EDUARDO MASSAD
Projetos de Pesquisa
Unidades Organizacionais
Departamento de MedicinaLegal, Ética Médica e Medicina Social e do Trabalho, Faculdade de Medicina - Docente
LIM/01 - Laboratório de Informática Médica, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/01 - Laboratório de Informática Médica, Hospital das Clínicas, Faculdade de Medicina - Líder
6 resultados
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- Estimated Zika virus importations to Europe by travellers from Brazil(2016) MASSAD, Eduardo; TAN, Ser-Han; KHAN, Kamran; WILDER-SMITH, AnneliesBackground: Given the interconnectivity of Brazil with the rest of the world, Zika virus (ZIKV) infections have the potential to spread rapidly around the world via viremic travellers. The extent of spread depends on the travel volume and the endemicity in the exporting country. In the absence of reliable surveillance data, we did mathematical modelling to estimate the number of importations of ZIKV from Brazil into Europe. Design: We applied a previously developed mathematical model on importations of dengue to estimate the number of ZIKV importations into Europe, based on the travel volume, the probability of being infected at the time of travel, the population size of Brazil, and the estimated incidence of ZIKV infections. Results: Our model estimated between 508 and 1,778 imported infections into Europe in 2016, of which we would expect between 116 and 355 symptomatic Zika infections; with the highest number of importations being into France, Portugal and Italy. Conclusions: Our model identified high-risk countries in Europe. Such data can assist policymakers and public health professionals in estimating the extent of importations in order to prepare for the scale up of laboratory diagnostic assays and estimate the occurrence of Guillain-Barre Syndrome, potential sexual transmission, and infants with congenital ZIKV syndrome.
- ZikaPLAN: Zika Preparedness Latin American Network(2017) WILDER-SMITH, A.; PREET, R.; RENHORN, K. E.; XIMENES, R. A.; RODRIGUES, L. C.; SOLOMON, T.; NEYTS, J.; LAMBRECHTS, L.; WILLISON, H. J.; PEELING, R.; FALCONAR, A. K.; PRECIOSO, A. R.; LOGAN, J.; LANG, T.; ENDTZ, H. P.; MASSAD, E.The ongoing Zika virus (ZIKV) outbreak in Latin America, the Caribbean, and the Pacific Islands has underlined the need for a coordinated research network across the whole region that can respond rapidly to address the current knowledge gaps in Zika and enhance research preparedness beyond Zika. The European Union under its Horizon 2020 Research and Innovation Programme awarded three research consortia to respond to this need. Here we present the ZikaPLAN (Zika Preparedness Latin American Network) consortium. ZikaPLAN combines the strengths of 25 partners in Latin America, North America, Africa, Asia, and various centers in Europe. We will conduct clinical studies to estimate the risk and further define the full spectrum and risk factors of congenital Zika virus syndrome (including neurodevelopmental milestones in the first 3 years of life), delineate neurological complications associated with ZIKV due to direct neuroinvasion and immune-mediated responses in older children and adults, and strengthen surveillance for birth defects and Guillain-Barre Syndrome. Laboratory-based research to unravel neurotropism and investigate the role of sexual transmission, determinants of severe disease, and viral fitness will underpin the clinical studies. Social messaging and engagement with affected communities, as well as development of wearable repellent technologies against Aedes mosquitoes will enhance the impact. Burden of disease studies, data-driven vector control, and vaccine modeling as well as risk assessments on geographic spread of ZIKV will form the foundation for evidence-informed policies. While addressing the research gaps around ZIKV, we will engage in capacity building in laboratory and clinical research, collaborate with existing and new networks to share knowledge, and work with international organizations to tackle regulatory and other bottlenecks and refine research priorities. In this way, we can leverage the ZIKV response toward building a long-term emerging infectious diseases response capacity in the region to address future challenges.
