ALBERTO AZOUBEL ANTUNES
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cirurgia, Faculdade de Medicina - Docente
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina - Líder
15 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 15
conferenceObject LONG-TERM EVALUATION OF TRANSURETHRAL INCISION OF THE PROSTATE FOR TREATMENT OF BENIGN PROSTATE HYPERPLASIA: ANALYSIS OF 75 CASES WITH A MEAN 8-YEAR FOLLOW-UP PERIOD(2015) CORDEIRO, Paulo; BARONE, Hugo; YOSHINAGA, Eduardo Muracca; NAKANO, Elcio; NAHAS, William C.; SROUGI, Miguel; ANTUNES, Alberto A.conferenceObject LOW-VOLUME PROSTATE IN BENIGN PROSTATIC HYPERPLASIA (BPH): A RISK FACTOR FOR SYMPTOMATIC BLADDER DIVERTICULA REQUIRING SURGICAL TREATMENT(2015) YOSHINAGA, Eduardo Muracca; NAKANO, Elcio; MARCHINI, Giovanni S.; OYAMA, Renato Hajime; CORDEIRO, Paulo; NAHAS, William C.; SROUGI, Miguel; ANTUNES, Alberto A.- Analysis of the learning curve for transurethral resection of the prostate. Is there any influence of musical instrument and video game skills on surgical performance?(2015) YAMACAKE, Kleiton Gabriel Ribeiro; NAKANO, Elcio Tadashi; SOARES, Iva Barbosa; CORDEIRO, Paulo; SROUGI, Miguel; ANTUNES, Alberto AzoubelObjective: To evaluate the learning curve for transurethral resection of the prostate (TURP) among urology residents and study the impact of video game and musical instrument playing abilities on its performance. Material and methods: A prospective study was performed from July 2009 to January 2013 with patients submitted to TURP for benign prostatic hyperplasia. Fourteen residents operated on 324 patients. The following parameters were analyzed: age, prostate-specific antigen levels, prostate weight on ultrasound, pre- and postoperative serum sodium and hemoglobin levels, weight of resected tissue, operation time, speed of resection, and incidence of capsular lesions. Gender, handedness, and prior musical instrument and video game playing experience were recorded using survey responses. Results: The mean resection speed in the first 10 procedures was 0.36 g/min and reached a mean of 0.51 g/min after the 20th procedure. The incidence of capsular lesions decreased progressively. The operation time decreased progressively for each subgroup regardless of the difference in the weight of tissue resected. Those experienced in playing video games presented superior resection speed (0.45 g/min) when compared with the novice (0.35 g/min) and intermediate (0.38 g/min) groups (p=0.112). Musical instrument playing abilities did not affect the surgical performance. Conclusion: Speed of resection, weight of resected tissue, and percentage of resected tissue improve significantly and the incidence of capsular lesions reduces after the performance of 10 TURP procedures. Experience in playing video games or musical instruments does not have a significant effect on outcomes.
conferenceObject CAN WE PREDICT WHICH PATIENTS WILL PRESENT RESOLUTION OF DETRUSOROVERACTIVITY (DO) AFTER TRANSURETHRAL RESECTION OF THE PROSTATE (TURP)?(2015) ISCAIFE, Alexandre; REIS, Sabrina T.; ALBERTINI, Aline; NUNES, Marco A.; LUCON, Antonio M.; NAHAS, Willian C.; SROUGI, Miguel; ANTUNES, Alberto A.- Loss of TIMP-1 immune expression and tumor recurrence in localized prostate cancer(2015) REIS, Sabrina Thalita dos; VIANA, Nayara Izabel; ISCAIFE, Alexandre; PONTES-JUNIOR, Jose; DIP, Nelson; ANTUNES, Alberto Azoubel; GUIMARAES, Vanessa Ribeiro; SANTANA, Isaque; NAHAS, William Carlos; SROUGI, Miguel; LEITE, Katia Ramos MoreiraIntroduction and objective: Overexpression of MMPs has been related to biochemical recurrence after radical prostatectomy. TIMP1 and TIMP2 are controllers of MMPs and the aim of this study is to evaluate the expression levels of MMPs and their regulators using immunohistochemistry in tissue microarray of localized prostate cancer (PC). Materials and Methods: Immune-expression of MMP-9, MMP-2, TIMP1, TIMP-2, MMP-14 and IL8, were analyzed by immunohistochemistry in radical prostatectomy specimens of 40 patients with localized PC who underwent surgery between September 1997 and February 2000. Protein expression was considered as categorical variables, negative or positive. The results of the immune-expression were correlated to Gleason score (GS), pathological stage (TNM), pre-operatory PSA serum levels and biochemical recurrence in a mean follow up period of 92.5 months. Results: The loss of TIMP1 immune-expression was related to biochemical recurrence. When TIMP1 was negative, 56.3% patients recurred versus 22.2% of those whose TIMP1 was positive (p=0.042). MMP-9, MMP-2, IL8 and MMP-14 were positive in the majority of PC. TIMP-2 was negative in all cases. Conclusion: Negative immune-expression of TIMP1 is correlated with biochemical recurrence in patients with PC possibly by failing to control MMP-9, an important MMP related to cancer progression.
