THIAGO LUIS SCUDELER
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
9 resultados
Resultados de Busca
Agora exibindo 1 - 9 de 9
- Myocardial injury in diabetic patients with multivessel coronary artery disease after revascularization interventions(2017) REZENDE, Paulo Cury; HUEB, Whady; RAHMI, Rosa Maria; SCUDELER, Thiago Luis; AZEVEDO, Diogo Freitas Cardoso de; GARZILLO, Cibele Larrosa; SEGRE, Carlos Alexandre Wainrober; RAMIRES, Jose Antonio Franchini; KALIL FILHO, RobertoBackground: Diabetic patients may be more susceptible to myocardial injury after coronary interventions. Thus, the aim of this study was to assess the release of cardiac biomarkers, CK-MB and troponin, and the findings of new late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) in patients with type 2 diabetes mellitus after elective revascularization procedures for multivessel coronary artery disease (CAD). Methods: Patients with multivessel CAD and preserved systolic ventricular function underwent either elective percutaneous coronary intervention (PCI), off-pump or on-pump bypass surgery (CABG). Troponin and CK-MB were systematically collected at baseline, 6, 12, 24, 36, 48 and 72 h after the procedures. CMR with LGE was performed before and after the interventions. Patients were stratified according to diabetes status at study entry. Biomarkers and CMR results were compared between diabetic and nondiabetics patients. Analyses of correlation were also performed among glycemic and glycated hemoglobin (A1c) levels and troponin and CK-MB peak levels. Patients were also stratified into tertiles of fasting glycemia and A1c levels and were compared in terms of periprocedural myocardial infarction (PMI) on CMR. Results: Ninety (44.5%) of the 202 patients had diabetes mellitus at study entry. After interventions, median peak troponin was 2.18 (0.47, 5.14) and 2.24 (0.69, 5.42) ng/mL (P = 0.81), and median peak CK-MB was 14.1 (6.8, 31.7) and 14.0 (4.2, 29.8) ng/mL (P = 0.43), in diabetic and nondiabetic patients, respectively. The release of troponin and CK-MB over time was statistically similar in both groups and in the three treatments, besides PCI. New LGE on CMR indicated that new myocardial fibrosis was present in 18.9 and 17.3% (P = 0.91), and myocardial edema in 15.5 and 22.9% (P = 0.39) in diabetic and nondiabetic patients, respectively. The incidence of PMI in the glycemia tertiles was 17.9% versus 19.3% versus 18.7% (P = 0.98), and in the A1c tertiles was 19.1% versus 13.3% versus 22.2% (P = 0.88). Conclusions: In this study, diabetes mellitus did not add risk of myocardial injury after revascularization interventions in patients with multivessel coronary artery disease.
bookPart Pericardiopatias(2017) SCUDELER, Thiago LuisconferenceObject Cost-Effectiveness Comparative Study for Clinical, Surgical or Percutaneous Treatment in Patients With Stable Multivessel Coronary Artery Disease: 10 Year Follow-Up(2017) MAGALHAES, Cibelle D.; HUEB, Whady; SCUDELER, Thiago; FAVARATO, Desiderio; LIMA, Eduardo; VIEIRA, Ricardo D.; BOCCHI, EdimarconferenceObject Impact of chronic kidney dysfunction among patients with stable coronary artery disease: ten-year follow-up of mass II trial(2017) LIMA, E. G.; HUEB, W.; GARZILLO, C. L.; FAVARATO, D.; SEGRE, C. A. W.; AZEVEDO, D. F. C.; HUEB, A. C.; REZENDE, P. C.; SILVA, E. E. R.; GARCIA, R. M. R.; SCUDELER, T. L.; RAMIRES, J. A. F.; KALIL FILHO, R.conferenceObject Quality of life and economic outcomes of on-pump and off-pump stable multivessel coronary artery bypass grafting - MASS III trial 5-year follow-up(2017) SCUDELER, T. L.; HUEB, W.; SOAREZ, P. C. De; CAMPOLINA, A. G.; REZENDE, P. C.; LIMA, E. G.; GARZILLO, C. L.; AZEVEDO, D. F. C.; COSTA, L. M. A.; OIKAWA, F. T. C.; RAMIRES, J. A. F.; KALIL FILHO, R.conferenceObject COST-EFFECTIVENESS ANALYSIS AND QUALITY OF LIFE OF ON-PUMP AND OFF-PUMP STABLE MULTIVESSEL CORONARY ARTERY BYPASS GRAFTING: MASS III TRIAL 5-YEAR FOLLOW-UP(2017) SCUDELER, Thiago; HUEB, Whady; SOAREZ, Patricia Coelho De; CAMPOLINA, Alessandro G.; REZENDE, Paulo; LIMA, Eduardo; GARZILLO, Cibele Larrosa; FREITAS, Diogo Freitas Cardoso; COSTA, Leandro; OIKAWA, Fernando Teiichi; RAMIRES, Jose; KALIL FILHO, RobertobookPart Pericardiocentese(2017) SCUDELER, Thiago LuisconferenceObject Cost-effectiveness of On-pump and Off-pump Stable Multivessel Coronary Artery Bypass Grafting - MASS III Trial 5-year Follow-up(2017) SCUDELER, Thiago L.; HUEB, Whady; SOAREZ, Patricia C. de; CAMPOLINA, Alessandro G.; REZENDE, Paulo C.; GARZILLO, Cibele L.; LIMA, Eduardo G.; AZEVEDO, Diogo F.; HUEB, Alexandre C.; LINHARES FILHO, Jaime P.; RAMIRES, Jose A.; KALIL FILHO, RobertoconferenceObject Impact of SYNTAX score on release of cardiac biomarkers in post-revascularization procedures among patients with stable multivessel disease: MASS-V insights(2017) AZEVEDO, D. F. C.; HUEB, W.; LIMA, E. G.; REZENDE, P. C.; GARZILLO, C. L.; STRUNZ, C. M. C.; NOMURA, C. H.; SEGRE, C. A. W.; FAVARATO, D.; SCUDELER, T. L.; HUEB, A. C.; SILVA, E. E. R.; GARCIA, R. M. R.; RAMIRES, J. A. F.; KALIL FILHO, R.