CARLOS VICENTE SERRANO JUNIOR

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Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina

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  • article 11 Citação(ões) na Scopus
    Aspirin underuse, non-compliance or cessation: Definition, extent, impact and potential solutions in the primary and secondary prevention of cardiovascular disease
    (2015) BIONDI-ZOCCAI, Giuseppe; WU, Yangfeng; SERRANO JR., Carlos V.; FRATI, Giacomo; AGOSTONI, Pierfrancesco; ABBATE, Antonio
    Despite momentous breakthroughs in unraveling the pathophysiology of many chronic conditions and developing novel therapeutic agents, everyday clinical practice is still fraught with inadequate or inappropriate use of treatments with proven benefits. Aspirin is a paradigmatic example, as it is used for the primary and secondary prevention of cardiovascular disease and appears to have a beneficial impact on cancer risk. Yet, underuse, noncompliance or cessation of aspirin are not uncommon, may have an important clinical impact, and are not aggressively prevented or managed. Increasing the awareness of the extent and impact of aspirin underuse, noncompliance or cessation, and intensifying efforts at preventing them are worthy goals likely to yield significant benefits on cardiovascular morbidity and mortality worldwide, and possibly also on cancer outcomes.
  • conferenceObject
    Suspected Acute Coronary Syndrome With Normal Coronary Arteries: The Value of Cardiac Magnetic Resonance in Changes of Treatment
    (2015) SOEIRO, Alexandre M.; NAKAMURA, Debora Y.; LEAL, Tatiana C.; BOSSA, Aline S.; SOEIRO, Maria C.; SERRANO JR., Carlos V.; OLIVEIRA JR., Mocio T.
  • article 11 Citação(ões) na Scopus
    Prognostic Value of Serial Brain Natriuretic Peptide Measurements in Patients with Acute Myocardial Infarction
    (2015) PESARO, Antonio E. P.; KATZ, Marcelo; CAIXETA, Adriano; MAKDISSE, Marcia R.; CORREIA, Alessandra G.; PEREIRA, Carolina; FRANKEN, Marcelo; FAVA, Anderson N.; SERRANO JR., Carlos V.
    Objectives: Elevated B-type natriuretic peptide (BNP) levels following acute myocardial infarction (AMI) are associated with adverse outcomes. The role of serial BNP monitoring after AMI has been poorly investigated. We aimed to evaluate the prognostic value of in-hospital serial BNP measurements in AMI patients. Methods: Patients with AMI (n = 1,924) were retrospectively evaluated. We selected patients with at least 2 in-hospital BNP measurements. The association between in-hospital mortality and BNP measurements (earliest, highest follow-up and the variation between measurements) were tested in multivariate models. Results: Serial BNP levels were determined in 176 patients. Compared to the rest of the population, these patients were older and had higher mortality rates. In the adjusted models, only the highest follow-up BNP remained associated with in-hospital death (odds ratio 1.06; 95% confidence interval, Cl, 1.01 -1.15; p = 0.014). Receiver-operating characteristic curve analysis demonstrated that the highest follow-up BNP was the best predictor of in-hospital death (area under the curve = 0.75; 95% CI 0.64-0.86). Conclusions: Serial BNP monitoring was performed in a high-risk subgroup of AMI patients. The highest follow-up BNP was a better predictor of short-term death than the baseline and in-hospital variation values. In AMI patients, a later in-hospital BNP assessment may be more useful than an early measurement. (C) 2015 S. Karger AG, Basel
  • article 51 Citação(ões) na Scopus
    Defective functionality of small, dense HDL3 subpopulations in ST segment elevation myocardial infarction: Relevance of enrichment in lysophosphatidylcholine, phosphatidic acid and serum amyloid A
    (2015) RACHED, Fabiana; LHOMME, Marie; CAMONT, Laurent; GOMES, Fernando; DAUTEUILLE, Carolane; ROBILLARD, Paul; SANTOS, Raul D.; LESNIK, Philippe; SERRANO JR., Carlos V.; CHAPMAN, M. John; KONTUSH, Anatol
    Background: Low plasma levels of high-density lipoprotein-cholesterol (HDL-C) are typical of acute myocardial infarction (MI) and predict risk of recurrent cardiovascular events. The potential relationships between modifications in the molecular composition and the functionality of HDL subpopulations in acute MI however remain indeterminate. Methods and results: ST segment elevation MI (STEMI) patients were recruited within 24 h after diagnosis (n = 16) and featured low HDL-C (-31%, p < 0.05) and acute-phase inflammation (determined as marked elevations in C-reactive protein, serum amyloid A (SAA) and interleukin-6) as compared to age- and sex-matched controls (n = 10). STEM! plasma HDL and its subpopulations (HDL2b, 2a, 3a, 3b, 3c) displayed attenuated cholesterol efflux capacity from THP-1 cells (up to -32%, p < 0.01, on a unit phospholipid mass basis) vs. controls. Plasma HDL and small, dense HDL3b and 3c subpopulations from STEMI patients exhibited reduced anti-oxidative activity (up to 68%, p < 0.05, on a unit HDL mass basis). HDL subpopulations in STEMI were enriched in two proinflammatory bioactive lipids, lysophosphatidylcholine (up to 3.0-fold, p < 0.05) and phosphatidic acid (up to 8.4-fold, p < 0.05), depleted in apolipoprotein A-I (up to 23%, p < 0.05) and enriched in SAA (up to + 10.2-fold, p < 0.05); such changes were most marked in the HDL3b subfraction. In vitro HDL enrichment in both lysophosphatidylcholine and phosphatidic acid exerted deleterious effects on HDL functionality. Conclusions: In the early phase of STEM!, HDL particle subpopulations display marked, concomitant alterations in both lipidome and proteome which are implicated in impaired HDL functionality. Such modifications may act synergistically to confer novel deleterious biological activities to STEM! HDL Significance: Our present data highlight complex changes in the molecular composition and functionality of HDL particle subpopulations in the acute phase of STEMI, and for the first time, reveal that concomitant modifications in both the lipidome and proteome contribute to functional deficiencies in cholesterol efflux and antioxidative activities of HDL particles. These findings may provide new biomarkers and new insights in therapeutic strategy-to reduce cardiovascular risk in this clinical setting where such net deficiency in HDL function, multiplied by low circulating HDL concentrations, can be expected to contribute to accelerated atherogenesis.
