TAMARA PESSANHA TAPOROSKI
Projetos de Pesquisa
Unidades Organizacionais
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
13 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 13
- IDENTIFICATION OF NOVEL GWAS HITS FOR SEMANTIC VERBAL FLUENCY: RESULTS FROM A FAMILY-BASED STUDY(2019) TAPOROSKI, Tamara; SCHANTZ, Malcolm Von; HORIMOTO, Andrea R. V. R.; DUARTE, Nubia E.; POMPEIA, Sabine; EVANS, Simon; KRIEGER, Jose E.; VALLADA, Homero; NEGRAO, Andre Brooking; PEREIRA, Alexandre C.
- Distribution and heritability of diurnal preference (chronotype) in a rural Brazilian family-based cohort, the Baependi study(2015) SCHANTZ, Malcolm von; TAPOROSKI, Tamara P.; HORIMOTO, Andrea R. V. R.; DUARTE, Nubia E.; VALLADA, Homero; KRIEGER, Jose E.; PEDRAZZOLI, Mario; NEGRAO, Andre B.; PEREIRA, Alexandre C.Diurnal preference (chronotype) is a useful instrument for studying circadian biology in humans. It harbours trait-like dimensions relating to circadian period and sleep homeostasis, but also has ontogenetic components (morningness increases with age). We used the Morningness-Eveningness questionnaire (MEQ) in the Baependi study, a family-based cohort study based in a small town in Minas Gerais, Brazil. The population is highly admixed and has a cohesive and conservative lifestyle. 825 individuals (497 female) aged 18-89 years (average +/- SD = 46.4 +/- 16.3) and belonging to 112 different families participated in this study. The average MEQ score was 63.5 +/- 11.2 with a significant (P < 0.0001) linear increase with age. Morningness was significantly (P, 0.0001) higher in the rural (70.2 +/- 9.8) than in the municipal zone (62.6 +/- 11.1), and was also significantly (P = 0.025) higher in male (64.6 +/- 10.9) than in female (62.8 +/- 11.2) participants. Thus, in spite of universal access to electricity, the Baependi population was strongly shifted towards morningness, particularly in the rural zone. Heritability of MEQ score was 0.48 when adjusted for sex and age, or 0.38 when adjusted for sex, age, and residential zone. The reported MEQ score heritability is more akin to those of previous twin studies than previous family studies.
- Metabolic syndrome alters relationships between cardiometabolic variables, cognition and white matter hyperintensity load(2019) ALKAN, E.; TAPOROSKI, T. P.; STERR, A.; SCHANTZ, M. von; VALLADA, H.; KRIEGER, J. E.; PEREIRA, A. C.; ALVIM, R.; HORIMOTO, A. R. V. R.; POMPEIA, S.; NEGRAO, A. B.; EVANS, S. L. H.Cardiometabolic risk factors influence white matter hyperintensity (WMH) development: in metabolic syndrome (MetS), higher WMH load is often reported but the relationships between specific cardiometabolic variables, WMH load and cognitive performance are uncertain. We investigated these in a Brazilian sample (aged 50-85) with (N = 61) and without (N=103) MetS. Stepwise regression models identified effects of cardiometabolic and demographic variables on WMH load (from FLAIR MRI) and verbal recall performance. WMH volume was greater in MetS, but verbal recall performance was not impaired. Age showed the strongest relationship with WMH load. Across all participants, systolic blood pressure (SBP) and fasting blood glucose were also contributors, and WMH volume was negatively associated with verbal recall performance. In non-MetS, higher HbA1c, SBP, and number of MetS components were linked to poorer recall performance while higher triglyceride levels appeared to be protective. In MetS only, these relationships were absent but education exerted a strongly protective effect on recall performance. Thus, results support MetS as a construct: the clustering of cardiometabolic variables in MetS alters their individual relationships with cognition; instead, MetS is characterised by a greater reliance on cognitive reserve mechanisms. In non-MetS, strategies to control HbA1c and SBP should be prioritised as these have the largest impact on cognition.
