CASSIO MACHADO DE CAMPOS BOTTINO
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Líder
11 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 11
- Metamemory and aging: Psychometric properties of the Brazilian version of the Multifactorial Memory Questionnaire for elderly(2016) SIMON, Sharon Sanz; ÁVILA, Renata Thomas; VIEIRA, Gilson; BOTTINO, Cássio Machado de CamposABSTRACT Metamemory measures provide subjective memory information and are relevant to investigate memory ability in aging. However, there is a lack of metamemory instruments available in Brazil. Objective: The aim of this study was to examine the psychometric properties of the Brazilian version of the Multifactorial Memory Questionnaire (MMQ), which evaluates different dimensions of subjective memory functioning, such as Feelings, Abilities and Strategies used in everyday life. Methods: The MMQ was translated into Portuguese and administered to 30 Brazilian elderly subjects. The participants underwent cognitive tests, mood scales and metamemory instruments. Results: Analyses revealed good internal consistency (Cronbach's a coefficient ranged from 0.75 to 0.89) and test-retest validity for each MMQ dimensions (positive correlations between two applications ranged from 0.75 to 0.8). Convergent validity evidence for the MMQ was confirmed by significant positive correlations (0.47 to 0.68) with dimensions of the Metamemory in Adulthood scale (MIA) (i.e., the Ability, Control, Self-efficacy and Strategy dimensions). Discriminant validity revealed no associations between the MMQ and cognitive performance, suggesting a weak metamemory-objective memory correspondence. Moreover, there was a negative correlation between MMQ-Ability subscale scores and mood symptoms (-0.63 for anxious symptoms, and -0.54 for depressive symptoms); and the Brazilian MMQ was comparable with MMQ translations to other languages. Conclusion: The Brazilian MMQ exhibits good psychometric properties and appears promising for clinical and research purposes. Additional studies are needed to further examine the psychometric properties of the Brazilian MMQ in a larger sample.
- The influence of lithium on hippocampal volume in elderly bipolar patients: a study using voxel-based morphometry(2016) ZUNG, S.; SOUZA-DURAN, F. L.; SOEIRO-DE-SOUZA, M. G.; UCHIDA, R.; BOTTINO, C. M.; BUSATTO, G. F.; VALLADA, H.Recent studies have demonstrated that lithium (Li) exerts neuronal protective and regenerative effects both in vitro and in vivo. However, the effects of long-term Li treatment in the brain areas associated with memory impairment of elderly bipolar patients are still unknown. The aim of this study was to compare the hippocampal volumes of elderly bipolar patients using Li, elderly bipolar patients not using Li and healthy controls. Sociodemographic, clinical and magnetic resonance imaging data from 30 elderly euthymic bipolar patients who had been using Li for an average of >61 months; 27 elderly euthymic bipolar patients not taking Li for an average of 45 months; and 22 elderly healthy controls were analyzed. Volumetric differences in the hippocampus between groups were investigated with voxel-based morphometry (VBM) based on the Statistical Parametric Mapping technique. No statistical differences in sociodemographic and clinical characteristics and course of bipolar disorder between the two bipolar groups were observed. Using small volume correction in the VBM analysis (analysis of variance (ANOVA)), one voxel cluster of statistical significance was detected in the left hippocampus (P<0.05 corrected for multiple comparisons, extent threshold >10 voxels). Post hoc unpaired t-tests revealed increased left hippocampal volume in the Li-treated group compared with the non-Li-treated group, and decreased left hippocampal volume in the non-Li group relative to controls. Additional exploratory two-group comparisons indicated trends toward reduced right-hippocampal volumes in the non-Li-treated group relative to both the Li-treated group and controls. The findings suggested that the use of Li may influence the volume of the hippocampus, possibly due to its neuroprotective effects.
