CARLOS VICENTE SERRANO JUNIOR
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
9 resultados
Resultados de Busca
Agora exibindo 1 - 9 de 9
- RAMB: NEW PATHWAYS(2014) SERRANO, Carlos V.
conferenceObject Defective function of hdl particles in familial apolipoprotein A-I deficiency: relevance of alterations in the lipidome(2014) RACHED, F.; SANTOS, R. Dos; MINAME, M.; LHOMME, M.; DAUTEILLE, C.; SERRANO JR., C. V.; CHAPMAN, J.; KONTUSH, A.- Clinical characteristics and in-hospital outcome of patients with acute coronary syndromes and systemic lupus erythematosus(2014) SOEIRO, Alexandre de Matos; SOEIRO, Maria Carolina Feres de Almeida; OLIVEIRA JR., Mucio Tavares de; SERRANO JR., Carlos VienteObjective: Due to the chronic inflammation associated with systemic lupus erythematosus (SLE), patients develop premature atherosclerosis and the disease is a risk factor for acute myocardial infarction. The best interventional treatment for acute coronary syndrome (ACS) in these patients is unclear. The objective of this study is to describe the baseline characteristics, clinical manifestations, treatment and in-hospital outcome of patients with SLE and ACS. Methods: Eleven SLE patients with ACS were analyzed retrospectively between 2004 and 2011. The following data were obtained: age, gender, clinical and electrocardiographic characteristics, Killip class, risk factors for ACS, myocardial necrosis markers (CK-MB and troponin), creatinine clearance, left ventricular ejection fraction, inflammatory markers (C-reactive protein and erythrocyte sedimentation rate), drugs used during hospital stay, treatment (medical, percutaneous or surgical) and in-hospital outcome. The statistical analysis is presented in percentages and absolute values. Results: Ten of the patients (91%) were women. The median age was 47 years. Typical precordial pain was present in 91%. Around 73% had positive erythrocyte sedimentation rate. The vessel most often affected was the anterior descending artery, in 73%. One patient underwent coronary artery bypass grafting, seven underwent percutaneous coronary intervention with bare-metal stents and three were treated medically. In-hospital mortality was 18%. Conclusions: Despite the small number of patients, our findings were similar to those in the literature, showing coronary artery disease in young people with SLE due to premature atherosclerosis and a high mortality rate.
- Diretrizes da Sociedade Brasileira de Cardiologia sobre Angina Instável e Infarto Agudo do Miocárdio sem Supradesnível do Segmento ST (II Edição, 2007) - Atualização 2013/2014(2014) NICOLAU, JC; TIMERMAN, A; MARIN-NETO, JA; PIEGAS, LS; BARBOSA, CJDG; FRANCI, A; AVEZUM JR., A; CARVALHO, ACC; MARKMAN FILHO, B; POLANCZYK, CA; ROCHITTE, CE; SERRANO JÚNIOR, CV; PRECOMA, DB; SILVA JUNIOR, DG; ALBUQUERQUE, DC; STEFANINI, E; KNOBEL, E; JATENE, FB; FERES, F; MORCERF, FAP; GANEM, F; LIMA FILHO, FA; FEITOSA FILHO, GS; FERREIRA, JFM; MENEGHETTI, JC; SARAIVA, JFK; SILVA, LS; MAIA, LN; BARACIOLI, LM; LISBOA, LAF; DALLAN, LAO; BODANESE, LC; ANDRADE, MD; OLIVEIRA JÚNIOR, M; DUTRA, OP; COELHO, OR; LEÃES, PE; ALBUQUERQUE, PF; LEMOS, P; KALIL, R; COSTA, RVC; ESPORCATE, R; MARINO, RL; BOTELLHO, RV; MENEGHELO, RS; SPROVIERI, SR; TIMERMAN, S; MATHIAS JÚNIOR, W
- Miocardite Clinicamente Manifesta em Surto Agudo de Febre Reumatica(2014) XAVIER JR., Jose L.; SOEIRO, Alexandre de Matos; LOPES, Antonio S. S. A.; SPINA, Guilherme S.; SERRANO JR., Carlos V.; OLIVEIRA JR., Mucio T.
