NATHALIA CAROLINE SANTIAGO E SOUZA
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina
LIM/52 - Laboratório de Virologia, Hospital das Clínicas, Faculdade de Medicina
LIM/52 - Laboratório de Virologia, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
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conferenceObject A COHORT STUDY TO DETERMINE THE INCIDENCE OF ZIKA VIRUS INFECTION AMONG NEWBORNS, SANTOS, BRAZIL, 2016-2017(2017) LUNA, Expedito J.; ROMANO, Camila M.; ARAUJO, Evaldo S.; LEVI, Jose E.; OLIVEIRA, Olimpia N.; FERNANDES, Luis R.; FELIX, Alvina C.; SOUZA, Nathalia S.; FERNANDES, Joao H.; CAMPOS, Sergio R.; FRAGOSO, Danielli B.; PANNUTI, Claudio S.conferenceObject RE-EMERGENCE OF DENV-2 IN THE STATE OF SAO PAULO, BRAZIL(2019) LUNA, Expedito J.; FIGUEIREDO, Gerusa M.; CAMPOS, Sergio R.; LEVI, Jose E.; FIGUEIREDO, Walter M.; COSTA, Angela A.; FELIX, Alvina C.; SOUZA, Nathalia S.; PANNUTI, Claudio S.conferenceObject ESTIMATING THE UNDERREPORTING OF DENGUE CASES, ARARAQUARA, BRAZIL, 2015(2017) LUNA, Expedito J.; FIGUEIREDO, Gerusa M.; CAMPOS, Sergio R.; LEVI, Jose E.; FIGUEIREDO, Walter M.; COSTA, Angela A.; FELIX, Alvina C.; SOUZA, Nathalia S.; CARDOSO, Maria R.; PANNUTI, Claudio S.conferenceObject INAPPARENT DENGUE VIRUS INFECTION INCIDENCE, SAO PAULO, BRAZIL, 2014-2015(2017) LUNA, Expedito J.; FIGUEIREDO, Gerusa M.; CAMPOS, Sergio R.; LEVI, Jose E.; FIGUEIREDO, Walter M.; COSTA, Angela A.; FELIX, Alvina C.; SOUZA, Ana C.; SOUZA, Nathalia C.; CARDOSO, Maria R.; PANNUTI, Claudio S.conferenceObject DENGUE COHORT STUDY, ARARAQUARA, BRAZIL, 2015, BASELINE SEROPREVALENCE(2015) LUNA, Expedito J.; FIGUEIREDO, Gerusa M.; LEVI, Jose E.; FIGUEIREDO, Walter M.; COSTA, Angela A.; CAMPOS, Sergio R.; FELIX, Alvina C.; SOUZA, Ana C.; SOUZA, Nathalia C.; CARDOSO, Maria R.; PANNUTI, Claudio S.- Plaque Reduction Neutralization Test (PRNT) in the Congenital Zika Syndrome: Positivity and Associations with Laboratory, Clinical, and Imaging Characteristics(2020) RIBEIRO, Marizelia R. C.; KHOURI, Ricardo; SOUSA, Patricia S.; BRANCO, Maria R. F. C.; BATISTA, Rosangela F. L.; COSTA, Elaine P. F.; ALVES, Maria T. S. S. B.; AMARAL, Glaucio A.; BORGES, Marcella C. R.; TAKAHASI, Eliana H. M.; GOMES, Lillian N.; MENDES, Ana K. T.; CAVALCANTE, Tamires B.; COSTA, Luciana C.; FELIX, Alvina C.; SOUZA, Nathalia C. S.; SILVA, Antonio A. M.The short duration of viremia, low blood viral load, inaccessibility to timely specific diagnostic tests, and cross-reactions with other flaviviruses have hindered laboratory confirmation of Congenital Zika Syndrome (CZS). This study analyzes the positivity of the plaque reduction neutralization test (PRNT) in children with clinical or imaging characteristics of CZS and its association with laboratory, clinical, and imaging characteristics. The 94 clinical cases of CZS submitted to the ZIKV PRNT90 test were followed from 2016 to 2018. The mean age of children at PRNT90 collection was 22 +/- 6 months Standard Deviation. The ZIKV PRNT90 was positive (titer >= 10) in 40 (42.5%) children. ZIKV PRNT90 positivity was associated with severe microcephaly in newborns (p = 0.016), lower head circumference z-score at birth (p = 0.043) and 24 months of age (p = 0.031), and severe reduction of the cerebral parenchyma volume (p = 0.021), expressing greater disease severity. Negative PRNT90 in children with characteristic signs of CZS may be due to false-negative results, indicating that the diagnosis of CZS should be primarily syndromic.