KATIA RAMOS MOREIRA LEITE

(Fonte: Lattes)
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Departamento de Cirurgia, Faculdade de Medicina - Docente
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/26 - Laboratório de Pesquisa em Cirurgia Experimental, Hospital das Clínicas, Faculdade de Medicina

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Assunto: Pathology ×

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Agora exibindo 1 - 10 de 39
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    GLUT1 Expression Is Related to Tumor Recurrence and Survival in Renal Cell Carcinoma Clear Cell Type
    (2017) LEITE, Katia R. M.; CARVALHO, Paulo A.; PINHEIRO, Celine M.; REIS, Sabrina T.; SROUGI, Miguel; NAHAS, William C.
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    GLUT1 Expression Is Related to Tumor Recurrence and Survival in Renal Cell Carcinoma Clear Cell Type
    (2017) LEITE, Katia R. M.; CARVALHO, Paulo A.; PINHEIRO, Celme M.; REIS, Sabrina T.; SROUGI, Miguel; NAHAS, William C.
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    Validation of a New Methanol Based Fixative for Cervical Cytology
    (2017) LEITE, Katia R. M.; SILVA, Thais; NAUM, Bruno; CANAVEZ, Flavio C.; CANAVEZ, Juliana M. S.; CAMARA-LOPES, Luiz Heraldo A.
  • article 36 Citação(ões) na Scopus
    Utility of Pathology Imagebase for standardisation of prostate cancer grading
    (2018) EGEVAD, Lars; DELAHUNT, Brett; BERNEY, Daniel M.; BOSTWICK, David G.; CHEVILLE, John; COMPERAT, Eva; EVANS, Andrew J.; FINE, Samson W.; GRIGNON, David J.; HUMPHREY, Peter A.; HORNBLAD, Jonas; ICZKOWSKI, Kenneth A.; KENCH, James G.; KRISTIANSEN, Glen; LEITE, Katia R. M.; MAGI-GALLUZZI, Cristina; MCKENNEY, Jesse K.; OXLEY, Jon; PAN, Chin-Chen; SAMARATUNGA, Hemamali; SRIGLEY, John R.; TAKAHASHI, Hiroyuki; TRUE, Lawrence D.; TSUZUKI, Toyonori; KWAST, Theo van der; VARMA, Murali; ZHOU, Ming; CLEMENTS, Mark
    AimsDespite efforts to standardise grading of prostate cancer, even among experts there is still a considerable variation in grading practices. In this study we describe the use of Pathology Imagebase, a novel reference image library, for setting an international standard in prostate cancer grading. Methods and resultsThe International Society of Urological Pathology (ISUP) recently launched a reference image database supervised by experts. A panel of 24 international experts in prostate pathology reviewed independently microphotographs of 90 cases of prostate needle biopsies with cancer. A linear weighted kappa of 0.67 (95% confidence interval = 0.62-0.72) and consensus was reached in 50 cases. The interobserver weighted kappa varied from 0.48 to 0.89. The highest level of agreement was seen for Gleason score (GS) 3 + 3 = 6 (ISUP grade 1), while higher grades and particularly GS 4 + 3 = 7 (ISUP grade 3) showed considerable disagreement. Once a two-thirds majority was reached, images were moved automatically into a public database available for all ISUP members at . Non-members are able to access a limited number of cases. ConclusionsIt is anticipated that the database will assist pathologists to calibrate their grading and, hence, decrease interobserver variability. It will also help to identify instantces where definitions of grades need to be clarified.
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    Micro RNA 100, 145 and 373 in prostate cancer: From gene regulation to apoptosis
    (2014) ISCAIFE, A.; MORAIS, D. R.; REIS, S. T.; VIANA, N. I.; KATZ, B.; MOURA, C.; DIP, N.; SROUGI, M.; LEITE, K. R. Moreira
  • article 3 Citação(ões) na Scopus
    Influence of a hypercholesterolemic diet on the collagen composition of the bladder wall extracellular matrix in rats
    (2012) NUNES, R. L. V.; BRUSCHINI, H.; UTSUNOMIA, K.; SILVEIRA, M. A.; TEODORO, W. R.; LEITE, K. R. M.; SROUGI, M.
    Purpose: To investigate the effects of hypercholesterolemic diet on the collagen composition of urinary bladder wall. Materials and methods: Forty-five female 4-week-old Wistar rats were divided into three groups: 1) control group fed a normal diet (ND); 2) model of bladder outlet obstruction (BOO) group fed a ND; and 3) group fed a HCD (1.25% cholesterol). Total serum cholesterol, LDL cholesterol and body weight were assessed at baseline. Four weeks later, group 2 underwent a surgical procedure resulting in a partial BOO, while groups 1 and 3 underwent a sham similar surgical procedure. Six weeks later, all animals had their bladders removed; serum cholesterol and LDL cholesterol levels and body weights were measured. Morphological