VICENTE ODONE FILHO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Pediatria, Faculdade de Medicina - Docente
Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/36 - Laboratório de Pediatria Clínica, Hospital das Clínicas, Faculdade de Medicina - Líder
Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/36 - Laboratório de Pediatria Clínica, Hospital das Clínicas, Faculdade de Medicina - Líder
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conferenceObject Comparing Colonization Surveillance Results in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation That Developed Bloodstream Infection(2019) TUSANI, G.; PERON, K.; OGUITA, S.; SUNAKOZAWA, O.; KAWAI, L.; MARRI, S.; LACERDA, J.; MACEDO, L.; BERBER, S.; BENEDITO, A.; FILHO, V.conferenceObject Height Deficit in Brazilian Children and Adolescents with Acute Lymphoblastic Leukaemia at Diagnosis: Impact on Overall Survival(2019) VIANI, K.; MANZOLI, B.; BOUCHABKI, G.; NETO, M.; OLIVEIRA, V.; CRISTOFANI, L.; ODONE FILHO, V.- Rituximab desensitization protocol in a child with secondary lymphoproliferative disease(2019) ARANDA, Carolina S.; ENSINA, Luis Felipe; MALLOZI, Marcia C.; ODONE FILHO, Vicente; SOLE, Dirceu
- Atypical presentation of a germline APC mutation in a child with supratentorial primitive neuroectodermal tumor(2019) AGUIAR, Talita Ferreira; BARBOSA-TEIXEIRA, Anne C.; COSTA, Silvia Souza; EZQUINA, Suzana; GIMENEZ, Thamiris Magalhaes; NOVAK, Estela; CRISTOFANI, Lilian Maria; ROSENBERG, Carla; ODONE FILHO, Vicente; KREPISCHI, Ana Cristina Victorino
- Mandibular radiomorphometric assessment of bone mineral density in survivors of pediatric hematopoietic stem-cell transplantation(2019) FRASCINO, Alexandre Viana; COSTA, Claudio; SALGADO, Daniela Miranda Richarte de Andrade; CORACIN, Fabio Luiz; FAVA, Marcelo; ODONE-FILHO, VicenteOBJECTIVE: Hematopoietic stem-cell transplantation (HSCT) childhood survivors of hematologic malignancies are prone to develop late osteopenia and osteoporosis. The purpose of this retrospective study was to quantitatively and qualitatively assess bone mineral density (BMD) in HSCT childhood survivors and to compare the effectiveness of both qualitative and quantitative assessment methods. METHODS: DESIGN BMD assessment using panoramic radiographs of childhood HSCT survivors aged 3.69-18.88 years using two radiomorphometric indexes. Case-control double-blinded comparison of panoramic radiographic images from childhood HSCT survivors and age-and sex-matched healthy controls. Quantitative assessment was performed by measuring the cortical bone width bilaterally at the mental foramen level. Qualitative assessment was performed using the mandibular cortical index bilaterally on all panoramic images. RESULTS: Radiographs were taken 6.59-83.95 months after bone marrow transplantation [median +/- SD=25.92 +/- 24.9 months]. Fifty-two panoramic radiographic images were analyzed: 21 from HSCT survivors and 31 from healthy controls aged 3.69-25.1 years [mean +/- SD=11.89 +/- 5.28 years]. The mandibular cortical bone width was 17% smaller in childhood HSCT survivors than in healthy controls (case group: 2.420, control group: 3.307; p=0.00617). Qualitative analysis revealed an increased frequency of severe mandibular cortical erosion in childhood HSCT survivors, although no significant difference was observed (case group: 1.540, control group: 1.490; p=0.32). The interobserver agreement was 85% (Kappa index). CONCLUSIONS: HSCT childhood survivors exhibit quantitative and qualitative mandibular bone impairments. Further studies are needed to establish an association between mandibular cortical bone impairment and osteoporosis.