- Intracardiac embolization of inferior vena cava filter associated with right atrium perforation and cardiac tamponade(2014) SOEIRO, Alexandre de Matos; FERNANDES, Felipe Lourenco; TEIXEIRA, Rafael Plens; NICZ, Pedro Felipe Gomez; SOEIRO, Maria Carolina Feres de Almeida; SERRANO JR., Carlos V.; OLIVEIRA JR., Mucio Tavares deInsertion of inferior vena cava filters has been well established in literature, reducing occurrence of pulmonary embolism after an episode of deep venous thrombosis in patients with contraindication to anticoagulation. There are a small number of complications related to procedure and embolization is rare. In this context, we described a case of intracardiac embolization associated with cardiac tamponade.
- Defective functionality of HDL particles in familial apoA-I deficiency: relevance of alterations in HDL lipidome and proteome(2014) RACHED, Fabiana; SANTOS, Raul D.; CAMONT, Laurent; MINAME, Marcio H.; LHOMME, Marie; DAUTEUILLE, Carolane; LECOCQ, Sora; SERRANO JR., Carlos V.; CHAPMAN, M. John; KONTUSH, AnatolTo evaluate functional and compositional properties of HDL in subjects from a kindred of genetic apoA-I deficiency, two homozygotes and six heterozygotes, with a nonsense mutation at APOA1 codon -2, Q[-2]X, were recruited together with age- and sex-matched healthy controls (n = 11). Homozygotes displayed undetectable plasma levels of apoA-I and reduced levels of HDL-cholesterol (HDL-C) and apoC-III (5.4% and 42.6% of controls, respectively). Heterozygotes displayed low HDL-C (21 +/- 9 mg/dl), low apoA-I (79 +/- 24 mg/dl), normal LDL-cholesterol (132 +/- 25 mg/dl), and elevated TG (130 +/- 45 mg/dl) levels. Cholesterol efflux capacity of ultracentrifugally isolated HDL subpopulations was reduced (up to -25%, P < 0.01, on a glycerophospholipid [GP] basis) in heterozygotes versus controls. Small, dense HDL3 and total HDL from heterozygotes exhibited diminished antioxidative activity (up to -48%, P < 0.001 on a total mass basis) versus controls. HDL subpopulations from both homozygotes and heterozygotes displayed altered chemical composition, with depletion in apoA-I, GP, and cholesteryl ester; enrichment in apoA-II, free cholesterol, and TG; and altered phosphosphingolipidome. The defective atheroprotective activities of HDL were correlated with altered lipid and apo composition. These data reveal that atheroprotective activities of HDL particles are impaired in homozygous and heterozygous apoA-I deficiency and are intimately related to marked alterations in protein and lipid composition.
conferenceObject DEFECTIVE FUNCTION OF HDL PARTICLES IN FAMILIAL APOLIPOPROTEIN A-I DEFICIENCY: RELEVANCE OF ALTERATIONS IN THE LIPIDOME(2014) RACHED, F.; SANTOS, R. D.; MINAME, M.; LHOMME, M.; DAUTEILLE, C.; SERRANO, C. V.; CHAPMAN, M. J.; KONTUSH, A.conferenceObject Long term prognosis of acute coronary syndromes submitted to angioplasty in culprit vessel only-Comparison between complete treatment versus residual lesion(2014) SOEIRO, A.; LEAL, T. C. A. T.; SOEIRO, M. C. F. A.; PAULA, L. J. C.; GOLDSTEIN, P. G.; LAGE, R. L.; SERRANO JR., C. V.; HAJJAR, L. A.; OLIVEIRA JR., M. T.