and morphometric analysis was performed by Picrosirius staining and collagen types I and III were identified by immunofluorescence. Statistical analysis was completed and significance was considered when p<0.05. Results: Rats fed an HCD exhibited a significant increase in LDL cholesterol levels (p<0.001) and body weight (p=0.017), when compared to the groups fed a ND during the ten-week study period. Moreover, the HCD induced morphological alterations of the bladder wall collagen, regarding thin collagen fibers and the amounts of type III collagen when compared to the control group (p=0.002 and p=0.016, respectively), resembling the process promoted in the BOO model. Conclusions: A hyper-cholesterolemic diet in Wistar rats promoted morphological changes of the bladder types of collagen, as well as increases in body weight and LDL cholesterol.
  • article 0 Citação(ões) na Scopus
    Brazilian Expert Consensus for NTRK Gene Fusion Testing in Solid Tumors
    (2023) MACEDO, Mariana Petaccia de; NASCIMENTO, Ellen Caroline Toledo; SOARES, Fernando Augusto; SANTINI, Fernando Costa; COSTA, Felipe D'Almeida; CUNHA, Isabela Werneck da; MUNHOZ, Rodrigo Ramella; MARCHI, Pedro De; JORGE, Thiago William Carnier; LEITE, Katia Ramos Moreira
    Oncogenic neurotrophic tropomyosin receptor kinase gene fusions occur in less than 1% of common cancers. These mutations have emerged as new biomarkers in cancer genomic profiling with the approval of selective drugs against tropomyosin receptor kinase fusion proteins. Nevertheless, the optimal pathways and diagnostic platforms for this biomarker's screening and genomic profiling have not been defined and remain a subject of debate. A panel of national experts in molecular cancer diagnosis and treatment was convened by videoconference and suggested topics to be addressed in the literature review. The authors proposed a testing algorithm for oncogenic neurotrophic tropomyosin receptor kinase gene fusion screening and diagnosis for the Brazilian health system. This review aims to discuss the latest literature evidence and international consensus on neurotrophic tropomyosin receptor kinase gene fusion diagnosis to devise clinical guidelines for testing this biomarker. We propose an algorithm in which testing for this biomarker should be requested to diagnose advanced metastatic tumors without known driver mutations. In this strategy, Immunohistochemistry should be used as a screening test followed by confirmatory next-generation sequencing in immunohistochemistry-positive cases.
  • article 2 Citação(ões) na Scopus
    Interobserver reproducibility of cribriform cancer in prostate needle biopsies and validation of International Society of Urological Pathology criteria
    (2023) EGEVAD, Lars; DELAHUNT, Brett; ICZKOWSKI, Kenneth A.; KWAST, Theo van der; LEENDERS, Geert J. L. H. van; LEITE, Katia R. M.; PAN, Chin-Chen; SAMARATUNGA, Hemamali; TSUZUKI, Toyonori; MULLIQI, Nita; JI, Xiaoyi; OLSSON, Henrik; VALKONEN, Masi; RUUSUVUORI, Pekka; EKLUND, Martin; KARTASALO, Kimmo
    AimsThere is strong evidence that cribriform morphology indicates a worse prognosis of prostatic adenocarcinoma. Our aim was to investigate its interobserver reproducibility in prostate needle biopsies. Methods and resultsA panel of nine prostate pathology experts from five continents independently reviewed 304 digitised biopsies for cribriform cancer according to recent International Society of Urological Pathology criteria. The biopsies were collected from a series of 702 biopsies that were reviewed by one of the panellists for enrichment of high-grade cancer and potentially cribriform structures. A 2/3 consensus diagnosis of cribriform and noncribriform cancer was reached in 90% (272/304) of the biopsies with a mean kappa value of 0.56 (95% confidence interval 0.52-0.61). The prevalence of consensus cribriform cancers was estimated to 4%, 12%, 21%, and 20% of Gleason scores 7 (3 + 4), 7 (4 + 3), 8, and 9-10, respectively. More than two cribriform structures per level or a largest cribriform mass with >= 9 lumina or a diameter of >= 0.5 mm predicted a consensus diagnosis of cribriform cancer in 88% (70/80), 84% (87/103), and 90% (56/62), respectively, and noncribriform cancer in 3% (2/80), 5% (5/103), and 2% (1/62), respectively (all P < 0.01). ConclusionCribriform prostate cancer was seen in a minority of needle biopsies with high-grade cancer. Stringent diagnostic criteria enabled the identification of cribriform patterns and the generation of a large set of consensus cases for standardisation.