NEUSA YURIKO SAKAI VALENTE
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/53 - Laboratório de Micologia, Hospital das Clínicas, Faculdade de Medicina
LIM/53 - Laboratório de Micologia, Hospital das Clínicas, Faculdade de Medicina
7 resultados
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Agora exibindo 1 - 7 de 7
- Cutaneous metastasis of follicular thyroid carcinoma mimicking pyogenic granuloma [Metástase cutânea de carcinoma folicular de tireóide mimetizando granuloma piogênico](2018) RIBEIRO, C. P.; SILVA, F. O. da; DINIZ, T. A. C. B.; PIRES, M. C.; VALENTE, N. Y. S.O carcinoma folicular de tireóide é um tumor bem diferenciado, considerado o segundo subtipo mais comum de câncer de tireóide. Sua metástase geralmente ocorre por via hematogênica, principalmente para pulmões e ossos, porém é rara quando cutânea. Relatamos caso de paciente com carcinoma folicular de tireóide há 5 anos que percebeu lesão nodular exofítica de 1cm, eritematosa, friável no couro cabeludo com 7 meses de evolução, simulando granuloma piogênico. A biópsia revelou adenocarcinoma com diferenciação glandular e material coloide no lúmen. O perfil imuno-histoquímico foi positivo para CK-7 e tireoglobulina, favorecendo o diagnóstico de metástase cutânea de neoplasia primária da tireóide. © 2018 Sociedade Brasileira de Dermatologia.Follicular thyroid carcinoma is a well-differentiated tumor, and is considered the second most common subtype of thyroid cancer. Its metastasis usually arises hematogenously - mainly to the lungs and bones - and is considered rare when it occurs cutaneously. The authors report a case of a patient with follicular thyroid carcinoma for 5 years who noticed an erythematous, friable exophytic nodular lesion measuring 1cm on the scalp with 7 months of development, simulating a pyogenic granuloma. Biopsy analysis revealed an adenocarcinoma with glandular differentiation and colloid material in the lumen. The immunohistochemical profile was positive for CK-7 and thyroglobulin, favoring the diagnosis of cutaneous metastasis of primary thyroid neoplasia. © 2018 Sociedade Brasileira de Dermatologia.
- Areata-Like Lupus as a Clinical Manifestation of Cutaneous Lupus Erythematosus(2022) MORAIS, K. L.; SECCHIN, P.; ANZAI, A.; VERUSSA, M. J. M. C.; MUNCK, A.; FECHINE, C. O. C.; VALENTE, N. Y. S.; ROMITI, R.Introduction: Lupus erythematosus (LE) is a chronic autoimmune disease that frequently causes hair loss and scalp lesions. Hair loss can be scarring and nonscarring, diffuse, or patchy. The nonscarring patchy alopecia is usually related to systemic LE (SLE) and may simulate alopecia areata (AA), reason why it is named areata-like lupus. Our case was diagnosed with areata-like lupus but did not meet criteria for SLE. Case Report: A 63-year-old woman presented with irregular nonscarring patchy alopecia in the temporal and frontoparietal scalp. Trichoscopy showed exclamation mark hairs, vellus hairs, and sparse yellow dots. Histology revealed epidermal vacuolar interface dermatitis, lymphohistiocytic infiltrate around the bulbs of anagen follicles, and eccrine glands. Direct immunofluorescence showed deposits of C3, IgA, and IgG in the basement membrane zone. Discussion: Patients with cutaneous LE can also manifest as nonscarring patchy alopecia that is clinically similar to AA, despite the absence of systemic manifestations. Areata-like lupus is secondary to the lupus autoimmune infiltrate that affects the skin including the hair follicles. Trichoscopy, histology, and direct immunofluorescence are important to differentiate this form of alopecia from AA, which is believed to have a higher incidence in lupus patients.
- Poroid hidradenoma: A rare adnexa tumor(2018) ABUAWAD, Y. G.; SILVA, F. O. da; PORTOCARRERO, L. K. L.; DINIZ, T. A. C. B.; WESTIN, A. T.; VALENTE, N. Y. S.The poroid hidradenoma is a rare benign intradermal neoplasm rare that is poorly described in the literature. It usually affects elderly individuals and is characterized as a solitary, painless and well-circumscribed nodule. The diagnosis is confirmed by the histological characteristics of the hidradenomas and poromas. The treatment corresponds to complete surgical excision, thus avoiding recurrence and malignancy. The authors report a case of a 64 year-old patient, with a single, well-delimited and asymptomatic nodular lesion that had emerged 5 months before. © 2018 Sociedade Brasileira de Dermatologia.O hidradenoma poroide é uma neoplasia intradérmica benigna rara e pouco descrita na literatura. Afeta geralmente indivíduos idosos e caracteriza-se como nódulo solitário, indolor e bem circunscrito. O diagnóstico é firmado por características histológicas de hidradenomas e poromas. O tratamento é realizado através de excisão cirúrgica completa, evitando assim recidiva e malignização. Relatamos caso de uma paciente, 64 anos, com lesão nodular única, bem delimitada e assintomática há 5 meses. © 2018 Sociedade Brasileira de Dermatologia.
