LUIS AUGUSTO PALMA DALLAN

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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina

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Autor e Coautores FMUSP-HC Normalizados: MUCIO TAVARES DE OLIVEIRA JUNIOR ×

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Agora exibindo 1 - 7 de 7
  • article 0 Citação(ões) na Scopus
    Endovascular therapeutic hypothermia adjunctive to percutaneous coronary intervention in acute myocardial infarction: realistic simulation as a game changer
    (2022) DALLAN, Luis Augusto Palma; DAE, Michael; GIANNETTI, Natali Schiavo; POLASTRI, Tathiane Facholi; LIMA, Marian Keiko Frossard; ROCHITTE, Carlos Eduardo; HAJJAR, Ludhmila Abrahao; MARTIN, Claudia Yanet Bernoche San; LIMA, Felipe Gallego; NICOLAU, Jose Carlos; JR, Mucio Tavares de Oliveira; DALLAN, Luis Alberto Oliveira; SILVA, Expedito Eustaquio Ribeiro da; FILHO, Roberto Kalil; ABIZAID, Alexandre; LEMOS NETO, Pedro Alves; TIMERMAN, Sergio
    Background: Endovascular therapeutic hypothermia (ETH) reduces the damage by ischemia/reperfusion cell syndrome in cardiac arrest and has been studied as an adjuvant therapy to percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI). New available advanced technology allows cooling much faster, but there is paucity of resources for training to avoid delays in door-to-balloon time (DTB) due to ETU and subsequently coronary reperfusion, which would derail the procedure. The aim of the study was to describe the process for the development of a simulation, training & educational protocol for the multidisciplinary team to perform optimized ETH as an adjunctive therapy for STEMI. Methods and results: We developed an optimized simulation protocol using modern mannequins in different realistic scenarios for the treatment of patients undergoing ETH adjunctive to PCI for STEN s starting from the emergency room, through the CathLab, and to the intensive care unit (ICU) using the Proteus (R) Endovascular System (loll Circulation Inc (TM), San Jose, CA, USA). The primary endpoint was door-to-balloon (DTB) time. We successfully trained 361 multidisciplinary professionals in realistic simulation using modern mannequins and sham situations in divisions of the hospital where real patients would be treated. The focus of simulation and training was logistical optimization and educational debriefing with strategies to reduce waste of time in patient's transportation from different departments, and avoiding excessive rewanning during transfer. Afterwards, the EHT protocol was successfully validated in a trial randomizing 50 patients for 18 minutes cooling before coronary recanalization at the target temperature of 32 +/- 1.0 degrees C or PCI-only. A total of 35 patients underwent FM (85.7% [30/35] in 90 +/- 15 minutes), without delays in the mean door-to-balloon time for primary PCI when compared to 15 control group patients (92.1 minutes versus 87 minutes, respectively; p = 0.509). Conclusions: Realistic simulation, intensive training and educational debriefing for the multidisciplinary team propitiated feasible endovascular therapeutic hypothermia as an adjuvant therapy to primary PCI in STEM.
  • conferenceObject
    Training, Simulation and Validation of Therapeutic Hypothermia as an Adjuvant Treatment in St Segment Elevation Myocardial Infarction
    (2018) DALLAN, Luis Augusto; RIBEIRO, Marcelo; GIANNETTI, Natali; ROCHITTE, Carlos; NOMURA, Cesar H.; HAJJAR, Ludhmila A.; BERNOCHE, Claudia Y.; LAGE, Silvia G.; NICOLAU, Jose Carlos; OLIVEIRA, Mucio T.; POLASTRI, Thatiane F.; RIBEIRO, Expedito E.; KALIL FILHO, Roberto; LEMOS NETO, Pedro A.; TIMERMAN, Sergio
  • article 9 Citação(ões) na Scopus
    Cooling as an Adjunctive Therapy to Percutaneous Intervention in Acute Myocardial Infarction: COOL-MI InCor Trial
    (2021) DALLAN, Luis Augusto Palma; GIANNETTI, Natali Schiavo; ROCHITTE, Carlos Eduardo; POLASTRI, Thatiane Facholi; MARTIN, Claudia Yanet Bernoche San; HAJJAR, Ludhmila Abrahao; NICOLAU, Jose Carlos; JR, Mucio Tavares de Oliveira; DAE, Michael; SILVA, Expedito Eustaquio Ribeiro da; KALIL FILHO, Roberto; LEMOS, Pedro Alves; TIMERMAN, Sergio