conferenceObject ROLE OF PHYSICAL ACTIVITY IN THE PREVENTION OF BPH THROUGH INHIBITION OF PROSTATIC IGF1/AKT PROLIFERATIVE AXIS: AN EXPERIMENTAL STUDY IN RATS.(2015) FONSECA, Fernando Froes; OLIVEIRA, Andre M.; REIS, Sabrina T.; LEITE, Katia R.; NAHAS, William C.; SROUGI, Miguel; ANTUNES, Alberto A.- COMO AVALIAR PRODUÇÃO CIENTÍFICA(2015) ANTUNES, Alberto AzoubelObjective: To conduct a critical analysis of the two main bibliometric indexes used by science: the impact factor and the H index. Method: Research was conducted on PubMed using the keywords: impact factor, Bibliometrics and H index. Results: The citations of articles tend to follow a curve in which the articles published in a given year increase sharply to a peak occurring between two and six years after its publication. From this peak citations decline over time. Conclusion: The analysis of the scientific merit should not be based on only in bibliometric measure, but in the association of various parameters. The impact factor and the H index is mainly based on the number of citations of scientific papers, and this parameter, although important, should not be used alone, nor overvalued in the evaluation of teaching merit.
- Prostatic Artery Embolization for Treatment of Benign Prostatic Hyperplasia in Patients with Prostates > 90 g: A Prospective Single-Center Study(2015) ASSIS, Andre Moreira de; MOREIRA, Airton Mota; RODRIGUES, Vanessa Cristina de Paula; YOSHINAGA, Eduardo Muracca; ANTUNES, Alberto Azoubel; HARWARD, Sardis Honoria; SROUGI, Miguel; CARNEVALE, Francisco CesarPurpose: To describe the safety and efficacy of prostatic artery embolization (PAE) with spherical microparticles to treat lower urinary tract symptoms associated with benign prostatic hyperplasia in patients with prostate volume > 90 g. Materials and Methods: This prospective, single-center, single-arm study was conducted in 35 patients with prostate volumes ranging from 90-252 g. Mean patient age was 64.8 years (range, 53-77 y). Magnetic resonance imaging, uroflowmetry, and the International Prostate Symptom Score (IPSS) were used to assess clinical and functional outcomes. Results: Mean prostate size decreased significantly from 135.1 g before PAE to 91.9 g at 3 months of follow-up (P < .0001). Mean IPSS and quality-of-life index improved from 18.3 to 2.7 and 4.8 to 0.9 (P < .0001 for both), respectively. A significant negative conelation was observed between prostate-specific antigen at 24 hours after PAE and IPSS 3 months after PAE (P = .0057). Conclusions: PAE is a safe and effective treatment for lower urinary tract symptoms secondary to benign prostatic hyperplasia in patients with prostate volume > 90 g. Excessively elevated prostate-specific antigen within 24 hours of PAE is associated with; lower symptom burden in short-term follow-up.
- COMO CHEGAR E MANTER A NOTA 6?(2015) ANTUNES, Alberto AzoubelObjective: To describe the main measures adopted in order to raise the concept of USP Urology program, and thus be able to help other programs with similar shortcomings to remedy these problems. Method: We highlighted the measures taken between the years 2005 and 2013 which contributed to the CAPES elevation of the Postgraduate Program of the USP Urology concept. Results: It was created new disciplines focused on researchers and teachers training rather than clinical aspects. Specific research areas have been created for each permanent teacher, and the theses and dissertations became linked research lines. The entire student body and faculty not interested or who had performance below the average was off the program. Was encouraged fundraising culture into program. It was also highlighted the creation of online medical record, where the clinical data of all patients treated at the Urology Division were stored. Conclusion: Rigorous selection of motivated faculty and students, able to create adequate infrastructure and achieving financial resources, is of fundamental importance for the consolidation of a postgraduate program.
- Can We Predict Which Patients will Experience Resolution of Detrusor Overactivity after Transurethral Resection of the Prostate?(2015) ANTUNES, Alberto Azoubel; ISCAIFE, Alexandre; REIS, Sabrina Thalita; ALBERTINI, Aline; NUNES, Marco Antonio; LUCON, Antonio Marmo; NAHAS, William Carlos; SROUGI, MiguelPurpose: We determined which clinical and urodynamic variables may be related to persistent detrusor overactivity after transurethral resection of the prostate. Materials and Methods: We studied 46 patients with bladder outlet obstruction due to benign prostatic hyperplasia who were treated with transurethral prostate resection from 2011 to 2012. All patients underwent urodynamic analysis preoperatively and 12 months postoperatively. Clinical and urodynamic variables in the preoperative period were correlated with the resolution of detrusor overactivity postoperatively. Results: Patients with detrusor overactivity in the preoperative period were older (65.2 vs 61.1 years, p = 0.041) and had a higher I-PSS (International Prostate Symptom Score) (25.2 vs 19, p = 0.014) and higher maximum flow rate (8.6 vs 6.6 ml per second, p = 0.039). Patients with persistent detrusor overactivity were statistically older than those with resolution (69 vs 63 years, p = 0.043). Detrusor overactivity persisted in 63.6% of patients with maximum cystometric capacity less than 250 ml compared to 20% of those with greater than 250 ml (p = 0.024). When analyzing urodynamic variables together, we found a 66.7% chance of persistent detrusor overactivity in patients with maximum cystometric capacity less than 250 ml and detrusor overactivity amplitude greater than 40 cm H2O (p = 0.041). When these characteristics were associated with early detrusor overactivity, the chance of persistent detrusor overactivity was 83.3% (p = 0.013). Conclusions: Advanced patient age together with low maximum cystometric capacity, and early and high detrusor overactivity amplitude are the most important predictors of persistent detrusor overactivity after relief of bladder outlet obstruction.