RICARDO NITRINI

(Fonte: Lattes)
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Lattes
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Departamento de Neurologia, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina

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Agora exibindo 1 - 10 de 25
  • article 0 Citação(ões) na Scopus
    The controversial Third Reich history of Hans Creutzfeldt: was he a supporter or just another adept of the ""hand washing policy""?
    (2021) CARRILHO, Paulo Eduardo Mestrinelli; NITRINI, Ricardo
    Creutzfeldt-Jakob disease (CUD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt's merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, but, in fact, he could have done more. Even during the post-war period, he sent a letter to authorities reporting the name of a Nazi physician who worked as a medical reviewer at the euthanasia court, but he did not proceed any further when his letter initially failed to start an investigation.
  • article 38 Citação(ões) na Scopus
    Evaluation of patients with Alzheimer's disease before and after dental treatment
    (2014) ROLIM, Thais de Souza; FABRI, Gisele Maria Campos; NITRINI, Ricardo; ANGHINAH, Renato; TEIXEIRA, Manoel Jacobsen; SIQUEIRA, Jose Tadeu T. de; CESARI, Jose Augusto Ferrari; SIQUEIRA, Silvia Regina Dowgan Tesseroli de
    Oral infections may play a role in Alzheimer's disease (AD). Objective: To describe the orofacial pain, dental characteristics and associated factors in patients with Alzheimer's Disease that underwent dental treatment. Method: 29 patients with mild AD diagnosed by a neurologist were included. They fulfilled the Mini Mental State Exam and Pfeffer's questionnaire. A dentist performed a complete evaluation: clinical questionnaire; research diagnostic criteria for temporomandibular disorders; McGill pain questionnaire; oral health impact profile; decayed, missing and filled teeth index; and complete periodontal investigation. The protocol was applied before and after the dental treatment. Periodontal treatments (scaling), extractions and topic nystatin were the most frequent. Results: There was a reduction in pain frequency (p=0.014), mandibular functional limitations (p=0.011) and periodontal indexes (p<0.05), and an improvement in quality of life (p=0.009) and functional impairment due to cognitive compromise (p<0.001) after the dental treatment. Orofacial complaints and intensity of pain also diminished. Conclusion: The dental treatment contributed to reduce co-morbidities associated with AD and should be routinely included in the assessment of these patients.
  • article 6 Citação(ões) na Scopus
    Codon 129 polymorphism of prion protein gene in is not a risk factor for Alzheimer's disease
    (2013) SMID, Jerusa; LANDEMBERGER, Michele Christine; BAHIA, Valeria Santoro; MARTINS, Vilma Regina; NITRINI, Ricardo
    Interaction of prion protein and amyloid-b oligomers has been demonstrated recently. Homozygosity at prion protein gene (PRNP) codon 129 is associated with higher risk for Creutzfeldt-Jakob disease. This polymorphism has been addressed as a possible risk factor in Alzheimer disease (AD). Objective:To describe the association between codon 129 polymorphisms and AD. Methods: We investigated the association of codon 129 polymorphism of PRNP in 99 AD patients and 111 controls, and the association between this polymorphism and cognitive performance. Other polymorphisms of PRNP and additive effect of apolipoprotein E gene (ApoE) were evaluated. Results: Codon 129 genotype distribution in AD 45.5% methionine (MM), 42.2% methionine valine (MV), 12.1% valine (VV); and 39.6% MM, 50.5% MV, 9.9% VV among controls (p>0.05). There were no differences of cognitive performance concerning codon 129. Stratification according to ApoE genotype did not reveal difference between groups. Conclusion: Codon 129 polymorphism is not a risk factor for AD in Brazilian patients.
  • article 0 Citação(ões) na Scopus
    Radiologic and histologic findings in Sjogren's sensory neuronopathy
    (2019) GRATIVVOL, Ronnyson Susano; CAVALCANTE, Wagner Cid Palmeira; VENTURA, Lais Maria Gomes de Brito; CALDAS, Vitor Marques; LUCATO, Leandro Tavares; LOURENCO, Silvia Vanessa; HEISE, Carlos Otto; NITRINI, Ricardo
  • article 19 Citação(ões) na Scopus
    Alzheimer's disease qEEG Spectral analysis versus coherence. Which is the best measurement?
    (2011) ANGHINAH, Renato; KANDA, Paulo Afonso Medeiros; LOPES, Helder Frederico; BASILE, Luis Fernando Hindi; MACHADO, Sergio; RIBEIRO, Pedro.; VELASQUES, Bruna; SAMESHIMA, Koichi; TAKAHASHI, Daniel Yasumasa; PINTO, Lecio Figueira; CARAMELLI, Paulo; NITRINI, Ricardo
    There is evidence in electroencephalography that alpha, theta and delta band oscillations reflect cognitive and memory performances and that quantitative techniques can improve the electroencephalogram (EEG) sensitivity. This paper presents the results of comparative analysis of qEEG variables as reliable markers for Alzheimer's disease (AD). We compared the sensitivity and specificity between spectral analysis (spectA) and coherence (Coh) within the same group of AD patients. SpectA and Coh were calculated from EEGs of 40 patients with mild to moderate AD and 40 healthy elderly controls. The peak of spectA was smaller in the AD group than in controls. AD group showed predominance of slow spectA in theta and delta bands and a significant reduction of inter-hemispheric Coh for occipital alpha 2 and beta 1 and for frontal delta sub-band. ROC curve supported that alpha band spectA was more sensitive than coherence to differentiate controls from AD.
