LUCIANA PARENTE COSTA SEGURO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject CLINICAL AND SEROLOGICAL COMPARATIVE ANALYSIS OF SYSTEMIC SCLEROSIS WITH OR WITHOUT OVERLAP SYNDROMES IN A LARGE BRAZILIAN COHORT(2014) SILVA, C. M.; PASOTO, S. G.; VIANA, V. S.; SEGURO, L. P. C.; ANDRADE, D. C. O.; BONFA, E.; SAMPAIO-BARROS, P. D.article 4 Citação(ões) na Scopus Hypomagnesaemia and hypocalcaemia in a patient with systemic sclerosis: role of proton pump inhibitors(2014) PEREZ, M. O.; NEVES, E. F. V.; BORTOLAI, C. B. C.; SAMPAIO-BARROS, P. D.; ANDRADE, D. C. O.; SEGURO, L. P. C.Proton pump inhibitors (PPI) are widely used in patients with systemic sclerosis (SSc) due to the chronic gastroesophageal reflux. The authors report a female patient with a 9-year history of SSc and long-term use of omeprazole, who complained of paresthesia and asthenia for 12 months. Physical examination revealed clinical signs of hypocalcaemia confirmed by laboratory tests that also showed hypomagnesaemia. After exclusion of possible causes, hypomagnesaemia secondary to PPI was diagnosed and omeprazole was replaced by a histamine H2-receptor antagonist: ranitidine. Despite continuous magnesium supplementation, the reintroduction of PPI at a lower dose due to worsening of dyspeptic symptoms led to recurrence of hypomagnesaemia. After definitive suspension of PPI, reintroduction of ranitidine and optimisation of anti-reflux environmental measures, the patient stabilised. In conclusion, SSc patients using PPIs should have their magnesium and calcium serum levels measured periodically, and non-specific symptoms such as asthenia, generalised paresthesia or life-threatening manifestations (seizures, arrhythmias) should not be neglected.conferenceObject Lower P1NP Serum Levels: a Predictive Marker of Bone Loss after One-Year Follow-up in premenopausal SLE Patients.(2014) SEGURO, Luciana; CASELLA, Caio B.; CAPARBO, Valeria; OLIVEIRA, Ricardo M.; BONFA, Alessandra C.; BONFA, Eloisa; PEREIRA, Rosa M. R.- CLINICAL AND SEROLOGICAL COMPARATIVE ANALYSIS OF SYSTEMIC SCLEROSIS WITH OR WITHOUT OVERLAP SYNDROMES IN A LARGE BRAZILIAN COHORT(2014) SILVA, C. M.; VIANA, V. S.; PASOTO, S. G.; SEGURO, L. P.; ANDRADE, D. C. O.; BONFA, E.; SAMOIO-BARROS, P. D.
- Acute physical exercise is safe in patients with primary antiphospholipid syndrome with exclusive venous thrombosis and under oral anticoagulation with warfarin(2014) GARCIA, Carolina Borges; SEGURO, Luciana Parente Costa; PERANDINI, Luiz Augusto; PINTO, Ana Lucia de Sa; LIMA, Fernanda Rodrigues; NEGRAO, Carlos Eduardo; BONFA, Eloisa; BORBA, Eduardo FerreiraThe purpose of present study was to evaluate the effects of maximal acute physical exercise on prothrombin time/international normalized ratio (PT/INR) in patients with primary antiphospholipid syndrome (PAPS) under oral anticoagulation with warfarin and the safety of acute exercise in regard to thrombosis and bleeding risk. Eighteen physically inactive women with PAPS (Sydney criteria) with exclusive venous events and without thrombocytopenia were included. All patients were under stable warfarin therapy (PT/INR target: 2.0-3.0). Eighteen age-matched healthy sedentary women without thrombosis/bleeding disorders were selected as controls. All subjects performed a maximal exercise test, and capillary blood samples were obtained pre-, post- and at 1-h post-exercise (recovery time) for PT/INR analysis using a portable CoaguCheck. PAPS patients and controls had similar mean age (31.50 +/- A 8.06 vs. 29.61 +/- A 7.05 years, p = 0.46) and body mass index (24.16 +/- A 3.67 vs. 24.66 +/- A 2.71 kg/m(2), p = 0.65). PAPS had a mild but significant increase in PT/INR value at 1-h post-exercise (recovery) compared with pre- (2.33 +/- A 0.34 vs. 2.26 +/- A 0.29, p = 0.001) and post-exercise (2.33 +/- A 0.34 vs. 2.26 +/- A 0.32, p = 0.001) that was observed in 61.11 % of these patients. None of the subjects had thrombotic or bleeding complications related to the acute exercise. Acute exercise in patients with PAPS with exclusive venous thrombosis was safe with a minor increase in PT/INR. This is an important step to introduce regular exercise training as a therapeutic tool in the management of these patients.
article 0 Citação(ões) na Scopus Kidney biopsy is mandatory in cases of silent arterial hypertension in scleroderma renal crisis: a case report(2014) KOBAYASHI, C. B. C.; BENTO, R. H.; MALHEIROS, D. M. A. C.; ANDRADE, D.; SEGURO, L. C. P.; SAMPAIO-BARROS, P. D.conferenceObject RANKL and OPG Gene Polymorphisms: Association with Vertebral Fractures and Bone Mineral Density in Premenopausal Systemic Lupus Erythematosus.(2014) BONFA, Alessandra C.; SEGURO, Luciana P. C.; CAPARBO, Valeria; BONFA, Eloisa; PEREIRA, Rosa M. R.conferenceObject ENVIRONMENTAL FACTORS AND INDUCTION OF SYSTEMIC SCLEROSIS: ANALYSIS OF 211 CONSECUTIVE PATIENTS(2014) SAMPAIO-BARROS, P.; AQUILA, L.; MEDEIROS, A. C.; SEGURO, L.; ANDRADE, D.conferenceObject INFLUENCE OF GENDER, ETHNICITY AND AGE AT ONSET IN THE CLINICAL PRESENTATION OF SYSTEMIC SCLEROSIS IN A LARGE BRAZILIAN COHORT OF 1017 PATIENTS(2014) SAMPAIO-BARROS, P.; MARANGONI, R.; ROCHA, L.; BORTOLUZZO, A.; SEGURO, L.; RIO, A. P. Del; ANDRADE, D.; NASCIMENTO, I.; FOELKEL, A. L.; MARQUES-NETO, J. F.- Spondyloptosis in athlete(2014) ASSAD, Ana Paula Luppino; ABREU, Andressa Silva; SEGURO, Luciana Parente Costa; GUEDES, Lissiane Karine Noronha; LIMA, Fernanda Rodrigues; PINTO, Ana Lucia de SaThe adolescent athletes are at greater risk of low back pain and structural spine injuries. Spondylolysis is responsible for the majority of back pain cases in young athletes, rarely occurring in adults. We report a case of a 13-year-old judo female athlete, who came to our service with 5 months of progressive low back pain during training which was initially attributed to mechanical causes, without any further investigation by imaging methods. At admission, the patient had lumbar deformity, antalgic posture and bilaterally positive unipodalic lumbar hyperextension maneuver. After a research which showed spondyloptosis, the patient underwent surgery. In this article, we discuss, based on this case report, the diagnostic approach to low back pain in young athletes, since the complaint of chronic back pain can be a marker of a structural lesion that may be permanent and bring irreversible functional loss.