Evaluation and correlations of the extension of pulmonary cysts in lymphangioleiomyomatosis(2013) ARAUJO, Mariana Sponholz; FREITAS, Carolina Salim Goncalves; BALDI, Bruno Guedes; TELES, Gustavo Borges da Silva; PIMENTA, Suzana Pinheiro; PEREIRA, Daniel Antunes Silva; DIAS, Olivia Meira; COSTA, Andre Nathan; KAWANO-DOURADO, Leticia; KAWASSAKI, Alexandre; KAIRALLA, Ronaldo Adib; CARVALHO, Carlos Roberto Ribeiro- Linfadenomegalia e febre em chefe de cozinha durante viagem à Europa(2015) KAWANO-DOURADO, Leticia; PEIRERA, Daniel Antunes Silva; KAWASSAKI, Alexandre de Melo; DOLHNIKOFF, Marisa; SILVA, Marcos Vinicius da; KAIRALLA, Ronaldo AdibThis case illustrates a rare presentation (as lymphadenopathy and fever) of one of the most common zoonotic diseases worldwide brucellosis in a 22-year-old Brazilian male (a chef) who had recently returned to Brazil after having lived in and traveled around Europe for one year. The histopathology, clinical history, and response to treatment were all consistent with a diagnosis of brucellosis, which was confirmed by PCR in a urine sample. We also review some aspects of brucellosis, such as the clinical features, diagnosis, and management.
- What if my lung-dominant connective tissue disease (LD-CTD) patient eventually met criteria for a definite CTD: The role of prognosis!(2015) PEREIRA, Daniel Antunes Silva; DIAS, Olivia Meira; ARAUJO, Mariana Sponholz; KAWANO-DOURADO, Leticia; FREITAS, Carolina Salim; KAWASSAKI, Alexandre De Melo; GRATZIOU, Bruno; CARVALHO, Carlos R. R.; KAIRALLA, Ronaldo Adib
conferenceObject Interstitial Lung Disease As A Marker Of Systemic Autoimmunity: Repeated Autoantibody Measure Can Uncover An Occult Connective Tissue Disease(2014) PEREIRA, D. A. S.; BALDI, B. G.; KAWASSAKI, A. M.; KAWANO-DOURADO, L.; DIAS, O. M.; FREITAS, C. S. G.; ARAUJO, M. S.; KAIRALLA, R. A.; CARVALHO, C. R. R.conferenceObject Features Of A Brazilian Cohort Of Patients With Lung-Dominant Connective Tissue Disease (ld-CTd)(2013) PEREIRA, D. A. S.; DIAS, O. M.; ALMEIDA, G. E.; ARAUJO, M. S.; KAWANO-DOURADO, L.; KAIRALLA, R. A.; CARVALHO, C. R. R.; BALDI, B. G.conferenceObject Retrospective Cohort Of Neurosarcoidosis Patients From A Reference Center In Brazil: The Underestimation Of A Relevant Feature(2014) FELISBINO, M. B.; PEREIRA, D. A. S.; COSTA, A. N.; ARAUJO, M. S.; KAWASSAKI, A. M.; FREITAS, C. S.; KAWANO-DOURADO, L.; DIAS, O. M.; BALDI, B. G.; KAIRALLA, R. A.conferenceObject A Retrospective Cohort Study Comparing Autoantibody Positive Idiopathic Interstitial Pneumonia Patients With And Without Extrathoracic Features Of Connective Tissue Disease(2014) PEREIRA, D. A. S.; ALMEIDA, G. E.; FREITAS, C. S.; DIAS, O. M.; ARAUJO, M. S.; KAWANO-DOURADO, L.; KAWASSAKI, A. M.; BALDI, B. G.; CARVALHO, C. R. R.; KAIRALLA, R. A.