  • article 2 Citação(ões) na Scopus
    Burden of dementia in Brazil
    (2020) NITRINI, Ricardo; FERRI, Cleusa P.
  • article 1 Citação(ões) na Scopus
    The missed missing hole
    (2012) PORTO, Fabio Henrique de Gobbi; SILVA, Mari-Nilva Maia da; DOMINGUES, Joao Roberto Sala; PORTO, Gislaine Cristina Lopes Machado; DAVAGNAMAN, Indran; NITRINI, Ricardo
    At times in clinical neurology, the identification of a subtle clinical or radiological sign can lead to prompt diagnosis of a very rare or difficult case. We report on a patient who presented with untreatable headache and unilateral ptosis. Computed tomography (CT) scan of the head did not reveal any structural cause. Magnetic resonance angiogram showed absence of left internal carotid artery, which was eventually confirmed by a catheter angiography. Reviewing the case, it emerged that a feature on the initial CT scan ""bone window"" would have confirmed the diagnosis, had it been searched for: the underdeveloped carotid canal, which is a consequence and a marker of internal carotid artery agenesis.
  • article 0 Citação(ões) na Scopus
    Current clinical and research practices on frontotemporal dementia in Brazil: a national survey
    (2023) SOUZA, Leonardo Cruz de; BRUCKI, Sonia Maria Dozzi; SCHILLING, Lucas Porcello; SILVA, Leticia Costa da; TAKADA, Leonel Tadao; BAHIA, Valeria Santoro; BARBOSA, Breno Jose Alencar Pires; BALTHAZAR, Marcio Luiz Figueredo; FROTA, Norberto Anizio Ferreira; NITRINI, Ricardo; CARAMELLI, Paulo; SMID, Jerusa
    Background Frontotemporal dementia (FTD) is a frequent cause of young-onset dementia and represents a major challenge for the diagnosis and clinical management. It is essential to evaluate the difficulties faced by physicians on the diagnostic workup and on patient care.Objective The aim of this study was to investigate the current practices and the local limits on the diagnosis and management of FTD in Brazil.Methods We elaborated an online survey, composed of 29 questions and divided in four parts, comprising questions about existing health facilities, clinical practices related to FTD, and suggestions to increment the national research on FTD. The invitation to participate was sent by email to all neurologists affiliated to the Brazilian Academy of Neurology ( n = 3658), and to all physicians who attended the XII Meeting of Researchers on Alzheimer's disease, in 2019 ( n = 187). The invitation was also diffused through social media.Results 256 Brazilian physicians answered the questionnaire. The three most relevant disorders for the differential diagnosis of FTD were Alzheimer's disease (AD) ( n = 211), bipolar disorder ( n = 117) and dementia with Lewy bodies ( n = 92). Most respondents (125/256) reported the difficulty in performing genetic testing as the main limit in the diagnostic of FTD. 93% and 63% of participants considered that the assessment of social cognition and AD CSF biomarkers are useful for the diagnosis of FTD, respectively.Conclusions The present study may provide valuable insights for the medical education and clinical training of physicians, and to foster future research on FTD in Brazil.
  • article 13 Citação(ões) na Scopus
    Brain regions supporting verbal memory improvement in healthy older subjects
    (2014) MIOTTO, Eliane C.; BALARDIN, Joana B.; SAVAGE, Cary R.; MARTIN, Maria da Graca M.; BATISTUZZO, Marcelo C.; AMARO JUNIOR, Edson; NITRINI, Ricardo
    Despite growing interest in developing cognitive training interventions to minimize the aging cognitive decline process, no studies have attempted to explore which brain regions support the application of semantic strategies during verbal memory encoding. Our aim was to investigate the behavioral performance and brain correlates of these strategies in elderly individuals using fMRI in healthy older subjects. Method: Subjects were scanned twice on the same day, before and after, directed instructions to apply semantic strategies during the encoding of word lists. Results: Improved memory performance associated to increased semantic strategy application and brain activity in the left inferior and middle and right medial superior prefrontal cortex were found after the directed instructions. There was also reduced activation in areas related to strategy mobilization. Conclusion: Improved memory performance in older subjects after the application of semantic strategies was associated with functional brain reorganization involving regions inside and outside the typical memory network.
  • article 0 Citação(ões) na Scopus
    Training of neurologists for the 21st century: cultural and professional skills
    (2022) NITRINI, Ricardo
    Background: Training of neurologists for the near future is a challenge due to the likely advances in neuroscientific methods, which will change much of our knowledge on diagnosis and treatment of neurological diseases. Objective: To comment on what may be more likely to be a constant in the very near future and to recommend how to prepare the neurologist for the 21st century. Methods: Through a critical review of recent articles on the teaching of Neurology,to present a personal view on the subject. Results: Diagnostic methods and therapeutic resources in Neurology will be greatly improved, but the central core of teaching young neurologists will continue to be the clinical/anatomical correlation. The neurologist must be prepared to be the primary physician in the care of patients with neurological disorders, although the roles of consultant and clinical neuroscientist must also be considered. In addition to technical knowledge,the neurologist must be prepared to discuss not only distressing issues related to the specialty, such as the risks of genetic diseases for family members of their patients, the inexorable progression of some diseases and the need for palliative care, but also problems not directly related to Neurology that cause anxiety and depression in the patient or that are the main reason for the initial consultation. Conclusion: Neurology will be an even more important area of medicine and the neurologist must be well prepared to be the primary doctor to diagnose, treat and follow the patient with neurological disorders. In addition to technical knowledge, training in doctor-patient relations should be highlighted.