    Endovascular Therapeutic hypothermia (ETH) reduces the damage caused by postischemia reperfusion injury syndrome in cardiopulmonary arrest and has already established its role in patients with sudden death; however, its role in ST-segment elevation myocardial infarction (STEMI) remains controversial. The objectives of this study were to investigate the safety, feasibility, and 30-day efficacy of rapid induction of therapeutic hypothermia as adjunctive therapy to percutaneous coronary intervention (PCI) in patients with anterior and inferior STEMIs. This was a prospective, controlled, randomized, two-arm, prospective, interventional study of patients admitted to the emergency department within 6 hours of angina onset, with anterior or inferior STEMI eligible for PCI. Subjects were randomized to the hypothermia group (primary PCI+ETH) or to the control group (primary PCI) at a 4:1 ratio. The ETH was induced by 1 L cold saline (1-4 degrees C) associated with the Proteus (TM) System, by cooling for at least 18 minutes before coronary reperfusion with a target temperature of 32 degrees C +/- 1 degrees C. Maintenance of ETH was conducted for 1-3 hours, and active reheating was done at a rate of 1 degrees C/h for 4 hours. Primary safety outcomes were the feasibility of ETH in the absence of (1) door-to-balloon (DTB) delay; (2) major adverse cardiac events (MACE) within 30 days after randomization. The primary outcomes of effectiveness were infarct size (IS) and left ventricular ejection fraction (LVEF) at 30 days. An as-treated statistical analysis was performed. Fifty patients were included: 35 (70%) randomized to the hypothermia group and 15 (30%) to the control group. The mean age was 58 +/- 12 years; 78% were men; and associated diseases were 60% hypertension, 42% diabetes, and 72% dyslipidemia. The compromised myocardial wall was anterior in 38% and inferior in 62%, and the culprit vessels were left anterior descending artery (LAD) (40%), right coronary artery (38%), and left circumflex (18%). All 35 patients who attempted ETH (100%) had successful cooling, with a mean endovascular coronary reperfusion temperature of 33.1 degrees C +/- 0.9 degrees C. The mean ischemic time was 375 +/- 89.4 minutes in the hypothermia group and 359.5 +/- 99.4 minutes in the control group. The mean DTB was 92.1 +/- 20.5 minutes in the hypothermia group and 87 +/- 24.4 minutes in the control group. The absolute difference of 5.1 minutes was not statistically significant (p = 0.509). The MACE rates were similar between both groups (21.7% vs. 20% respectively,p = 0.237). In the comparison between the hypothermia and control groups, no statistically significant differences were observed at 30 days between mean IS (13.9% +/- 8% vs. 13.8% +/- 10.8%, respectively,p = 0.801) and mean final LVEF (43.3% +/- 11.2% vs. 48.3 +/- 10.9%, respectively;p = 0.194). Hypothermia as an adjunctive therapy to primary PCI in STEMI is feasible and can be implemented without delay in coronary reperfusion. Hypothermia was safe regarding the incidence of MACE at 30 days. However, there was a higher incidence of arrhythmia and in-hospital infection in the hypothermia group, with no increase in mortality. Regarding efficacy, there was no difference in IS or LVEF at 30 days that would suggest additional myocardial protection with ETH.ClinicalTrials.gov:NCT02664194.
  • article 0 Citação(ões) na Scopus
    I Diretriz de ressuscitação cardiopulmonar e cuidados cardiovasculares de emergência da Sociedade Brasileira de Cardiologia
    (2013) GONZALEZ, M. M.; TIMERMAN, S.; GIANOTTO-OLIVEIRA, R.; POLASTRI, T. F.; CANESIN, M. F.; SCHIMIDT, A.; SIQUEIRA, A. W.; PISPICO, A.; LONGO, A.; PIERI, A.; REIS, A.; TANAKA, A. C. S.; SANTOS, A. M.; QUILICI, A. P.; RIBEIRO, A. C. L.; BARRETO, A. C. P.; PAZIN-FILHO, A.; TIMERMAN, A.; MACHADO, C. A.; FRANCHIN NETO, C.; MIRANDA, C. H.; MEDEIROS, C. R.; MALAQUE, C. M. S.; BERNOCHE, C.; GONCALVES, D. M.; SANT'ANA, D. G.; OSAWA, E. A.; PEIXOTO, E.; ARFELLI, E.; EVARISTO, E. F.; AZEKA, E.; GOMES, E. P.; WEN, F. H.; FERREIRA, F. G.; LIMA, F. G.; MATTOS, F. R.; GALAS, F. G.; MARQUES, F. R. B.; TARASOUTCHI, F.; MANCUSO, F. J. N.; FREITAS, G. R.; FEITOSA-FILHO, G. S.; BARBOSA, G. C.; GIOVANINI, G. R.; MIOTTO, H. C.; GUIMARAES, H. P.; ANDRADE, J. P.; OLIVEIRA-FILHO, J.; FERNANDES, J. G.; MORAES JUNIOR, J. B. M. X.; CARVALHO, J. J. F.; RAMIRES, J. A. F.; CAVALINI, J. F.; TELES, J. M. M.; LOPES, J. L.; LOPES, L. N. G. D.; PIEGAS, L. S.; HAJJAR, L. A.; BRUNORIO, L.; DALLAN, L. A. P.; CARDOSO, L. F.; RABELO, M. M. N.; ALMEIDA, M. F. B.; SOUZA, M. F. S.; FAVARATO, M. H.; PAVAO, M. L. R. C.; SHIMODA, M. S.; OLIVEIRA JUNIOR, M. T.; MIURA, N.; FILGUEIRAS FILHO, N. M.; PONTES-NETO, O. M.; PINHEIRO, P. A. P. C.; FARSKY, O. S.; LOPES, R. D.; SILVA, R. C. G.; KALIL FILHO, R.; GONCALVES, R. M.; GAGLIARDI, R. J.; GUINSBURG, R.; LISAK, S.; ARAUJO, S.; MARTINS, S. C. O.; LAGE, S. G.; FRANCHI, S. M.; SHIMODA, T.; ACCORSI, T. D.; BARRAL, T. C. N.; MACHADO, T. A. O.; SCUDELER, T. L.; LIMA, V. C.; GUIMARAES, V. A.; SALLAI, V. S.; XAVIER, W. S.; NAZIMA, W.; SAKO, Y. K.