- Normative data of Fuld Object Memory Evaluation test for brazilian elderly population(2016) AVILA, Renata; LOPES, Marcos Antonio; NAKANO, Eduardo Y.; BOTTINO, Cassio M. C.Objective: This study aims to present normative data for Fuld Object Memory Evaluation test stratified by sex, gender, age, and education for the Brazilian elderly population. Method: We evaluated 2.132 healthy elderly both genders, with a mean age of 70.30 years (+/- 7.28) from two community-based samples in Brazil drawn from different economic areas who were screened with cognitive and functional tests and the memory test. Statistical analyses were performed by independent t-test, one-way analysis of variance and multiple linear regression. Results: Statistical analyses showed that memory scores tend to improve significantly with increasing years of education and decrease significantly as age increased. Conclusion: We conclude that gender, education and age had effect on the Fuld Object Memory Evaluation performance in this Brazilian community-based sample.
- Frontal Lobe Degeneration in Adults with Down Syndrome and Alzheimer's Disease: A Review(2016) FONSECA, Luciana Mascarenhas; YOKOMIZO, Juliana Emy; BOTTINO, Cassio Machado; FUENTES, DanielBackground: There is a proven link between Down syndrome and the early development of the neuropathological features of Alzheimer's disease (AD). Changes in the personality and behavior of adults with Down syndrome might indicate the early stages of dementia or of frontotemporal lobar degeneration. The objective of this study was to investigate the executive functions and changes in behavior associated with frontal lobe degeneration in individuals with Down syndrome who develop AD. We conducted a systematic review selecting studies employing cognitive assessments. Summary: We identified few studies using objective measurements to determine whether cognitive aspects associated with the frontal lobe correlate with dementia in this population. We observed a tendency toward such correlations. (C) 2016 S. Karger AG, Basel
conferenceObject Cross-cultural Adaptation and Validity of the Brazilian version of the Clinical staging scale and disease progression in frontotemporal dementia(2016) SILVA, T. Bento Lima da; BAHIA, V.; CECCHINI, M. Amore; CASSIMIRO, L.; CARVALHO, V. Amaral; GUIMARAES, H. Cerqueira; CARAMELLI, P.; BALTHAZAR, M.; DAMASCENO, B.; BOTTINO, C.; BRUCKI, S.; SOUZA, L. Cruz de; MIOSHI, E.; NITRINI, R.; YASSUDA, M.- The Geriatric Anxiety Inventory in primary care: applicability and psychometric characteristics of the original and short form(2016) SILVA, Lais dos Santos Vinholi e; OLIVEIRA, Glaucia Martins de; YOKOMIZO, Juliana Emy; SARAN, Laura Ferreira; BOTTINO, Cassio Machado de Campos; YASSUDA, Monica SanchesBackground: Generalized anxiety disorder (GAD) has negative implications for people's lives, but is often underdiagnosed in the elderly. There is a shortage of instruments to assess geriatric anxiety. Objectives: To analyze the applicability and psychometric properties of the Portuguese version of the Geriatric Anxiety Inventory (GAI) and its short form (GAI-SF) within primary care. Methods: Fifty-five seniors were classified as non-demented by a multidisciplinary panel. The protocol included the GAI, the Self-Reporting Questionnaire (SRQ-20), the Depression Scale D-10, Mini-Mental State Examination (MMSE), Bayer Scale for Activities of Daily Living (B-ADL) and the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). A sub-sample also completed the Beck Anxiety Inventory (BAI). Results: The GAI and GAI-SF showed good internal consistency (0.89; 0.62, respectively) and test-retest stability (0.58, 0.97). The GAI and GAI-SF correlated significantly with the SRQ-20 (0.74, 0.55) and BAI (0.75, 0.58). Discussion: The psychometric characteristics of the Brazilian versions of the GAI and GAI-SF suggest these instruments are suitable for application in the Brazilian elderly population within the primary care setting.
