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Assunto: Cardiac & Cardiovascular Systems ×

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  • article 8 Citação(ões) na Scopus
    O escore de risco de sangramento como preditor de mortalidade em pacientes com síndromes coronarianas agudas
    (2013) NICOLAU, José Carlos; MOREIRA, Humberto Graner; BARACIOLI, Luciano Moreira; SERRANO JR, Carlos Vicente; LIMA, Felipe Galego; FRANKEN, Marcelo; GIRALDEZ, Roberto Rocha; GANEM, Fernando; KALIL FILHO, Roberto; RAMIRES, José Antônio Franchini; MEHRAN, Roxana
    BACKGROUND: It is well known that the occurrence of bleeding increases in-hospital mortality in patients with acute coronary syndromes (ACS), and there is a good correlation between bleeding risk scores and bleeding incidence. However, the role of bleeding risk score as mortality predictor is poorly studied. OBJECTIVE: The main purpose of this paper was to analyze the role of bleeding risk score as in-hospital mortality predictor in a cohort of patients with ACS treated in a single cardiology tertiary center. METHODS: Out of 1655 patients with ACS (547 with ST-elevation ACS and 1118 with non-ST-elevation ACS), we calculated the ACUITY/HORIZONS bleeding score prospectively in 249 patients and retrospectively in the remaining 1416. Mortality information and hemorrhagic complications were also obtained. RESULTS: Among the mean age of 64.3 ± 12.6 years, the mean bleeding score was 18 ± 7.7. The correlation between bleeding and mortality was highly significant (p < 0.001, OR = 5.296), as well as the correlation between bleeding score and in-hospital bleeding (p < 0.001, OR = 1.058), and between bleeding score and in-hospital mortality (adjusted OR = 1.121, p < 0.001, area under the ROC curve 0.753, p < 0.001). The adjusted OR and area under the ROC curve for the population with ST-elevation ACS were, respectively, 1.046 (p = 0.046) and 0.686 ± 0.040 (p < 0.001); for non-ST-elevation ACS the figures were, respectively, 1.150 (p < 0.001) and 0.769 ± 0.036 (p < 0.001). CONCLUSIONS: Bleeding risk score is a very useful and highly reliable predictor of in-hospital mortality in a wide range of patients with acute coronary syndromes, especially in those with unstable angina or non-ST-elevation acute myocardial infarction.
  • article 2 Citação(ões) na Scopus
    Rare Manifestation of Acute Pulmonary Edema Associated with Acute Lupus Myocarditis
    (2012) SOEIRO, Alexandre de Matos; BERGAMIN, Fabricio Sanchez; ALMEIDA, Maria Carolina Feres de; SERRANO JR., Carlos Vicente; FALCAO, Breno Alencar de Araripe; GANEM, Fernando
    Systemic Lupus Erythematosus (SLE) is the most common systemic autoimmune disease, occurring more frequently in women, usually aged between 16 and 55 years1,2. Although classically the kidneys are the organs most affected in SLE, cardiopulmonary circulation and the heart may also be affected significantly3. In this context, the occurrence of acute pulmonary edema associated with lupus myocarditis is rare and specific immunosuppressive therapy remains unclear.
  • article 12 Citação(ões) na Scopus
    Características clínicas, angiográficas e evolução a longo prazo em pacientes com arterite de Takayasu e síndrome coronária aguda
    (2013) SOEIRO, Alexandre de Matos; ALMEIDA, Maria Carolina Feres de; TORRES, Tatiana Andreucci; FRANKEN, Marcelo; LIMA, Felipe Gallego; GANEM, Fernando; GIRALDEZ, Roberto R.; BARACIOLI, Luciano; TAVARES JR., Mucio Oliveira; SERRANO JR., Carlos V.; NICOLAU, Jose Carlos
    Introduction: Monitoring of disease activity and the best therapeutic approach are a challenge in Takayasu arteritis (TA). When associated with acute coronary syndromes (ACS), the best interventional treatment has not been established. The objective of this study was to describe the baseline characteristics, clinical manifestations, treatment and long-term outcome of patients with TA and ACS. Methods: We retrospectively analyzed eight patients between 2004 and 2010. The following data were obtained: age, gender, clinical and electrocardiographic manifestations, Kit lip class, risk factors for ACS, markers of myocardial necrosis (CK-MB and troponin), creatinine clearance, left ventricular ejection fraction, inflammatory markers (C-reactive protein and erythrocyte sedimentation rate [ESR]), medication during hospital stay, angiographic findings, treatment (medical, percutaneous or surgical) and long-term outcome. Statistical data were expressed as percentages and absolute values. Results: All eight patients were women, median age 49 years. Typical chest pain was present in 37.5%. Elevated ESR was observed in 85.7%. Three patients underwent coronary artery bypass grafting, three underwent percutaneous coronary angioplasty (two with bare-metal stents and one with a drug-eluting stent) and two were treated medically. In-hospital mortality was 25%. There were no deaths during a mean follow-up of 30 months. Conclusions: In our study, patients who were discharged home had good outcomes in long-term follow-up with medical, percutaneous or surgical treatment. ESR appears to be associated with ACS in TA.