  • article 30 Citação(ões) na Scopus
    Brazilian Society of Cardiology Guidelines on Unstable Angina and Acute Myocardial Infarction without ST-Segment Elevation-2021
    (2021) NICOLAU, Jose Carlos; FEITOSA FILHO, Gilson Soares; PETRIZ, Joao Luiz; FURTADO, Remo Holanda de Mendonca; PRECOMA, Dalton Bertolim; LEMKE, Walmor; LOPES, Renato Delascio; TIMERMAN, Ari; MARIN-NETO, Jose A.; NETO, Luiz Bezerra; GOMES, Bruno Ferraz de Oliveira; SANTOS, Eduardo Cavalcanti Lapa; PIEGAS, Leopoldo Soares; SOEIRO, Alexandre de Matos; NEGRI, Alexandre Jorge de Andrade; FRANCI, Andre; MARKMAN FILHO, Brivaldo; BACCARO, Bruno Mendonca; MONTENEGRO, Carlos Eduardo Lucena; ROCHITTE, Carlos Eduardo; BARBOSA, Carlos Jose Dornas Goncalves; VIRGENS, Claudio Marcelo Bittencourt das; STEFANINI, Edson; MANENTI, Euler Roberto Fernandes; LIMA, Felipe Gallego; MONTEIRO JUNIOR, Francisco das Chagas; CORREA FILHO, Harry; PENA, Henrique Patrus Mundim; PINTO, Ibraim Masciarelli Francisco; FALCAO, Joao Luiz de Alencar Araripe; SENA, Joberto Pinheiro; PEIXOTO, Jose Maria; SOUZA, Juliana Ascencao de; SILVA, Leonardo Sara da; MAIA, Lilia Nigro; OHE, Louis Nakayama; BARACIOLI, Luciano Moreira; DALLAN, Luis Alberto de Oliveira; DALLAN, Luis Augusto Palma; MATTOS, Luiz Alberto Piva e; BODANESE, Luiz Carlos; RITT, Luiz Eduardo Fonteles; CANESIN, Manoel Fernandes; RIVAS, Marcelo Bueno da Silva; FRANKEN, Marcelo; MAGALHAES, Marcos Jose Gomes; OLIVEIRA JUNIOR, Mucio Tavares de; FILGUEIRAS FILHO, Nivaldo Menezes; DUTRA, Oscar Pereira; COELHO, Otavio Rizzi; LEAES, Paulo Ernesto; ROSSI, Paulo Roberto Ferreira; SOARES, Paulo Rogerio; LEMOS NETO, Pedro Alves; FARSKY, Pedro Silvio; CAVALCANTI, Rafael Rebelo C.; ALVES, Renato Jorge; KALIL, Renato Abdala Karam; ESPORCATTE, Roberto; MARINO, Roberto Luiz; GIRALDEZ, Roberto Rocha Correa Veiga; MENEGHELO, Romeu Sergio; LIMA, Ronaldo de Souza Leao; RAMOS, Rui Fernando; FALCAO, Sandra Nivea dos Reis Saraiva; DALCOQUIO, Talia Falcao; LEMKE, Viviana de Mello Guzzo; CHALELA, William Azem; MATHIAS JUNIOR, Wilson
  • conferenceObject
    Cold Saline Versus Regular Saline in Endovascular Therapeutic Hypothermia in Acute ST Segment Elevation Myocardial infarction
    (2020) DALLAN, Luis; DAE, Michael; GIANNETTI, Natali; POLASTRI, Thatiane Facholi; ROCHITTE, Carlos; NOMURA, Cesar; HAJJAR, Ludhmila Abrahao; BERNOCHE, Claudia; LAGE, Silvia; LIMA, Felipe Gallego; OLIVEIRA, Mucio Tavares; KERN, Karl; NICOLAU, Jose Carlos; RIBEIRO, Expedito; KALIL, Roberto; NETO, Pedro Lemos; TIMERMAN, Sergio
  • article 30 Citação(ões) na Scopus
    Update on the Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Guideline of the Brazilian Society of Cardiology-2019
