TAN CHEN WU
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- First-Degree Atrioventricular Block: A Finding Not Always Benign!(2022) WU, Tan Chen
- Trombo Atrial Esquerdo e Contraste Espontaneo Denso no Uso de Anticoagulante Oral de Acao Direta em Fibrilacao Atrial: Visao de Centro Referenciado(2022) MARQUES, Thiago; DARRIEUX, Francisco; GOUVEA, Fabio; GARAMBONE, Leandro; LINDOSO, Ana Paula; LAGE, Joao; SACILOTTO, Luciana; COIMBRA, Ana Lucia; PINHEIRO, Martina; OLIVETTI, Natalia; LARA, Sissy; HARDY, Carina; ATHAYDE, Guilherme; HACHUL, Denise; PISANI, Cristiano; WU, Tan Chen; SCANAVACCA, MauricioBackground: In the treatment of atrial fibrillation (AF), the most frequently sustained arrhythmia, with catheter ablation (CA) or electrical cardioversion (ECV), the periprocedural period is one of the most critical phases. Currently, the use of new direct action oral anticoagulants (DOAC) is increasingly frequent; however, in the real world, there are still few data on studies on the thrombus incidence in the left atrium (TrLA) or dense spontaneous contrast (DSC) on transesophageal echocardiogram (TEE). Objective: To evaluate the prevalence of events and association with risk factors in patients using DOACs. Primary objective: to analyze the prevalence of thrombus in the LA by TEE in patients using DOAC undergoing ECV/CA. Second, evaluate the association of comorbidities with the presence of thrombi and DSC. Methods: Retrospective cohort, single-center study with patients followed at the Arrhythmia Outpatient Unit (InCor-HCFMUSP). Patients indicated for procedures and using DOACs were selected, and their clinical/echocardiographic data were analyzed. A significance level of 5% was considered. Results: 354 patients were included, a total of 400 procedures, from March 2012-March 2018. Thrombus in the LA was found in 11 patients (2.8%), associated with advanced age (p=0.007) and higher CHA2DS2-VASc (p<0.001) score. DSC in the LA before TEE was found in 29 patients (7.3%), with lower LVEF (p<0.038) and greater LA dimension (p<0.0001). Conclusion: The incidence of LA thrombus and DSC in patients using DOC in the context of AF ECV/CA, although small, is not negligible. Patients with higher CHA2DS2-VASc scores, especially older and with larger LA diameter, are more prone to these echocardiographic findings.
bookPart Bradiarritmias(2022) TEIXEIRA, Amanda Ferino; LANDIM, Felipe Bringel; WU, Tan Chen- Measuring Human Perception of Biophilically-Driven Design with Facial Micro-expressions Analysis and EEG Biosensor(2022) MACRUZ, Andrea; BUENO, Ernesto; PALMA, Gustavo G.; VEGA, Jaime; PALMIERI, Ricardo A.; WU, Tan ChenThis paper investigates the role technology and neuroscience play in aiding the design process and making meaningful connections between people and nature. Using two workshops as a vehicle, the team introduced advanced technologies and Quantified Self practices that allowed people to use neural data and pattern recognition as feedback for the design process. The objective is to find clues to natural elements of human perception that can inform the design to meet goals for well-being. A pattern network of geometric shapes that achieve a higher level of monitored meditation levels and point toward a positive emotional valence is proposed. By referencing biological forms found in nature, the workshops utilized an algorithmic process that explored how nature can influence architecture. To measure the impact, the team used FaceOSC for capture and an Artificial Neural Network for micro-expression recognition, and a MindWave sensor manufactured by NeuroSky, which documented the human response further. The methodology allowed us to establish a boundary logic, ranking geometric shapes that suggested positive emotions and a higher level of monitored meditation levels. The results pointed us to a deeper level of understanding relative to geometric shapes in design. They indicate a new way to predict how well-being factors can clarify and rationalize a more intuitive design process inspired by nature.
- Effect of Occurrence of Lamin A/C (LMNA) Genetic Variants in a Cohort of 101 Consecutive Apparent ""Lone AF"" Patients: Results and Insights(2022) PESSENTE, Gabrielle D'Arezzo; SACILOTTO, Luciana; CALIL, Zaine Oliveira; OLIVETTI, Natalia Quintella Sangiorgi; WULKAN, Fanny; OLIVEIRA, Theo Gremen Mimary de; PEDROSA, Anisio Alexandre Andrade; WU, Tan Chen; HACHUL, Denise Tessariol; SCANAVACCA, Mauricio Ibrahim; KRIEGER, Jose Eduardo; DARRIEUX, Francisco Carlos da Costa; PEREIRA, Alexandre da CostaObjectiveMutations in the Lamin A/C (LMNA) gene are commonly associated with cardiac manifestations, such as dilated cardiomyopathy (DCM) and conduction system disease. However, the overall spectrum and penetrance of rare LMNA variants are unknown. The present study described the presence of LMNA variants in patients with ""lone atrial fibrillation (AF)"" as their sole clinical presentation. MethodsOne-hundred and one consecutive patients with ""lone AF"" criteria were initially screened by genetic testing. Genetic variants were classified according to the American College of Genetic and Genomic criteria. All subjects were evaluated through clinical and familial history, ECG, 24-h Holter monitoring, echocardiogram, cardiac magnetic resonance, treatment response, and the present relatives of LMNA carriers. In addition, whole-exome data from 49,960 UK Biobank (UKB) participants were analyzed to describe the overall penetrance of rare LMNA missense and loss of function (LOF) variants. ResultsThree missense variants in LMNA were identified in probands with AF as their first and unique clinical manifestation. Other five first-degree relatives, after the screening, also presented LMNA gene variants. Among 49,960 analyzed UKB participants, 331 carried rare LMNA missense or LOF variant. Participants who carried a rare LMNA variant were significantly associated with higher odds of arrhythmic events and of an abnormal ECG in the per-protocol ECG exam (p = 0.03 and p = 0.05, respectively). ConclusionAlthough a rare occurrence, our findings emphasize the possibility of an initial presentation of apparently ""lone AF"" in LMNA gene variant carriers.
- Sinus Node Artery Occlusion During Cardiac Denervation Procedures(2022) SCANAVACCA, M.; RIVAROLA, E. W. R.; TORRES, R. V. A.; HARDY, C.; WU, T. C.; DARRIEUX, F.; PISANI, C.; HACHUL, D.Cardioneural ablation is a novel treatment for functional bradycardia. However, the risk of acute complications is still unknown. The aim of this case report is to describe acute occlusion of the sinus node artery after cardiac denervation procedures in 2 patients and to encourage measures to prevent it, such as evaluating the aortic angulation in older patients before the procedure and by monitoring signs of sinus failure during ablation in patients with electroanatomical maps showing a constricted aspect of the right atrium. (Level of Difficulty: Advanced.) © 2022 The Authors