  • article 33 Citação(ões) na Scopus
    Diretrizes da Sociedade Brasileira de Cardiologia sobre Angina Instável e Infarto Agudo do Miocárdio sem Supradesnível do Segmento ST (II Edição, 2007) - Atualização 2013/2014
    (2014) NICOLAU, JC; TIMERMAN, A; MARIN-NETO, JA; PIEGAS, LS; BARBOSA, CJDG; FRANCI, A; AVEZUM JR., A; CARVALHO, ACC; MARKMAN FILHO, B; POLANCZYK, CA; ROCHITTE, CE; SERRANO JÚNIOR, CV; PRECOMA, DB; SILVA JUNIOR, DG; ALBUQUERQUE, DC; STEFANINI, E; KNOBEL, E; JATENE, FB; FERES, F; MORCERF, FAP; GANEM, F; LIMA FILHO, FA; FEITOSA FILHO, GS; FERREIRA, JFM; MENEGHETTI, JC; SARAIVA, JFK; SILVA, LS; MAIA, LN; BARACIOLI, LM; LISBOA, LAF; DALLAN, LAO; BODANESE, LC; ANDRADE, MD; OLIVEIRA JÚNIOR, M; DUTRA, OP; COELHO, OR; LEÃES, PE; ALBUQUERQUE, PF; LEMOS, P; KALIL, R; COSTA, RVC; ESPORCATE, R; MARINO, RL; BOTELLHO, RV; MENEGHELO, RS; SPROVIERI, SR; TIMERMAN, S; MATHIAS JÚNIOR, W
  • article 2 Citação(ões) na Scopus
    Influence of proven oral therapies in the very old with acute coronary syndromes: A 15 year experience
    (2015) NICOLAU, Jose C.; FRANCI, Andre; BARBOSA, Carlos Jose D. G.; BARACIOLI, Luciano M.; FRANKEN, Marcelo; FURTADO, Remo H. M.; GIRALDEZ, Roberto R. C. V.; GANEM, Fernando; LIMA, Felipe G.; MENEZES, Fernando R.; ARANTES, Flavia B. B.; RAMIRES, Jose A. F.; KALIL FILHO, Roberto; GIUGLIANO, Robert P.
  • article 15 Citação(ões) na Scopus
    Preoperative B-type natriuretic peptide, and not the inflammation status, predicts an adverse outcome for patients undergoing heart surgery
    (2011) GANEM, Fernando; SERRANO JR., Carlos V.; FERNANDES, Juliano L.; BLOTTA, Maria Heloisa S. L.; SOUZA, Juliana A.; NICOLAU, Jose C.; RAMIRES, Jose A. F.; HUEB, Whady A.
    Objectives: B-type natriuretic peptide (BNP) and inflammatory markers are implicated in the pathophysiology of both ischemic cardiomyopathy and complications after cardiac surgery with cardiopulmonary bypass (CPB). The purpose of this study was to assess preoperative and postoperative levels of BNP, interleukin-6 (IL-6), interleukin-8 (IL-8), P-selectin, intercellular adhesion molecule (ICAM), C-reactive protein (CRP) in patients undergoing cardiac surgery with CPB and investigate their variation and ability to correlate with immediate outcome. Methods: Plasma levels of these markers were measured preoperatively, 6 and 24 h after CBP in 62 patients. Main endpoints were requirements for intra-aortic balloon pump, intensive care unit (ICU) stay longer than five days, ventilator dependence >24 h, requirement for dobutamine, hospital stay >10 days, clinical complications (infection, myocardial infarction, renal failure, stroke and ventricular arrhythmias) and in-hospital mortality. Results: Preoperative BNP levels correlate with longer ICU stay (P=0.003), longer ventilator use (P=0.018) and duration of dobutamine use (P<0.001). The receiver-operating characteristic curve demonstrated BNP levels >190 pg/ml as predictor of ICU >5 days and BNP levels >20.5 pg/ml correlated with dobutamine use, with areas under the curve of 0.712 and 0.842, respectively. Preoperative levels of ICAM-1 were associated with in-hospital mortality (P=0.042). In the postoperative period, was found association between CRP, IL-6 and P-selectin with ventilation duration (P=0.013, P=0.006, P<0.001, respectively) and P-selectin with ICU stay (P=0.009). Conclusions: BNP correlates with clinical endpoints more than inflammatory markers and can be used as a predictor of early outcome after heart surgery.