    (2019) BERNOCHE, Claudia; TIMERMAN, Sergio; POLASTRI, Thatiane Facholi; GIANNETTI, Natali Schiavo; SIQUEIRA, Adailson Wagner da Silva; PISCOPO, Agnaldo; SOEIRO, Alexandre de Matos; REIS, Amelia Gorete Afonso da Costa; TANAKA, Ana Cristina Sayuri; THOMAZ, Ana Maria; QUILICI, Ana Paula; CATARINO, Andrei Hilario; RIBEIRO, Anna Christina de Lima; BARRETO, Antonio Carlos Pereira; AZEVEDO FILHO, Antonio Fernando Barros de; PAZIN FILHO, Antonio; TIMERMAN, Ari; SCARPA, Bruna Romanelli; TIMERMAN, Bruno; TAVARES, Caio de Assis Moura; MARTINS, Cantidio Soares Lemos; SERRANO JUNIOR, Carlos Vicente; MALAQUE, Ceila Maria Sant'Ana; PISANI, Cristiano Faria; BATISTA, Daniel Valente; LEANDRO, Daniela Luana Fernandes; SZPILMAN, David; GONCALVES, Diego Manoel; PAIVA, Edison Ferreira de; OSAWA, Eduardo Atsushi; LIMA, Eduardo Gomes; ADAM, Eduardo Leal; PEIXOTO, Elaine; EVARISTO, Eli Faria; AZEKA, Estela; SILVA, Fabio Bruno da; WEN, Fan Hui; FERREIRA, Fatima Gil; LIMA, Felipe Gallego; FERNANDES, Felipe Lourenco; GANEM, Fernando; GALAS, Filomena Regina Barbosa Gomes; TARASOUTCHI, Flavio; SOUZA, Germano Emilio Conceicao; FEITOSA FILHO, Gilson Soares; FORONDA, Gustavo; GUIMARAES, Helio Penna; ABUD, Isabela Cristina Kirnew; LEITE, Ivanhoe Stuart Lima; LINHARES FILHO, Jaime Paula Pessoa; MORAES JUNIOR, Joao Batista de Moura Xavier; FALCAO, Joao Luiz Alencar de Araripe; RAMIRES, Jose Antonio Franchini; CAVALINI, Jose Fernando; SARAIVA, Jose Francisco Kerr; ABRAO, Karen Cristine; PINTO, Lecio Figueira; BIANCHI, Leonardo Luis Torres; LOPES, Leonardo Nicolau Geisler Daud; PIEGAS, Leopoldo Soares; KOPEL, Liliane; GODOY, Lucas Colombo; TOBASE, Lucia; HAJJAR, Ludhmila Abrahao; DALLAN, Luis Augusto Palma; CANEO, Luiz Fernando; CARDOSO, Luiz Francisco; CANESIN, Manoel Fernandes; PARK, Marcelo; RABELO, Marcia Maria Noya; MALACHIAS, Marcus Vinicius Bolivar; GONCALVES, Maria Aparecida Batistao; ALMEIDA, Maria Fernanda Branco de; SOUZA, Maria Francilene Silva; FAVARATO, Maria Helena Sampaio; CARRION, Maria Julia Machline; GONZALEZ, Maria Margarita; BORTOLOTTO, Maria Rita de Figueiredo Lemos; MACATRAO-COSTA, Milena Frota; SHIMODA, Monica Satsuki; OLIVEIRA-JUNIOR, Mucio Tavares de; IKARI, Nana Miura; DUTRA, Oscar Pereira; BERWANGER, Otavio; PINHEIRO, Patricia Ana Paiva Correa; REIS, Patricia Feitosa Frota dos; CELLIA, Pedro Henrique Moraes; SANTOS FILHO, Raul Dias dos; GIANOTTO-OLIVEIRA, Renan; KALIL FILHO, Roberto; GUINSBURG, Ruth; MANAGINI, Sandrigo; LAGE, Silvia Helena Gelas; YEU, So Pei; FRANCHI, Sonia Meiken; SHIMODA-SAKANO, Tania; ACCORSI, Tarso Duenhas; LEAL, Tatiana de Carvalho Andreucci; GUIMARAES, Vanessa; SALLAI, Vanessa Santos; AVILA, Walkiria Samuel; SAKO, Yara Kimiko