LUCIANA PARENTE COSTA SEGURO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
15 resultados
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Agora exibindo 1 - 10 de 15
conferenceObject Induction of Lupus Nephritisin in Real Situation: Cyclophosphamide or Mycophenolate Mofetil?(2017) MUNHOZ, Gabriela; LACERDA, Maira; LOPES, Michelle; BORBA, Eduardo Ferreira; SEGURO, Luciana; BONFA, EloisaconferenceObject Bone Metabolism Impairment in Heart Transplant: Results from a Prospective Cohort Study(2019) SEGURO, Luis; PEREIRA, Rosa; SEGURO, Luciana; CAPARBO, Valeria; AVILA, Monica; MANGINI, Sandrigo; CAMPOS, Iascara; GAIOTTO, Fabio; MARCONDES-BRAGA, Fabiana; BACAL, Fernando- Profiles of criteria and non-criteria anti-phospholipid autoantibodies are associated with clinical phenotypes of the antiphospholipid syndrome(2020) VOLKOV, Ilan; SEGURO, Luciana; LEON, Elaine P.; KOVACS, Laszlo; ROGGENBUCK, Dirk; SCHIERACK, Peter; GILBURD, Boris; DORIA, Andrea; TEKTONIDOU, Maria G.; AGMON-LEVIN, NancyBackground Specific anti-phospholipids antibodies (aPLs) are used as classification criteria of the antiphospholipid syndrome (APS). These aPLs, although essential for diagnosis, do not predict disease phenotypes, which may require specific therapies. Non-criteria aPLs are rarely evaluated and their role is yet to be defined. In the current study, we aimed to examine the association between criteria and non-criteria aPLs and APS phenotypes. Methods Serum samples from 188 subjects, 130 APS patients and 58 controls were analyzed for the presence of 20 aPLs (IgG and IgM isotypes to cardiolipin (CL), beta2-glycoprotein1 (beta 2GP1), phosphatidic acid (P-acid), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylglycerol (PG), phosphatidylinositol (PI), phosphatidylserine (PS), annexin-5 (AN) and prothrombin (PT) using a line immunoassay (GA Generic Assays, Germany). Sero-positivity to the different aPLs/aPLs profiles was correlated to APS phenotypes (i.e. arterial thrombosis, CNS manifestations, venous thrombosis, relapsing disease, obstetric morbidity). Results In this cohort, arterial thrombosis was associated with accumulative number of >= 7/20 aPLs evaluated (OR 4.1; CI 95% 1.9-96, p = 0.001) as well as the sole presence of aPT (IgG) (OR 2.3;CI 95% 1.1-5.1, p = 0.03). CNS manifestations were linked with a profile of 4 aPLs (IgG): aPT, aPG, aPI and aAN (OR 2.6;CI 95% 1.1-6.3, p = 0.03). Symptom-free period of >= 3 years was linked with lower number of aPLs and the presence of aPI (IgG) (OR 3.0;CI 95% 1.08-8.1, p < 0.05) or aAN (IgG) (OR 3.4;CI 95% 1.08-10.9, p < 0.05). APS related pregnancy morbidity correlated with a profile of 2 aPLs (IgG): aCL and aPS (OR 2.9; CI 95% 1.3-6.5, p < 0.05) or the sole presence of aAN (IgG) (OR 2.8; CI 95% 1.02-8, p = 0.05). Conclusion In this study, we observed an association between specific criteria/non-criteria aPLs or aPLs profiles and clinical phenotypes of APS. Our data suggest that examination of a wider variety of aPLs may allow better characterization of APS.
conferenceObject Anti-beta 2GP1-Domain-1 Antibodies Are a Marker Of APS Severity(2013) AGMON-LEVIN, Nancy; SEGURO, Luciana; ROSARIO, Cristina; MAHLER, Michael; GATTO, Mariele; TOMER, Nir; LEON, Elaine P.; DORIA, Andrea; KOVACS, Laszlo; COSTEDOAT-CHALUMEAU, Nathalie; GILBURD, Boris; SHOENFELD, YehudaconferenceObject Visceral Adiposity Assessed By DXA in Juvenile-Onset Systemic Lupus Erythematosus: A Correlation with Damage Index and Disease Duration(2016) PAUPITZ, Juliane; LIMA, Glauce; AIKAWA, Nadia E.; TAKAYAMA, Liliam; SEGURO, Luciana; BONFA, Eloisa; PEREIRA, Rosa M. R.conferenceObject Early and Late Onset Biopsy Proven Lupus Nephritis without Other Associated Autoimmune Diseases: Severity and Long-Term Outcome(2017) LOPES, Michelle; SANTOS, Laryssa; SEGURO, Luciana; BONFA, EloisaconferenceObject Lower P1NP Serum Levels: a Predictive Marker of Bone Loss after One-Year Follow-up in premenopausal SLE Patients.(2014) SEGURO, Luciana; CASELLA, Caio B.; CAPARBO, Valeria; OLIVEIRA, Ricardo M.; BONFA, Alessandra C.; BONFA, Eloisa; PEREIRA, Rosa M. R.conferenceObject Early Proteinuria Response in Real Life Situation Predicts Long-Term Lupus Renal Outcome in Ethnically Diverse Group with Biopsy-Proven Nephritis(2016) LOPES, Michelle; SEGURO, Luciana; CASTRO, Maite; DAFFRE, Danielle; BORBA, Eduardo Ferreira; BONFA, EloisaconferenceObject Effectiveness of Renoprotective Approaches in Lupus Nephritis: More Than Just Immunosuppression(2015) CASTRO, Maite; BORBA, Eduardo Ferreira; LOPES, Michelle; PASOTO, Sandra G.; BONFA, Eloisa; SEGURO, LucianaconferenceObject Chronic Arthritis in Systemic Lupus Erythematosus: Distinct Features in 336 Pediatric and 1,830 Adult Patients(2015) GORMEZANO, Natali W.; SILVA, Clovis A.; AIKAWA, Nadia E.; BARROS, Diego L.; SILVA, Mariana A. da; OTSUZI, Carini I.; KOZU, Katia T.; SEGURO, Luciana; PEREIRA, Rosa M. R.; BONFA, Eloisa