  • article 15 Citação(ões) na Scopus
    Diretrizes Brasileiras de antiagregantes plaquetários e anticoagulantes em cardiologia
    (2013) LORGA FILHO, A. M.; AZMUS, A. D.; SOEIRO, A. M.; QUADROS, A. S.; AVEZUM JUNIOR, A.; MARQUES, A. C.; FRANCI, A.; MANICA, A. L. L.; VOLSCHAN, A.; V, A. A. De Paola; GRECO, A. I. L.; FERREIRA, A. C. N.; SOUSA, A. C. S.; PESARO, A. E. P.; SIMAO, A. F.; LOPES, A. S. S. A.; TIMERMAN, A.; RAMOS, A. I. O.; ALVES, B. R.; CARAMELLI, B.; MENDES, B. A.; POLANCZYK, C. A.; MONTENEGRO, C. E. L.; BARBOSA, C. J. D. G.; V, C. Serrano Junior; MELO, C. C. L.; PINHO, C.; MOREIRA, D. A. R.; CALDERARO, D.; GUALANDRO, D. M.; ARMAGANIJAN, D.; MACHADO NETO, E. A.; BOCCHI, E. A.; PAIVA, E. F.; STEFANINI, E.; D'AMICO, E.; EVARISTO, E. F.; SILVA, E. E. R.; FERNANDES, F.; BRITO JUNIOR, F. S.; BACAL, F.; GANEM, F.; GOMES, F. L. T.; MATTOS, F. R.; MORAES NETO, F. R.; TARASOUTCHI, F.; DARRIEUX, F. C. C.; FEITOSA, G. S.; FENELON, G.; MORAIS, G. R.; CORREA FILHO, H.; CASTRO, I; GONCALVES JUNIOR, I; ATIE, J.; SOUZA NETO, J. D.; FERREIRA, J. F. M.; NICOLAU, J. C.; FARIA NETO, J. R.; ANNICHINO-BIZZACCHI, J. M.; I, L. Zimerman; PIEGAS, L. S.; PIRES, L. J. T.; BARACIOLI, L. M.; SILVA, L. B.; MATTOS, L. A. P.; LISBOA, L. A. F.; MAGALHAES, L. P. M.; LOPES, M. A. C. Q.; MONTERA, M. W.; FIGUEIREDO, M. J. O.; MALACHIAS, M. V. B.; GAZ, M. V. B.; ANDRADE, M. D.; BACELLAR, M. S. C.; BARBOSA, M. R.; CLAUSELL, N. O.; DUTRA, O. P.; COELHO, O. R.; YU, P. C.; LAVITOLA, P. L.; LEMOS NETO, P. A.; ANDRADE, P. B.; FARSKY, P. S.; FRANCO, R. A.; KALIL, R. A. K.; LOPES, R. D.; ESPORCATTE, R.; HEINISCH, R. H.; KALIL FILHO, R.; V, R. R. C. Giraldez; ALVES, R. C.; LEITE, R. E. G. S.; GAGLIARDI, R. J.; RAMOS, R. F.; MONTENEGRO, S. T.; ACCORSI, T. A. D.; V, T. S. Jardim; SCUDELER, T. L.; MOISES, V. A.; PORTAL, V. L.
  • conferenceObject
    Early oral betablocker utilization reduces in-hospital mortality in patients submitted to primary percutaneous coronary intervention: a real-world analysis
    (2017) FURTADO, R. H. M.; DALCOQUIO, T. F.; NAKASHIMA, C. A. K.; SCANAVINI FILHO, M. A.; PEREIRA, C. A. C.; LARA, L. M.; GANEM, F.; GIRALDEZ, R. R. C. V.; FRANKEN, M.; KALIL FILHO, R.; NICOLAU, J. C.