bookPart Instrumentos de avaliação d uso em idosos(2016) BOTTINO, Cássio Machado de CamposconferenceObject Correlations between [18F]FDG-PET and Naa/mI spectroscopy data of the posterior cingulate cortex in amnestic mild cognitive impairment and Alzheimer's disease.(2016) COUTINHO, Artur; PORTO, Fabio; ZAMPIERI, Poliana; OTADUY, Maria; NUNES, Rafael; PERROCO, Tibor; BOTTINO, Cassio; ONO, Carla; LEITE, Claudia; BUCHPIGUEL, Carlos- Depression in Women with Recurrent Miscarriages - an Exploratory Study(2016) CARVALHO, Ariel Cesar de; SILVA, Michele Eugênio da; MATOS, Bárbara Magueta; BOTTINO, Cassio Machado de Campos; ABRAHÃO, Anelise Riedel; COHRS, Frederico Molina; BOTTINO, Sara Mota BorgesABSTRACT Objective: To assess depression, domestic violence and the use of substances in women with recurrent miscarriages. Methods: The Abuse Assessment Screen (AAS), the Edinburgh Postnatal Depression Scale (EPDS) and the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) were used to assess violence, depression and the use of substances among women with recurrent miscarriages. The population corresponded to patients receiv-ing prenatal care from June to August 2014. Multiple logistic regression was used to assess the multivariable relationship between depression and sociodemographic, psychosocial and medical characteristics (p < 0,10). Results: The prevalence of depression was of 41.3% (95% confidence interval [CI] 1/4 28.3-55.7%). One third of the pregnant women (32.6%) reported emotional or physical violence, and 13% were classified as abusing or addicted to tobacco according to ASSIST. History of psychiatric diseases was associated with depression (p 1/4 0.005). Violence during life demonstrated a modest association (p 1/4 0.073) with depression, as well as the number of miscarriages (p 1/4 0.071). Conclusion: Depression is a frequent disease among pregnant women with recurrent miscarriages. The results of this investigation suggest that a systematic assessment of depression and its associated conditions, such as domestic violence and the use of substances, should be part of the prenatal follow-up visits for women with recurrent miscarriages.
- The applicability of the cognitive abilities screening instrument-short (CASI-S) in primary care in Brazil(2016) OLIVEIRA, Glaucia Martins de; YOKOMIZO, Juliana Emy; SILVA, Lais dos Santos Vinholi e; SARAN, Laura Ferreira; BOTTINO, Cassio M. C.; YASSUDA, Monica SanchesBackground: The Cognitive Abilities Screening Instrument - Short (CASI-S) is a brief cognitive screening test. However, there is limited information regarding its applicability in primary care. Objectives: To ascertain whether the CASI-S differentiates between dementia patients and normal controls in primary care; to examine its correlation with other cognitive instruments, to analyze its internal consistency, test-retest stability, and diagnostic accuracy. Methods: In a case-control study, carried out at two Primary Care Units (PCUs) in the eastern region of the city of SAo Paulo, 47 older adults were diagnosed with dementia according to DSM-IV criteria (mean age = 76.81 7.03 years), and 55 were classified as normal controls (mean age = 72.78 7.37 years), by a multidisciplinary panel which had access to results from a comprehensive cognitive battery and the patients' health data. The present analyses included results from the Mini-Mental State Examination (MMSE). The CASI-S was not used to determine diagnostic status. Results: The CASI-S was easily applied in the primary care setting. There was a significant performance difference (p < 0.001) between dementia patients (15.57 +/- 7.40) and normal controls (26.67 +/- 3.52) on the CASI-S. CASI-S scores correlated with age ( = -0.410, p < 0.001), educational level ( = 0.373, p < 0.001), and MMSE score ( = 0.793, p < 0.001). The internal consistency of the CASI-S was high ( = 0.848) and the correlation between test and retest was 0.688, suggesting adequate temporal stability. In the ROC curve analyses, scores of 22/23 generated an area under the curve of 0.907, with sensitivity of 93% and specificity of 81%. Conclusions: The CASI-S can be useful for dementia screening in primary care in Brazil.