  • article 60 Citação(ões) na Scopus
    V Diretriz da Sociedade Brasileira de Cardiologia sobre Tratamento do Infarto Agudo do Miocárdio com Supradesnível do Segmento ST
    (2015) PIEGAS, L. S.; TIMERMAN, A.; FEITOSA, G. S.; NICOLAU, J. C.; MATTOS, L. A. P.; ANDRADE, M. D.; AVEZUM, A.; FELDMAN, A.; CARVALHO, A. C. C. De; SOUSA, A. C. S.; MANSUR, A. P.; BOZZA, A. E. Z.; FALCAO, B. A. A.; MARKMAN FILHO, B.; POLANCZYK, C. A.; GUN, C.; V, C. Serrano Junior; OLIVEIRA, C. C.; MOREIRA, D.; PRECOMA, D. B.; MAGNONI, D.; ALBUQUERQUE, D. C.; ROMANO, E. R.; STEFANINI, E.; SANTOS, E. S.; GOD, E. M. G.; RIBEIRO, E. E.; BRITO JUNIOR, F. S.; FEITOSA-FILHO, G. S.; ARRUDA, G. D. S.; OLIVEIRA, G. B. F.; OLIVEIRA, G. B. F.; LIMA, G. G.; DOHMANN, H. F. R.; LIGUORI, I. M.; COSTA, J. R.; SARAIVA, J. F. K.; MAIA, L. N.; MOREIRA, L. F. P.; ARRAIS, M.; CANESIN, M. F.; COUTINHO, M. S. S. A.; MORETTI, M. A.; GHORAYEB, N.; VIEIRA, N. W.; DUTRA, O. P.; COELHO, O. R.; LEAES, P. E.; ROSSI, P. R. F.; ANDRADE, P. B.; LEMOS, P. A.; PAVANELLO, R.; COSTA, Vivacqua R. C.; BASSAN, R.; ESPORCATTE, R.; MIRANDA, R.; V, R. R. C. Giraldez; RAMOS, R. F.; MARTINS, S. K.; ESTEVES, V. B. C.; MATHIAS JUNIOR, W.
  • bookPart
    Obesidade e doença cardiovascular tromboembólica
    (2015) SOEIRO, Alexandre de Matos; GOMES, Fernando Luiz Torres; LEAL, Tatiana de Carvalho Andreuci Torres; SETANI, Karina Tiemi; SAKAMOTO, Erica; SERRANO JR., Carlos V.
  • article 18 Citação(ões) na Scopus
    Clinical characteristics and long-term progression of young patients with acute coronary syndrome in Brazil
    (2015) SOEIRO, Alexandre de Matos; FERNANDES, Felipe Lourenço; SOEIRO, Maria Carolina Feres de Almeida; SERRANO JR, Carlos Vicente; OLIVEIRA JR, Múcio Tavares de
    Objective In Brazil, there are few descriptions in the literature on the angiographic pattern and clinical characteristics of young patients with acute coronary syndrome, despite the evident number of cases in the population. The objective of this study was to evaluate which clinical characteristics are most closely related to the acute coronary syndrome in young patients, and what long-term outcomes are in this population.Methods This is a prospective observational study with 268 patients aged under 55 years with acute coronary syndrome, carried out between May 2010 and May 2013. Data were obtained on demographics, laboratory test and angiography results, and the coronary treatment adopted. Statistical analysis was presented as percentages and absolute values.Results Approximately 57% were men and the median age was 50 years (30 to 55). The main risk factors were arterial hypertension (68%), smoking (67%), and dyslipidemia (43%). Typical pain was present in 90% of patients. In young individuals, 25.7% showed ST segment elevation. Approximately 56.5% of patients presented with a single-vessel angiographic pattern. About 7.1% were submitted to coronary bypass surgery, and 42.1% to percutaneous coronary angioplasty. Intrahospital mortality was 1.5%, and the combined event rate (cerebrovascular accident/stroke, cardiogenic shock, reinfarction, and arrhythmias) was 13.8%. After a mean follow-up of 10 months, mortality was 9.8%, while 25.4% of the patients had new ischemic events, and 37.3% required readmission to hospital.Conclusion In the short-term, young patients presented with mortality rates below what was expected when compared to the rates noted in other studies. However, there was a significant increase in the number of events in the 10-month follow-up.
  • bookPart
    Síndrome coronária aguda em pacientes jovens
    (2015) SOEIRO, Alexandre de Matos; MARTINELLI, Luiz Mario Baptista; SERRANO JR., Carlos Vicente; GIRALDEZ, Roberto Rocha Correa Veiga
  • bookPart
    Síndrome coronária aguda em pacientes jovens
    (2015) SOEIRO, Alexandre de Matos; MARTINELLI, Luiz Mario Baptista; SERRANO JR., Carlos Vicente; GIRALDEZ, Roberto Rocha Correa Veiga
  • bookPart
    Síndrome coronária aguda em pacientes em uso de antiocoagulação oral
    (2015) SOEIRO, Alexandre de Matos; SERRANO JR., Carlos Vicente