- DengueTools: innovative tools and strategies for the surveillance and control of dengue(2012) WILDER-SMITH, Annelies; RENHORN, Karl-Erik; TISSERA, Hasitha; BAKAR, Sazaly Abu; ALPHEY, Luke; KITTAYAPONG, Pattamaporn; LINDSAY, Steve; LOGAN, James; HATZ, Christoph; REITER, Paul; ROCKLOV, Joacim; BYASS, Peter; LOUIS, Valerie R.; TOZAN, Yesim; MASSAD, Eduardo; TENORIO, Antonio; LAGNEAU, Christophe; L'AMBERT, Gregory; BROOKS, David; WEGERDT, Johannah; GUBLER, DuaneDengue fever is a mosquito-borne viral disease estimated to cause about 230 million infections worldwide every year, of which 25,000 are fatal. Global incidence has risen rapidly in recent decades with some 3.6 billion people, over half of the world's population, now at risk, mainly in urban centres of the tropics and subtropics. Demographic and societal changes, in particular urbanization, globalization, and increased international travel, are major contributors to the rise in incidence and geographic expansion of dengue infections. Major research gaps continue to hamper the control of dengue. The European Commission launched a call under the 7th Framework Programme with the title of 'Comprehensive control of Dengue fever under changing climatic conditions'. Fourteen partners from several countries in Europe, Asia, and South America formed a consortium named 'DengueTools' to respond to the call to achieve better diagnosis, surveillance, prevention, and predictive models and improve our understanding of the spread of dengue to previously uninfected regions (including Europe) in the context of globalization and climate change. The consortium comprises 12 work packages to address a set of research questions in three areas: Research area 1: Develop a comprehensive early warning and surveillance system that has predictive capability for epidemic dengue and benefits from novel tools for laboratory diagnosis and vector monitoring. Research area 2: Develop novel strategies to prevent dengue in children. Research area 3: Understand and predict the risk of global spread of dengue, in particular the risk of introduction and establishment in Europe, within the context of parameters of vectorial capacity, global mobility, and climate change. In this paper, we report on the rationale and specific study objectives of 'DengueTools'. DengueTools is funded under the Health theme of the Seventh Framework Programme of the European Community, Grant Agreement Number: 282589 Dengue Tools.
- The legacy of ZikaPLAN: a transnational research consortium addressing Zika(2021) WILDER-SMITH, Annelies; BRICKLEY, Elizabeth B.; XIMENES, Ricardo Arraes de Alencar; MIRANDA-FILHO, Democrito de Barros; MARTELLI, Celina Maria Turchi; SOLOMON, Tom; JACOBS, Bart C.; PARDO, Carlos A.; OSORIO, Lyda; PARRA, Beatriz; LANT, Suzannah; WILLISON, Hugh J.; LEONHARD, Sonja; TURTLE, Lance; FERREIRA, Maria Lucia Brito; FRANCA, Rafael Freitas de Oliveira; LAMBRECHTS, Louis; NEYTS, Johan; KAPTEIN, Suzanne; PEELING, Rosanna; BOERAS, Deborah; LOGAN, James; DOLK, Helen; ORIOLI, Ieda M.; NEUMAYR, Andreas; LANG, Trudie; BAKER, Bonny; MASSAD, Eduardo; PREET, RamanGlobal health research partnerships with institutions from high-income countries and low- and middle-income countries are one of the European Commission's flagship programmes. Here, we report on the ZikaPLAN research consortium funded by the European Commission with the primary goal of addressing the urgent knowledge gaps related to the Zika epidemic and the secondary goal of building up research capacity and establishing a Latin American-European research network for emerging vector-borne diseases. Five years of collaborative research effort have led to a better understanding of the full clinical spectrum of congenital Zika syndrome in children and the neurological complications of Zika virus infections in adults and helped explore the origins and trajectory of Zika virus transmission. Individual-level data from ZikaPLAN`s cohort studies were shared for joint analyses as part of the Zika Brazilian Cohorts Consortium, the European Commission-funded Zika Cohorts Vertical Transmission Study Group, and the World Health Organization-led Zika Virus Individual Participant Data Consortium. Furthermore, the legacy of ZikaPLAN includes new tools for birth defect surveillance and a Latin American birth defect surveillance network, an enhanced Guillain-Barre Syndrome research collaboration, a de-centralized evaluation platform for diagnostic assays, a global vector control hub, and the REDe network with freely available training resources to enhance global research capacity in vector-borne diseases.
- ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas(2019) WILDER-SMITH, Annelies; PREET, Raman; BRICKLEY, Elizabeth B.; XIMENES, Ricardo Arraes de Alencar; MIRANDA-FILHO, Democrito de Barros; MARTELLI, Celina Maria Turchi; ARAUJO, Thalia Velho Barreto de; MONTARROYOS, Ulisses Ramos; MOREIRA, Maria Elisabeth; TURCHI, Marilia Dalva; SOLOMON, Tom; JACOBS, Bart C.; VILLAMIZAR, Carlos Pardo; OSORIO, Lyda; FILIPPS, Ana Maria Bispo de; NEYTS, Johan; KAPTEIN, Suzanne; HUITS, Ralph; ARIEN, Kevin K.; WILLISON, Hugh J.; EDGAR, Julia M.; BARNETT, Susan C.; PEELING, Rosanna; BOERAS, Debi; GUZMAN, Maria G.; SILVA, Aravinda M. de; FALCONAR, Andrew K.; ROMERO-VIVAS, Claudia; GAUNT, Michael W.; SETTE, Alessandro; WEISKOPF, Daniela; LAMBRECHTS, Louis; DOLK, Helen; MORRIS, Joan K.; ORIOLI, Ieda M.; O'REILLY, Kathleen M.; YAKOB, Laith; ROCKLOV, Joacim; SOARES, Cristiane; FERREIRA, Maria Lucia Brito; FRANCA, Rafael Freitas de Oliveira; PRECIOSO, Alexander R.; LOGAN, James; LANG, Trudie; JAMIESON, Nina; MASSAD, EduardoZika Preparedness Latin American Network (ZikaPLAN) is a research consortium funded by the European Commission to address the research gaps in combating Zika and to establish a sustainable network with research capacity building in the Americas. Here we present a report on ZikaPLAN`s mid-term achievements since its initiation in October 2016 to June 2019, illustrating the research objectives of the 15 work packages ranging from virology, diagnostics, entomology and vector control, modelling to clinical cohort studies in pregnant women and neonates, as well as studies on the neurological complications of Zika infections in adolescents and adults. For example, the Neuroviruses Emerging in the Americas Study (NEAS) has set up more than 10 clinical sites in Colombia. Through the Butantan Phase 3 dengue vaccine trial, we have access to samples of 17,000 subjects in 14 different geographic locations in Brazil. To address the lack of access to clinical samples for diagnostic evaluation, ZikaPLAN set up a network of quality sites with access to well-characterized clinical specimens and capacity for independent evaluations. The International Committee for Congenital Anomaly Surveillance Tools was formed with global representation from regional networks conducting birth defects surveillance. We have collated a comprehensive inventory of resources and tools for birth defects surveillance, and developed an App for low resource regions facilitating the coding and description of all major externally visible congenital anomalies including congenital Zika syndrome. Research Capacity Network (REDe) is a shared and open resource centre where researchers and health workers can access tools, resources and support, enabling better and more research in the region. Addressing the gap in research capacity in LMICs is pivotal in ensuring broad-based systems to be prepared for the next outbreak. Our shared and open research space through REDe will be used to maximize the transfer of research into practice by summarizing the research output and by hosting the tools, resources, guidance and recommendations generated by these studies. Leveraging on the research from this consortium, we are working towards a research preparedness network.
- Theoretical impact of insecticide-impregnated school uniforms on dengue incidence in Thai children(2013) MASSAD, Eduardo; AMAKU, Marcos; COUTINHO, Francisco Antonio Bezerra; KITTAYAPONG, Pattamaporn; WILDER-SMITH, AnneliesBackground: Children carry the main burden of morbidity and mortality caused by dengue. Children spend a considerable amount of their day at school; hence strategies that reduce human-mosquito contact to protect against the day-biting habits of Aedes mosquitoes at schools, such as insecticide-impregnated uniforms, could be an effective prevention strategy. Methodology: We used mathematical models to calculate the risk of dengue infection based on force of infection taking into account the estimated proportion of mosquito bites that occur in school and the proportion of school time that children wear the impregnated uniforms. Principal findings: The use of insecticide-impregnated uniforms has efficacy varying from around 6% in the most pessimistic estimations, to 55% in the most optimistic scenarios simulated. Conclusions: Reducing contact between mosquito bites and human hosts via insecticide-treated uniforms during school time is theoretically effective in reducing dengue incidence and may be a valuable additional tool for dengue control in school-aged children. The efficacy of this strategy, however, is dependent on the compliance of the target population in terms of proper and consistent wearing of uniforms and, perhaps more importantly, the proportion of bites inflicted by the Aedes population during school time.