ALEX JONES FLORES CASSENOTE
Projetos de Pesquisa
Unidades Organizacionais
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
- The HIV-Brazil Cohort Study: Design, Methods and Participant Characteristics(2014) GRANGEIRO, Alexandre; ESCUDER, Maria Mercedes; CASSANOTE, Alex Jones Flores; SOUZA, Rosa Alencar; KALICHMAN, Artur O.; VELOSO, Valdilea; IKEDA, Maria Leticia Rodrigues; BARCELLOS, Nemora Tregnago; BRITES, Carlos; TUPINANBAS, Unai; LUCENA, Noaldo O.; SILVA, Carlos Lima da; LACERDA, Heloisa Ramos; GRINSZTEJN, Beatriz; CASTILHO, Euclides AyresBackground: The HIV-Brazil Cohort Study was established to analyze the effectiveness of combination antiretroviral therapy (cART) and the impact of this treatment on morbidity, quality of life (QOL) and mortality. The study design, patients' profiles and characteristics of cART initiation between 2003 and 2010 were described. Methodology/Principal Findings: Since 2003, the HIV-Brazil Cohort has been following HIV-infected adults receiving cART at 26 public health care facilities, using routine clinical care data and self-reported QOL questionnaires. When not otherwise available, data are obtained from national information systems. The main outcomes of interest are diseases related or unrelated to HIV; suppression of viral replication; adverse events; virological, clinical and immunological failures; changes in the cART; and mortality. For the 5,061 patients who started cART between 2003 and 2010, the median follow-up time was 4.1 years (IQR 2.2-5.9 years) with an 83.4% retention rate. Patient profiles were characterized by a predominance of men (male/female ratio 1.7:1), with a mean age of 36.9 years (SD 9.9 years); 55.2% had been infected with HIV via heterosexual contact. The majority of patients (53.4%) initiated cART with a CD4(+) T-cell count <= 200 cells/mm(3). The medications most often used in the various treatment regimens were efavirenz (59.7%) and lopinavir/ritonavir (18.2%). The proportion of individuals achieving viral suppression within the first 12 months of cART use was 77.4% (95% CI 76.1-78.6). Nearly half (45.4%) of the patients presented HIV-related clinical manifestations after starting cART, and the AIDS mortality rate was 13.9 per 1,000 person-years. Conclusions/Significance: Results from cART use in the daily practice of health services remain relatively unknown in low- and middle-income countries, and studies with the characteristics of the HIV-Brazil Cohort contribute to minimizing these shortcomings, given its scope and patient profile, which is similar to that of the AIDS epidemic in the country.
- Potential biases in the classification, analysis and interpretations in cross-sectional study: commentaries - surrounding the article ""resting heart rate: its correlations and potential for screening metabolic dysfunctions in adolescents""(2014) MORAES, Augusto Cesar Ferreira de; CASSENOTE, Alex Jones Flores; MORENO, Luis A.; CARVALHO, Herclito BarbosaBackground: Resting heart rate reflects sympathetic nerve activity. A significant association between resting heart rate (HR) and all causes of cardiovascular mortality has been reported by some epidemiologic studies. Despite suggestive evidence, resting heart rate (RHR) has not been formally explored as a prognostic factor and potential therapeutic outcome and, therefore, is not generally accepted in adolescents. Discussion: The core of the debate is the methodological aspects used in ""Resting heart rate: its correlations and potential for screening metabolic dysfunctions in adolescents""; the points are: cutoff used for cluster RHR, two different statistical models used to analyze the same set of variables, one for continuous data, and another for categorical data; interpretation of p-value < 0.05, sampling process involving two random stages, analysis of design effect and the parameters of screening tests. Summary: Aspects that must be taken into account for evaluation of a screening test to measure the potential for discrimination for a common variable (population with outcome vs. no outcome population), the main indicators are: sensitivity, specificity, accuracy, positive predictive value and negative predictive value. The measures of argumentation equality (CI) or difference (p-valor) are important to validate these indicators but do not indicate quality of screening.
conferenceObject Impact of Donor Age and Time on Mechanical Ventilation on Outcomes of Liver Transplantation in Brazil(2014) HADDAD, Luciana; CASSENOTE, Alex; OLIVEIRA, Cristina C.; ANDRAUS, Wellington; D'ALBUQUERQUE, Luiz Augusto Carneiro- Seroprevalence and Modifiable Risk Factors for Toxocara spp. in Brazilian Schoolchildren(2014) CASSENOTE, Alex J. F.; LIMA, Alba R. de Abreu; PINTO NETO, Jose M.; RUBINSKY-ELEFANT, GuitaBackground: Toxocariasis is a worldwide helminthic zoonosis caused by infection with the larvae of the ascarid worms that comprise the Toxocara spp. Children are particularly prone to infection because they are exposed to the eggs in sandboxes and playgrounds contaminated with dog and cat feces. Certain behaviors, such as a geophagy habit, poor personal hygiene, a lack of parental supervision, close contact with young dogs, and ingestion of raw meat, as well as gender, age, and socioeconomic status, affect the prevalence of the disease. However, previous studies of the risk factors for toxocariasis have generally produced inconsistent results. An epidemiological cross-sectional study was conducted to evaluate the seroprevalence of IgG anti-Toxocara spp. antibodies and associated factors in schoolchildren from a region in the southeast of Brazil. Methodology/Principal Findings: A total of 252 schoolchildren aged 1 to 12 years (120 males and 132 females) were assessed. An enzyme-linked immunosorbent assay based on Toxocara canis larval excretory-secretory antigens was used to determine outcomes. A questionnaire was used to collect information on children, family, and home characteristics. Clinical and laboratory data completed the dataset investigated in this study. Seroprevalence was 15.5% (95% CI 11.5-19.8). Geophagy (aPR 2.38 [95% CI 1.36-4.18], p-value 0.029) and the habit of hand washing before meals (aPR 0.04 [95% CI 0.01-0.11], p-value <= 0.001) were factors associated with increased and decreased seroprevalence, respectively. The income factor and its related variables lost statistical significance after adjustment with a multiple Poisson regression model. Conclusions/Significance: The current study confirms that toxocariasis is a public health problem in the evaluated area; modifiable factors such as soil contact and personal hygiene appear to have a greater influence on the acquisition of infection than sociodemographic attributes, thus representing direct targets for disease prevention and control.