- Cohort profile: the Baependi Heart Study - a family-based, highly admixed cohort study in a rural Brazilian town(2016) EGAN, Kieren J.; SCHANTZ, Malcolm von; NEGRAO, Andre B.; SANTOS, Hadassa C.; HORIMOTO, Andrea R. V. R.; DUARTE, Nubia E.; GONCALVES, Guilherme C.; SOLER, Julia M. P.; ANDRADE, Mariza de; LORENZI-FILHO, Geraldo; VALLADA, Homero; TAPOROSKI, Tamara P.; PEDRAZZOLI, Mario; AZAMBUJA, Ana P.; OLIVEIRA, Camila M. de; ALVIM, Rafael O.; KRIEGER, Jose E.; PEREIRA, Alexandre C.Purpose: Cardiovascular disease (CVD) is a major challenge to global health. The same epidemiological transition scenario is replayed as countries develop, but with variations based on environment, culture and ethnic mixture. The Baependi Heart Study was set up in 2005 to develop a longitudinal family-based cohort study that reflects on some of the genetic and lifestyle-related peculiarities of the Brazilian populations, in order to evaluate genetic and environmental influences on CVD risk factor traits. Participants: Probands were recruited in Baependi, a small rural town in the state of Minas Gerais, Brazil, following by first-degree and then increasingly more distant relatives. The first follow-up wave took place in 2010, and the second in 2016. At baseline, the study evaluated 1691 individuals across 95 families. Cross-sectional data have been collected for 2239 participants. Findings to date: Environmental and lifestyle factors and measures relevant to cardiovascular health have been reported. Having expanded beyond cardiovascular health outcomes, the phenotype datasets now include genetics, biochemistry, anthropometry, mental health, sleep and circadian rhythms. Many of these have yielded heritability estimates, and a shared genetic background of anxiety and depression has recently been published. In spite of universal access to electricity, the population has been found to be strongly shifted towards morningness compared with metropolitan areas. Future plans: A new follow-up, marking 10 years of the study, is ongoing in 2016, in which data are collected as in 2010 (with the exception of the neuropsychiatric protocol). In addition to this, a novel questionnaire package collecting information about intelligence, personality and spirituality is being planned. The data set on circadian rhythms and sleep will be amended through additional questionnaires, actimetry, home sleep EEG recording and dim light melatonin onset (DLMO) analysis. Finally, the anthropometric measures will be expanded by adding three-dimensional facial photography, voice recording and anatomical brain MRI.
- Heritability of semantic verbal fluency task using time-interval analysis(2019) TAPOROSKI, T. P.; DUARTE, N. E.; POMPEIA, S.; STERR, A.; GOMEZ, L. M.; ALVIM, R. O.; HORIMOTO, R. V. R.; KRIEGER, J. E.; VALLADA, H.; PEREIRA, A. C.; SCHANTZ, M. von; NEGRAO, A. B.Individual variability in word generation is a product of genetic and environmental influences. The genetic effects on semantic verbal fluency were estimated in 1,735 participants from the Brazilian Baependi Heart Study. The numbers of exemplars produced in 60 s were broken down into time quartiles because of the involvement of different cognitive processes-predominantly automatic at the beginning, controlled/executive at the end. Heritability in the unadjusted model for the 60-s measure was 0.32. The best-fit model contained age, sex, years of schooling, and time of day as covariates, giving a heritability of 0.21. Schooling had the highest moderating effect. The highest heritability (0.17) was observed in the first quartile, decreasing to 0.09, 0.12, and 0.0003 in the following ones. Heritability for average production starting point (intercept) was 0.18, indicating genetic influences for automatic cognitive processes. Production decay (slope), indicative of controlled processes, was not significant. The genetic influence on different quartiles of the semantic verbal fluency test could potentially be exploited in clinical practice and genome-wide association studies.
- Shared Genetic Factors of Anxiety and Depression Symptoms in a Brazilian Family-Based Cohort, the Baependi Heart Study(2015) TAPOROSKI, Tamara P.; NEGRAO, Andre B.; HORIMOTO, Andrea R. V. R.; DUARTE, Nubia E.; ALVIM, Rafael O.; OLIVEIRA, Camila M. de; KRIEGER, Jose E.; SCHANTZ, Malcolm von; VALLADA, Homero; PEREIRA, Alexandre C.To investigate the phenotypic and genetic overlap between anxiety and depression symptoms in an admixed population from extended family pedigrees. Participants (n = 1,375) were recruited from a cohort of 93 families (mean age +/- SD 42 +/- 16.3, 57% female) in the rural town of Baependi, Brazil. The Hospital Anxiety and Depression Scale (HADS) was used to assess depression and anxiety symptoms. Heritability estimates were obtained by an adjusted variance component model. Bivariate analyses were performed to obtain the partition of the covariance of anxiety and depression into genetic and environmental components, and to calculate the genetic contribution modulating both sets of symptoms. Anxiety and depression scores were 7.49 +/- 4.01 and 5.70 +/- 3.82, respectively. Mean scores were affected by age and were significantly higher in women. Heritability for depression and anxiety, corrected for age and sex, were 0.30 and 0.32, respectively. Significant genetic correlations (p(g) = 0.81) were found between anxiety and depression scores; thus, nearly 66% of the total genetic variance in one set of symptoms was shared with the other set. Our results provided strong evidence for a genetic overlap between anxiety and depression symptoms, which has relevance for our understanding of the biological basis of these constructs and could be exploited in genome-wide association studies.
