CESAR AUGUSTO CAPORRINO PEREIRA
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
6 resultados
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bookPart Diabetes mellitus(2022) PEREIRA, Cesar Augusto Caporrino; GOMES, Brenno Rizerio- Influenza vaccination strategy in acute coronary syndromes: the VIP-ACS trial(2022) FONSECA, Henrique Andrade R.; FURTADO, Remo Holanda M.; ZIMERMAN, Andre; LEMOS, Pedro A.; FRANKEN, Marcelo; MONFARDINI, Frederico; PEDROSA, Rodrigo P.; PATRIOTA, Rodrigo de Lemos S.; PASSOS, Luiz Carlos S.; DALL'ORTO, Frederico Toledo C.; HOFFMANN FILHO, Conrado R.; NASCIMENTO, Bruno Ramos; BALDISSERA, Felipe A.; PEREIRA, Cesar Augusto C.; CARAMORI, Paulo Ricardo A.; ANDRADE, Pedro Beraldo de; ESTEVES, Carlos; SALIM, Elke Ferreira; SILVA, Jefferson Henrique da; PEDRO, Izabela Chave; SILVA, Mariana Castaldi R.; PEDRI, Ewerton Hernandes de; CARIOCA, Ana Carla R. D.; PIANO, Luciana Pereira A. de; ALBUQUERQUE, Camila Santos N.; MOIA, Diogo D. F.; MOMESSO, Roberta Grazzielli R. A. P.; MACHADO, Felipe P.; DAMIANI, Lucas P.; SOARES, Ronaldo Vicente P.; SCHETTINO, Guilherme P.; V, Luiz Rizzo; NICOLAU, Jose Carlos; BERWANGER, OtavioAims To evaluate whether a strategy of double-dose influenza vaccination during hospitalization for an acute coronary syndrome (ACS) compared with standard-dose outpatient vaccination (as recommended by current guidelines) would further reduce the risk of major cardiopulmonary events. Methods and results Vaccination against Influenza to Prevent cardiovascular events after Acute Coronary Syndromes (VIP-ACS) was a pragmatic, randomized, multicentre, active-comparator, open-label trial with blinded outcome adjudication comparing two strategies of influenza vaccination following an ACS: double-dose quadrivalent inactivated vaccine before hospital discharge vs. standard-dose quadrivalent inactivated vaccine administered in the outpatient setting 30 days after randomization. The primary outcome was a hierarchical composite of all-cause death, myocardial infarction, stroke, unstable angina, hospitalization for heart failure, urgent coronary revascularization, and hospitalization for respiratory causes, analysed by the win ratio method. Patients were followed for 12 months. During two influenza seasons, 1801 participants were included at 25 centres in Brazil. The primary outcome was not different between groups, with 12.7% wins in-hospital double-dose vaccine group and 12.3% wins in the standard-dose vaccine group {win ratio: 1.02 [95% confidence interval (CI): 0.79-1.32], P = 0.84}. Results were consistent for the key secondary outcome, a hierarchical composite of cardiovascular death, myocardial infarction and stroke [win ratio: 0.94 (95% CI: 0.66-1.33), P = 0.72]. Time-to-first event analysis for the primary outcome showed results similar to those of the main analysis [hazard ratio 0.97 (95% CI: 0.75-1.24), P = 0.79]. Adverse events were infrequent and did not differ between groups. Conclusion Among patients hospitalized with an ACS, double-dose influenza vaccination before discharge did not reduce cardiopulmonary outcomes compared with standard-dose vaccination in the outpatient setting.
- COVID-19 Myocarditis Mimicking ST-Segment Elevation Myocardial Infarction(2022) CONCEICAO, Anthony Medina; PEREIRA, Cesar A. C.; RAHAL, Maria Julia; ISHIKAWA, Walther Yoshiharu; ROCHITTE, Carlos E.
- Effects of DPP4 Inhibitor in Platelet Reactivity and Other Cardiac Risk Markers in Patients with Type 2 Diabetes and Acute Myocardial Infarction(2022) GENESTRETI, Paulo R. Rizzo; FURTADO, Remo H. M.; SALSOSO, Rocio; DALCOQUIO, Talia F.; FRANCI, Andre; MENEZES, Fernando R.; CAPORRINO, Cesar; FERRARI, Aline G.; NAKASHIMA, Carlos A. K.; SCANAVINI FILHO, Marco A.; LIMA, Felipe G.; V, Roberto R. C. Giraldez; BARACIOLI, Luciano M.; NICOLAU, Jose C.Background: The management of acute myocardial infarction (AMI) presents several challenges in patients with diabetes, among them the higher rate of recurrent thrombotic events, hyperglycemia and risk of subsequent heart failure (HF). The objective of our study was to evaluate effects of DPP-4 inhibitors (DPP-4i) on platelet reactivity (main objective) and cardiac risk markers. Methods: We performed a single-center double-blind randomized trial. A total of 70 patients with type 2 diabetes (T2DM) with AMI Killip <= 2 on dual-antiplatelet therapy (aspirin plus clopidogrel) were randomized to receive sitagliptin 100 mg or saxagliptin 5 mg daily or matching placebo. Platelet reactivity was assessed at baseline, 4 days (primary endpoint) and 30 days (secondary endpoint) after randomization, using VerifyNow Aspirin (TM) assay, expressed as aspirin reaction units (ARUs); B-type natriuretic peptide (BNP) in pg/mL was assessed at baseline and 30 days after (secondary endpoint). Results: Mean age was 62.6 +/- 8.8 years, 45 (64.3%) male, and 52 (74.3%) of patients presented with ST-segment elevation MI. For primary endpoint, there were no differences in mean platelet reactivity (p = 0.51) between the DPP-4i (8.00 {-65.00; 63.00}) and placebo (-14.00 {-77.00; 52.00}) groups, as well in mean BNP levels (p = 0.14) between DPP-4i (-36.00 {-110.00; 15.00}) and placebo (-13.00 {-50.00; 27.00}). There was no difference between groups in cardiac adverse events. Conclusions: DPP4 inhibitor did not reduce platelet aggregation among patients with type 2 diabetes hospitalized with AMI. Moreover, the use of DPP-4i did not show an increase in BNP levels or in the incidence of cardiac adverse events. These findings suggests that DPP-4i could be an option for management of T2DM patients with acute MI.
conferenceObject The Effect of Current Smoking on Platelet Reactivity Measures by Point-of-Care Methods in Patients Treated With and Without Clopidogrel(2022) NICOLAU, Jose C.; SALSOSO, Rocio; DALCOQUIO, Talia; GURBEL, Paul A.; TANTRY, Udaya; GIUGLIANO, Robert; NAKASHIMA, Carlos A.; FRANCI, Andre; RIZZO, Paulo; MENEZES, Fernando; GUARDIEIRO, Bruno; SCANAVINI FILHO, Marco Antonio; FERRARI, Aline G.; PEREIRA, Cesar; ARANTES, Flavia B.; BARBOSA, Carlos; BERTOLIN, Adriadne; FURTADO, RemoconferenceObject In-Hospital and Long-Term Impact of Right and Left Bundle-Branch Block in Mortality in Patients With Acute Myocardial Infarction(2022) NICOLAU, Jose C.; BERTOLIN, Adriadne; JULIASZ, Marcela; CHIU, Felipe; BARACIOLI, Luciano; LIMA, Felipe; GIRALDEZ, Roberto R.; PEREIRA, Cesar; ANDRADE, Maria; RIBEIRO, Andre; QUINTANILHA, Nadia; SANTOS, Glaylton; ESPINOZA, Cristhian V.; FURTADO, Remo