ALEXANDRE LEME GODOY DOS SANTOS
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina
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- Posterior tibial tendinopathy associated with matrix metalloproteinase 13 promoter genotype and haplotype(2016) MUNHOZ, Francielle Bocon de Araujo; BARONEZA, Jose Eduardo; GODOY-SANTOS, Alexandre; FERNANDES, Tulio Diniz; BRANCO, Filipe Polese; ALLE, Lupe Furtado; SOUZA, Ricardo Lehtonen de; SANTOS, Maria Cristina Leme Godoy dosBackgroundPosterior tibial tendon (PTT) is particularly vulnerable and its insufficiency is recognized as the main cause of adult acquired flat foot. Some patients have a predisposition without a clinically recognized cause, suggesting that individual characteristics play an important role in tendinopathy. The present study investigated whether genetic variants in matrix metalloproteinases (MMPs) are associated with PTT dysfunction. MethodsOne hundred women who presented PTT dysfunction, with histopathological examination of the tendon and magnetic resonance imaging (MRI) confirming tendinopathy, as well as 100 asymptomatic women who presented intact PPT as assessed by MRI and constituting the control group, were evaluated for MMP-13g.-77 A>G (rs2252070) polymorphism, individually and in haplotypes, as well as in combination with MMP-1g.-519 A>G (rs1144393), MMP-1g.-1607G>GG (rs1799750) and MMP-8g.-799 C>T (rs11225395) polymorphisms with PTT dysfunction. Genomic DNA was extracted from the saliva and genotypes were obtained by polymerase chain reaction-restriction fragment length polymorphism. Statistical analysis of the results included a Mann-Whitney U-test, Fisher's exact test, multiple logistic regression, chi-squared and SNPstats software (http://bioinfo. ). p<0.05 was considered statistically significant. ResultsThe A allele frequency (MMP-13g.-77 A>G (rs2252070) polymorphism) was significantly higher in the case group (76% and 61%, respectively; p=0.010, odds ratio=2.02; 95% confidence interval=1.32-3.12). The genotype distribution was also significantly different between groups (p=0.001, odds ratio=2.82; 95% confidence interval=1.58-5.02). Global haplotype analysis indicated a significant difference between both groups. ConclusionsIn conclusion, these findings indicate that MMP-13g.-77 A>G (rs2252070) polymorphism individually, as well as its haplotypes MMP-1g.-519 A>G (rs1144393), MMP-1g.-1607G>GG (rs1799750) and MMP-8g.-799 C>T (rs11225395), may contribute to PTT dysfunction.
- Foot and ankle fractures during childhood: review of the literature and scientific evidence for appropriate treatment(2016) RAMMELT, Stefan; GODOY-SANTOS, Alexandre Leme; SCHNEIDERS, Wolfgang; FITZE, Guido; ZWIPP, HansABSTRACT Foot and ankle fractures represent 12% of all pediatric fractures. Malleolar fractures are the most frequent injuries of the lower limbs. Hindfoot and midfoot fractures are rare, but inadequate treatment for these fractures may results in compartment syndrome, three-dimensional deformities, avascular necrosis and early post-traumatic arthritis, which have a significant impact on overall foot and ankle function. Therefore, the challenges in treating these injuries in children are to achieve adequate diagnosis and precise treatment, while avoiding complications. The objective of the treatment is to restore normal anatomy and the correct articular relationship between the bones in this region. Moreover, the treatment needs to be planned according to articular involvement, lower-limb alignment, ligament stability and age. This article provides a review on this topic and presents the scientific evidence for appropriate treatment of these lesions.