  • article 31 Citação(ões) na Scopus
    Update on the Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Guideline of the Brazilian Society of Cardiology-2019
    (2019) BERNOCHE, Claudia; TIMERMAN, Sergio; POLASTRI, Thatiane Facholi; GIANNETTI, Natali Schiavo; SIQUEIRA, Adailson Wagner da Silva; PISCOPO, Agnaldo; SOEIRO, Alexandre de Matos; REIS, Amelia Gorete Afonso da Costa; TANAKA, Ana Cristina Sayuri; THOMAZ, Ana Maria; QUILICI, Ana Paula; CATARINO, Andrei Hilario; RIBEIRO, Anna Christina de Lima; BARRETO, Antonio Carlos Pereira; AZEVEDO FILHO, Antonio Fernando Barros de; PAZIN FILHO, Antonio; TIMERMAN, Ari; SCARPA, Bruna Romanelli; TIMERMAN, Bruno; TAVARES, Caio de Assis Moura; MARTINS, Cantidio Soares Lemos; SERRANO JUNIOR, Carlos Vicente; MALAQUE, Ceila Maria Sant'Ana; PISANI, Cristiano Faria; BATISTA, Daniel Valente; LEANDRO, Daniela Luana Fernandes; SZPILMAN, David; GONCALVES, Diego Manoel; PAIVA, Edison Ferreira de; OSAWA, Eduardo Atsushi; LIMA, Eduardo Gomes; ADAM, Eduardo Leal; PEIXOTO, Elaine; EVARISTO, Eli Faria; AZEKA, Estela; SILVA, Fabio Bruno da; WEN, Fan Hui; FERREIRA, Fatima Gil; LIMA, Felipe Gallego; FERNANDES, Felipe Lourenco; GANEM, Fernando; GALAS, Filomena Regina Barbosa Gomes; TARASOUTCHI, Flavio; SOUZA, Germano Emilio Conceicao; FEITOSA FILHO, Gilson Soares; FORONDA, Gustavo; GUIMARAES, Helio Penna; ABUD, Isabela Cristina Kirnew; LEITE, Ivanhoe Stuart Lima; LINHARES FILHO, Jaime Paula Pessoa; MORAES JUNIOR, Joao Batista de Moura Xavier; FALCAO, Joao Luiz Alencar de Araripe; RAMIRES, Jose Antonio Franchini; CAVALINI, Jose Fernando; SARAIVA, Jose Francisco Kerr; ABRAO, Karen Cristine; PINTO, Lecio Figueira; BIANCHI, Leonardo Luis Torres; LOPES, Leonardo Nicolau Geisler Daud; PIEGAS, Leopoldo Soares; KOPEL, Liliane; GODOY, Lucas Colombo; TOBASE, Lucia; HAJJAR, Ludhmila Abrahao; DALLAN, Luis Augusto Palma; CANEO, Luiz Fernando; CARDOSO, Luiz Francisco; CANESIN, Manoel Fernandes; PARK, Marcelo; RABELO, Marcia Maria Noya; MALACHIAS, Marcus Vinicius Bolivar; GONCALVES, Maria Aparecida Batistao; ALMEIDA, Maria Fernanda Branco de; SOUZA, Maria Francilene Silva; FAVARATO, Maria Helena Sampaio; CARRION, Maria Julia Machline; GONZALEZ, Maria Margarita; BORTOLOTTO, Maria Rita de Figueiredo Lemos; MACATRAO-COSTA, Milena Frota; SHIMODA, Monica Satsuki; OLIVEIRA-JUNIOR, Mucio Tavares de; IKARI, Nana Miura; DUTRA, Oscar Pereira; BERWANGER, Otavio; PINHEIRO, Patricia Ana Paiva Correa; REIS, Patricia Feitosa Frota dos; CELLIA, Pedro Henrique Moraes; SANTOS FILHO, Raul Dias dos; GIANOTTO-OLIVEIRA, Renan; KALIL FILHO, Roberto; GUINSBURG, Ruth; MANAGINI, Sandrigo; LAGE, Silvia Helena Gelas; YEU, So Pei; FRANCHI, Sonia Meiken; SHIMODA-SAKANO, Tania; ACCORSI, Tarso Duenhas; LEAL, Tatiana de Carvalho Andreucci; GUIMARAES, Vanessa; SALLAI, Vanessa Santos; AVILA, Walkiria Samuel; SAKO, Yara Kimiko