CRISTINA MARIA KOKRON
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
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- Association between immunologic parameters, glycemic control, and postextraction complications in patients with type 2 diabetes(2015) FERNANDES, Karin Sa; GLICK, Michael; SOUZA, Mario Sergio de; KOKRON, Cristina Maria; GALLOTTINI, MarinaBackground. The purpose of this study was to assess the association between metabolic control and immune dysfunction, and postoperative complications and wound healing after dental extractions in people with type 2 diabetes and control participants. Methods. The authors performed a prospective, case-control study enrolling 53 participants with type 2 diabetes and 29 participants who did not have type 2 diabetes. Exclusion criteria included being a smoker and having teeth with periodontal pockets deeper than 4 millimeters, among others. All participants underwent an extraction of 1 erupted tooth. The investigators assessed patients' signs and symptoms at 3, 7, 21, and 60 days after surgery. The investigators measured glycemic control and immunologic profile at the time of the extraction. They compared the pattern of healing and the incidence of post-extraction complications between the 2 groups. Results. Even in the presence of impaired neutrophil function and poor glycemic control, we found no increase in the number of postoperative complications. There was no association between delayed wound epithelialization on postoperative day 21 and level of glycemic control, and reduced neutrophil function. On postoperative day 60, all alveolar sockets were epithelialized completely and showed no signs of infection. Conclusions. The study results suggest that type 2 diabetes per se or glycemic control is not a risk factor for experiencing postoperative complications in people undergoing dental extractions. Although people with type 2 diabetes may have impaired neutrophil function, the study results revealed that having this condition was not associated with an increased risk of experiencing postoperative complications. Additional research studies with larger sample sizes of patients who have diabetes are needed to confirm this study's findings. Practical Implications. The results allow clinicians to infer that people with type 2 diabetes undergoing dental extractions of erupted teeth that do not have an acute odontogenic infection should not receive antibiotic prophylaxis simply because of their diabetic status or level of glycemic control.
- Ataxia-Telangiectasia: Epidemiological Survey in Latin America(2019) DANTAS, Ellen Oliveira; LOEKMANWIDJAJA, Jessica; MAZZUCCHELLI, Juliana Themudo Lessa; ARANDA, Carolina S.; SERRANO, Maria Edith Gonzalez; BEZRODNIK, Liliana; MOREIRA, Ileana; FERREIRA, Janaira Fernandes Severo; DANTAS, Vera M.; SALES, Valeria Soraya de Farias; SR., Carmen C. Fernandez; VILELA, Maria Marluce dos Santos; MOTA, Isabella Prado; FRANCO, Jose; ORELLANA, Julio C.; KOKRON, Cristina M.; REGAIRAZ, Lorena; CABANILLAS, Diana; BARROS, Myrthes T.; SUAREZ, Carmen L. Navarrete; ROSARIO, Nelson Augusto; CHONG NETO, Herberto J.; TAKANO, Olga Akiko; NADAF, Maria Isabel Santos Valdomir; MORAES, Lillian S. L.; TAVARES, Fabiola Scancetti; RABELLO, Flaviane; PINO, Jessica; CALDERON, Wilmer Cordova; QUISPE, Daniel Enrique Mendonza; GOUDOURIS, Ekaterine S.; PATINO, Virginia; MONTENEGRO, Cecilia; SOUZA, Monica; BRANCO, Aniela Castelo; CONDINO-NETO, Antonio; FORTE, Wilma Carvalho Neves; CARVALHO, Flavia Amendola Anisio; SEGUNDO, Gesmar; CHEIK, Marina Fernandes Almeida; JUNIOR, Persio R.; PERES, Maryanna; OLIVEIRA, Annie Mafra; PORTO NETO, Arnaldo Carlos; LOPEZ, Maria Claudia Ortega; ALOZANO, Alejandro; ALOZANO, Natalia; HERNANDEZ, Leticia; GRUMACH, Anete S.; COSTA, Daniele Comin; ANTUNES, Nelma Maria Neves; NUDELMAN, Victor; PEREIRA, Camila Teles Machado; MARTINEZ, Maria Dolores Mogica; QUIROZ, Francisco Javier Rodriguez; CARDONA, Aristoteles Alvarez; NUNEZ, Maria Enriqueta; RODRIGUEZ, Jairo Antonio; CUELLAR, Celia Martinez; VIJODITZ, Gustavo; BICHUETTI-SILVA, Danielli Christinni; PRANDO, Carolina C. M.; COSTA-CARVALHO, Beatriz Tavares
- Inversion of the V delta 1 to V delta 2 gamma delta T cell ratio in CVID is not restored by IVIg and is associated with immune activation and exhaustion(2016) PAQUIN-PROULX, Dominic; BARSOTTI, Nathalia Silveira; SANTOS, Bianca A. N.; MARINHO, Ana Karolina B. B.; KOKRON, Cristina M.; CARVALHO, Karina I.; BARROS, Myrthes T.; KALIL, Jorge; NIXON, Douglas F.; KALLAS, Esper G.Common variable immunodeficiency (CVID) is defined by low levels of IgG and IgA, but perturbations in T cells are also commonly found. However, there is limited information on gamma delta T cells in CVID patients. Newly diagnosed CVID patients (n=15) were enrolled before and after intravenous IgG (IVIg) replacement therapy. Cryopreserved peripheral blood mononuclear cells were then used to study gamma delta T cells and CVID patients were compared to healthy controls (n=22). The frequency and absolute count of V delta 1 gamma delta T cells was found to be increased in CVID (median 0.60% vs 2.64%, P<0.01 and 7.5 vs 39, P<0.01 respectively), while they were decreased for V delta 2 gamma delta T cells (median, 2.36% vs 0.74%, P<0.01 and 37.8 vs 13.9, P<0.01 respectively) resulting in an inversion of the V delta 1 to V delta 2 ratio (0.24 vs 1.4, P<0.001). Markers of immune activation were elevated on all subsets of gamma delta T cells, and HLA-DR expression was associated with an expansion of V delta 1 gamma delta T cells (r=0.73, P=0.003). Elevated PD-1 expression was found only on V delta 2 gamma delta T cells (median 1.15% vs 3.08%, P<0.001) and was associated with the decrease of V delta 2 gamma delta T cells (r=-0.67, P=0.007). IVIg had no effect on the frequency of V delta 1 and V delta 2 gamma delta T cells or HLA-DR expression, but alleviated CD38 expression on V delta 1 gamma delta T cells (median MFI 965 vs 736, P<0.05). These findings suggest that immunological perturbations of gamma delta T cells are a general feature associated with CVID and are only partially reversed by IVIg therapy.