CRISTINA MARIA KOKRON
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
conferenceObject Circulating Immature B Lymphocytes and Chronic ER Stress in CVID Patients(2012) ROSA, Susana E. A.; KOKRON, Cristina M.; CAMARGO, Maristela M. deSome CVID patients present large immature-looking B lymphocytes in the peripheral blood. Differentiation stages of B cells were qualified by multiparametric FCM and markers CD5, CD19, CD23, CD38, CD45, and FMC7. The analysis of 16 patients and 9 healthy donors revealed that all donors and 13 CVID patients had normal counts of prototypical mature B cells. However, 3 patients had increased numbers of immature and decreased numbers of mature B cells. Those immature cells were earlier stages normally restricted to lymphoid tissues. Analysis of the Unfolded Protein Response (UPR) revealed that B cells from one of these patients presented chronic ER stress, suggesting an inability to deal with physiological demands for protein folding. We identified a sub-group of CVID patients whose circulating immature B cells might be unable to produce Igs due to their immature state. The chronic ER stress found in one these patients interferes with the cell’s maturation program and lead to early apoptosis.- Oral manifestations in patients with hypogammaglobulinemia(2012) FERNANDES, Karin Sa; KOKRON, Cristina Maria; BARROS, Myrthes Toledo; KALIL, Jorge; GALLOTTINI, MarinaObjective. The overall objective of this study was to assess the oral manifestations and their association with immunologic status and health history, of individuals with hypogammaglobulinemia. Study Design. A case-controlled study of 100 subjects with hypogammaglobulinemia and 93 control individuals was performed. All participants were examined for dental caries, periodontal disease, mucosal lesions/infections, and general oral health problems. Decayed, missing, filled teeth and community periodontal index were recorded. Complete blood count, serum immunoglobulins, and lymphocyte immunophenotyping were measured on the same day of the oral health assessment. Results. Individuals with hypogammaglobulinemia showed higher prevalence of enamel hypoplasia and complaints of dry mouth, and lower prevalence of dental caries and periodontal disease. Conclusions. The systemic conditions associated with hypogammaglobulinemia were not associated with enhanced susceptibility to caries, gingivitis, or periodontitis; however, individuals with hypogammaglobulinemia were more likely to report more episodes of recurrent aphthous ulcers compared with control individuals. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:e19-e24)
conferenceObject Evaluation of Clinical and Laboratory Response to Influenza and H1N1 Vaccines in a Group of Brazilian CVID Patients(2012) PEDRESCHI, Maira; OLIVEIRA, Ana Karolina Barreto; BARROS, Myrthes Toledo; COHON, Andrea; CELESTINO, A. T.; VILAS-BOAS, L. S.; FELIX, A. C.; PANNUTI, C. S.; KALIL, Jorge; KOKRON, Cristina M.CVID pts lack vaccine-specific ab production. We studied the clinical / laboratorial responses to influenza and H1N1 immunization in 22 CVID pts. Clinical evaluation was done through a score (infections, hospitalizations, antibiotic use). The score was applied during the previous and following year post immunization (PI). Blood was drawn before and 1/3/6/12 m PI. A significant reduction was observed in upper respiratory infections and sinusitis in the year PI (p<0.001), and 6 pts seroconverted. Statistical analysis showed no difference among ab levels before and PI. Among the 9 pts who presented H1N1 ab production, 4 reduced the clinical score. Of note, 50% of the 22 pts presented reduction of clinical scores. Then, although ab production to H1N1 wasn’t statistically significant, we observed a reduction in the number of infections in the year PI. This observation may be due to eventual presence of influenza’sabs but reinforces potential benefits of vaccination in CVID pts.