- PER3 POLYMORPHISMS, MORNINGNESS-EVENINGNESS AND DEPRESSION: PRELIMINARY EVIDENCE IN A BRAZILIAN FAMILY-BASED COHORT, THE BAEPENDI HEART STUDY(2019) RUIZ, Francieli; TAPOROSKI, Tamara P.; MARTINEZ, Daniela; BEALE, Andrew; BEIJAMINI, Felipe; KRIEGER, Jose E.; KNUTSON, Kristen L.; PEREIRA, Alexandre; PEDRAZZOLI, Mario; VALLADA, Homero; SCHANTZ, Malcolm Von
- Early chronotype with advanced activity rhythms and dim light melatonin onset in a rural population(2020) RUIZ, Francieli S.; BEIJAMINI, Felipe; BEALE, Andrew D.; GONCALVES, Bruno da Silva B.; VARTANIAN, Daniel; TAPOROSKI, Tamara P.; MIDDLETON, Benita; KRIEGER, Jose E.; VALLADA, Homero; ARENDT, Josephine; PEREIRA, Alexandre C.; KNUTSON, Kristen L.; PEDRAZZOLI, Mario; SCHANTZ, Malcolm vonStudying communities at different stages of urbanisation and industrialisation can teach us how timing and intensity of light affect the circadian clock under real-life conditions. We have previously described a strong tendency towards morningness in the Baependi Heart Study, located in a small rural town in Brazil. Here, we tested the hypothesis that this morningness tendency is associated with early circadian phase based on objective measurements (as determined by dim light melatonin onset, DLMO, and activity) and light exposure. We also analysed how well the previously collected chronotype questionnaire data were able to predict these DLMO values. The average DLMO observed in 73 participants (40 female) was 20:03 +/- 01:21, SD, with an earlier average onset in men (19:38 +/- 01:16) than in women (20:24 +/- 01:21;P <= .01). However, men presented larger phase angle between DLMO and sleep onset time as measured by actigraphy (4.11 hours vs 3.16 hours;P <= .01). Correlational analysis indicated associations between light exposure, activity rhythms and DLMO, such that early DLMO was observed in participants with higher exposure to light, higher activity and earlier light exposure. The strongest significant predictor of DLMO was morningness-eveningness questionnaire (MEQ) (beta=-0.35,P <= .05), followed by age (beta = -0.47,P <= .01). Sex, light exposure and variables derived from the Munich chronotype questionnaire were not significant predictors. Our observations demonstrate that both early sleep patterns and earlier circadian phase have been retained in this small rural town in spite of availability of electrification, in contrast to metropolitan postindustrial areas.
- Distribution and heritability of diurnal preference (chronotype) in a rural Brazilian family-based cohort, the Baependi study(2015) SCHANTZ, M. Von; TAPOROSKI, T.; HORIMOTO, A.; ESTEBAN, N.; VALLADA, H.; KRIEGER, J.; PEDRAZZOLI, M.; NEGRAO, A.; PEREIRA, A.
- Amerindian (but not African or European) ancestry is significantly associated with diurnal preference within an admixed Brazilian population(2017) EGAN, Kieren J.; SANTOS, Hadassa Campos; BEIJAMINI, Felipe; DUARTE, Nubia E.; HORIMOTO, Andrea R. V. R.; TAPOROSKI, Tamara P.; VALLADA, Homero; NEGRAO, Andre B.; KRIEGER, Jose E.; PEDRAZZOLI, Mario; KNUTSON, Kristen L.; PEREIRA, Alexandre C.; SCHANTZ, Malcolm vonSignificant questions remain unanswered regarding the genetic versus environmental contributions to racial/ethnic differences in sleep and circadian rhythms. We addressed this question by investigating the association between diurnal preference, using the morningness-eveningness questionnaire (MEQ), and genetic ancestry within the Baependi Heart Study cohort, a highly admixed Brazilian population based in a rural town. Analysis was performed using measures of ancestry, using the Admixture program, and MEQ from 1,453 individuals. We found an association between the degree of Amerindian (but not European of African) ancestry and morningness, equating to 0.16 units for each additional percent of Amerindian ancestry, after adjustment for age, sex, education, and residential zone. To our knowledge, this is the first published report identifying an association between genetic ancestry and MEQ, and above all, the first one based on ancestral contributions within individuals living in the same community. This previously unknown ancestral dimension of diurnal preference suggests a stratification between racial/ethnic groups in an as yet unknown number of genetic polymorphisms.