- Long-Term Evaluation of Post-transplant Lymphoproliferative Disorders in Paediatric Heart Transplantation in Sao Paulo, Brazil(2019) ARSHAD, Adam; AZEKA, Estela; BARBAR, Samia; MARCONDES, Raphael; SIQUEIRA, Adailson; BENVENUTI, Luiz; MIURA, Nana; JATENE, Marcelo; ODONE FILHO, VicenteWe sought to better define the demographics and characteristics of post-transplant lymphoproliferative disorders (PTLD) in a cohort of paediatric OHT patients from a developing country. Data were collected from the Heart Institute, Sao Paulo, for all paediatric OHT recipients from October 1992 to October 2018. Group differences between the PTLD and non-PTLD cohorts were assessed by Fisher exact and Mann-Whitney U tests. Kaplan-Meier curves analysed the survival in each group. Data were reviewed for 202 paediatric OHT recipients. Overall 1-, 5- and 10-year survival for the entire cohort was 76.5%, 68.3% and 62.9%; 24 patients (11.9%) developed PTLD at a median 3.1 years (IQR 0.8-9.0) after OHT. Cases were evenly spread over the follow-up period, with PTLD diagnosed in 9.8% (n = 137) of patients who were alive at 3 years, 15.3% (n = 78) of patients who were alive at 5 years and 29.3% (n = 41) of patients who were alive at 10 years. The commonest form of PTLD was diffuse large B cell lymphoma (n = 9), and most patients received rituximab with immunosuppression and chemotherapy as treatment (n = 15). We identified no increased risk in mortality amongst the PTLD vs. non-PTLD cohorts in multivariate analysis (P = 0.365). PTLD after paediatric OHT had acceptable outcomes. However, risk factors for PTLD were not identified and warrant further investigation.
- Mortality in adolescents and young adults with chronic diseases during 16 years: a study in a Latin American tertiary hospital(2019) RAMOS, Gabriel F.; RIBEIRO, Vanessa P.; MERCADANTE, Mariana P.; RIBEIRO, Maira P.; DELGADO, Artur F.; FARHAT, Sylvia C. L.; LEAL, Marta M.; MARQUES, Heloisa H.; ODONE-FILHO, Vicente; TANNURI, Uenis; CARVALHO, Werther B.; GRISI, Sandra J.; CARNEIRO-SAMPAIO, Magda; SILVA, Clovis A.Objectives: To evaluate mortality in adolescents and young adult patients with chronic diseases followed in a Latin American tertiary hospital. Methods: A cross-sectional retrospective study was performed in a tertiary/academic hospital in the state of Sao Paulo, Brazil. Death occurred in 529/2850 (18.5%) adolescents and young adult patients with chronic diseases, and 25/529 (4.7%) were excluded due to incomplete medical charts. Therefore, 504 deaths were evaluated. Results: Deaths occurred in 316/504 (63%) of early adolescent patients and in 188/504 (37%) of late adolescent/young adult patients. Further comparisons between early adolescents (n=316) and late adolescent/young adult patients (n= 188) with pediatric chronic diseases at the last hospitalization showed that the median disease duration (22.0 [0-173] vs. 43.0 [0-227] months, p < 0.001) was significantly lower in early adolescents vs. late adolescent/young adult patients. The median number of previous hospitalizations was significantly lower in the former group (4.0 [1-45] vs. 6.0 [1-52], p < 0.001), whereas the last hospitalization in intensive care unit was significantly higher (60% vs. 47%, p= 0.003). Regarding supportive measures, palliative care was significantly lower in the younger group compared to the older group (33% vs. 43%, p= 0.02). The frequencies of renal replacement therapy (22% vs. 13%, p = 0.02), vasoactive agents (65% vs. 54%, p= 0.01), and transfusion of blood products (75% vs. 66%, p = 0.03) were significantly higher in the younger group. The five most important etiologies of pediatric chronic diseases were: neoplasias (54.2%), hepatic diseases/transplantation (10%), human immunodeficiency virus (5.9%), and childhood-onset systemic lupus erythematosus and juvenile idiopathic arthritis (4.9%). Autopsy was performed in 58/504 (11%), and discordance between clinical and postmortem diagnoses was evidenced in 24/58 (41.3%). Conclusions: Almost 20% of deaths occurred in adolescents and young adults with distinct supportive care and severe disease patterns. Discordance between clinical diagnosis and autopsy was frequently observed. (C) 2018 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Pediatria.