- Methotrexate for refractory adult atopic dermatitis leads to alterations in cutaneous IL-31 and IL-31RA expression(2024) SAMORANO, Luciana Paula; MANFRERE, Kelly Cristina Gomes; PEREIRA, Naiura Vieira; TAKAOKA, Roberto; VALENTE, Neusa Yuriko Sakai; SOTTO, Mirian Nacagami; SILVA, Luiz Fernando Ferraz; SATO, Maria Notomi; AOKI, ValeriaBackground: Methotrexate (MTX) is an alternative treatment for patients with moderate/severe atopic dermatitis (AD). Objective: The authors evaluated the effect of MTX on the cutaneous expression of cytokines and chemokines that are involved in the inflammatory response in adult AD patients who received treatment with methotrexate for 24 weeks. Methods: The authors conducted a prospective single-institution cohort study with 12 adults with moderate/severe AD who received oral MTX (15 mg/wk for 24 wks) and 10 non-atopic matched controls. The comparison was made of skin biopsies of lesional and non-lesional skin, pre- and post MTX treatment. The authors analyzed mean epidermal thickness and expression of IL-31, IL-31RA, OSMR, TSLP, Ki67, IL-4 mRNA, IL-6, IL-10, TNF-alpha, IFN-gamma, TARC, and CCL-22. Results: There was a reduction in mean epidermal thickness (p = 0.021), an increase in IL-31RA expression (immunohistochemistry) in the epidermis (p = 0.016) and a decrease in IL-31 gene expression (p = 0.019) on lesional AD skin post-MTX treatment. No significant changes in the cutaneous expression of the other evaluated markers were identified. Study limitations: Small sample size and limited length of follow-up. Conclusions: Treatment with MTX in adults with moderate/severe AD reduced epidermal hyperplasia and changed the cutaneous expression of inflammatory cytokines and receptors that are mainly related to pruritus, including IL-31 and IL-31RA. (c) 2023 Published by Elsevier Espana, S.L.U. on behalf of Sociedade Brasileira de Dermatologia. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Porokeratoma: A new clinical entity? [Poroqueratoma: Uma nova entidade clínica?](2018) SILVA, F. O. da; DINIZ, T. A. C. B.; ABUAWAD, Y. G.; BARBOSA, M. A. H.; SARAIVA, M. I. R.; CUNHA, T. A. C.; VALENTE, N. Y. S.O poroqueratoma é entidade definida como acantoma com características de poroceratose. Apresenta padrão histopatológico distinto de lamela cornóide e diferenças clínicas em relação à poroceratose típica. Trata-se de uma afecção recentemente descrita, com poucos casos relatados na literatura. Apresentamos caso de paciente do sexo masculino, 46 anos, com lesão nodular exofítica, localizada na região interglútea. O exame histopatológico evidenciou múltiplas lamelas cornóides, sendo as periféricas as mais bem definidas. Devido à apresentação clínica e histopatológica, o diagnóstico foi de poroqueratoma. © 2018 Sociedade Brasileira de Dermatologia.Porokeratoma is an entity defined as an acanthoma with porokeratosis characteristics. It has a distinct histological pattern from that of the cornoid lamella and has clinical differences regarding the typical porokeratosis. The condition has been described only recently and there are few cases reported in the literature. The authors report the case of a 46 year-old male patient with an exophytic nodular lesion located in the intergluteal region. Histological examinations evidenced multiple cornoid lamellae, with those located on the periphery being better defined. Based on the clinical and histological appearance, the lesion was diagnosed as a porokeratoma. © 2018 Sociedade Brasileira de Dermatologia.
- Sensitive Scalp and Trichodynia: Epidemiology, Etiopathogenesis, Diagnosis, and Management(2023) SOUZA, Emilly Neves; ANZAI, Alessandra; FECHINE, Carolina Oliveira Costa; VALENTE, Neusa Yuriko Sakai; ROMITI, RicardoSensitive scalp (SSc) is considered a sensitive skin on the scalp, with its particularities. Although it is not rare in the dermatological practice and the term is commonly present in personal care products, this entity is poorly investigated in the medical literature. The etiopathogenesis is still uncertain, and the sensitivity may be associated with hair loss. Clinical manifestations are subjective symptoms of pruritus, burning, pain, pricking, and/or trichodynia, often with scalp erythema. SSc can be triggered by several factors (endogenous or exogenous). The diagnosis is guided by the anamnesis, and there are still no specific trichoscopic features. Trigeminal trophic syndrome and postherpetic neuralgia are the main differential diagnosis to be considered. We organized the therapeutical approach in three steps: scalp care, topical and systemic treatment.
- Correlation of clinical, histopathologic, and direct immunofluorescence findings in lesional and nonlesional scalp of frontal fibrosing alopecia and lichen planopilaris – An observational study(2023) DOCHE, I.; VALENTE, N.; SOTTO, M. N.; RIVITTI-MACHADO, M. C.; AOKI, V.; GERLERO, P.; HORDINSKY, M. K.