TAMARA PESSANHA TAPOROSKI
Projetos de Pesquisa
Unidades Organizacionais
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
4 resultados
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- Metabolic syndrome alters relationships between cardiometabolic variables, cognition and white matter hyperintensity load(2019) ALKAN, E.; TAPOROSKI, T. P.; STERR, A.; SCHANTZ, M. von; VALLADA, H.; KRIEGER, J. E.; PEREIRA, A. C.; ALVIM, R.; HORIMOTO, A. R. V. R.; POMPEIA, S.; NEGRAO, A. B.; EVANS, S. L. H.Cardiometabolic risk factors influence white matter hyperintensity (WMH) development: in metabolic syndrome (MetS), higher WMH load is often reported but the relationships between specific cardiometabolic variables, WMH load and cognitive performance are uncertain. We investigated these in a Brazilian sample (aged 50-85) with (N = 61) and without (N=103) MetS. Stepwise regression models identified effects of cardiometabolic and demographic variables on WMH load (from FLAIR MRI) and verbal recall performance. WMH volume was greater in MetS, but verbal recall performance was not impaired. Age showed the strongest relationship with WMH load. Across all participants, systolic blood pressure (SBP) and fasting blood glucose were also contributors, and WMH volume was negatively associated with verbal recall performance. In non-MetS, higher HbA1c, SBP, and number of MetS components were linked to poorer recall performance while higher triglyceride levels appeared to be protective. In MetS only, these relationships were absent but education exerted a strongly protective effect on recall performance. Thus, results support MetS as a construct: the clustering of cardiometabolic variables in MetS alters their individual relationships with cognition; instead, MetS is characterised by a greater reliance on cognitive reserve mechanisms. In non-MetS, strategies to control HbA1c and SBP should be prioritised as these have the largest impact on cognition.
- Heritability of semantic verbal fluency task using time-interval analysis(2019) TAPOROSKI, T. P.; DUARTE, N. E.; POMPEIA, S.; STERR, A.; GOMEZ, L. M.; ALVIM, R. O.; HORIMOTO, R. V. R.; KRIEGER, J. E.; VALLADA, H.; PEREIRA, A. C.; SCHANTZ, M. von; NEGRAO, A. B.Individual variability in word generation is a product of genetic and environmental influences. The genetic effects on semantic verbal fluency were estimated in 1,735 participants from the Brazilian Baependi Heart Study. The numbers of exemplars produced in 60 s were broken down into time quartiles because of the involvement of different cognitive processes-predominantly automatic at the beginning, controlled/executive at the end. Heritability in the unadjusted model for the 60-s measure was 0.32. The best-fit model contained age, sex, years of schooling, and time of day as covariates, giving a heritability of 0.21. Schooling had the highest moderating effect. The highest heritability (0.17) was observed in the first quartile, decreasing to 0.09, 0.12, and 0.0003 in the following ones. Heritability for average production starting point (intercept) was 0.18, indicating genetic influences for automatic cognitive processes. Production decay (slope), indicative of controlled processes, was not significant. The genetic influence on different quartiles of the semantic verbal fluency test could potentially be exploited in clinical practice and genome-wide association studies.
- Shared Genetic Factors of Anxiety and Depression Symptoms in a Brazilian Family-Based Cohort, the Baependi Heart Study(2015) TAPOROSKI, Tamara P.; NEGRAO, Andre B.; HORIMOTO, Andrea R. V. R.; DUARTE, Nubia E.; ALVIM, Rafael O.; OLIVEIRA, Camila M. de; KRIEGER, Jose E.; SCHANTZ, Malcolm von; VALLADA, Homero; PEREIRA, Alexandre C.To investigate the phenotypic and genetic overlap between anxiety and depression symptoms in an admixed population from extended family pedigrees. Participants (n = 1,375) were recruited from a cohort of 93 families (mean age +/- SD 42 +/- 16.3, 57% female) in the rural town of Baependi, Brazil. The Hospital Anxiety and Depression Scale (HADS) was used to assess depression and anxiety symptoms. Heritability estimates were obtained by an adjusted variance component model. Bivariate analyses were performed to obtain the partition of the covariance of anxiety and depression into genetic and environmental components, and to calculate the genetic contribution modulating both sets of symptoms. Anxiety and depression scores were 7.49 +/- 4.01 and 5.70 +/- 3.82, respectively. Mean scores were affected by age and were significantly higher in women. Heritability for depression and anxiety, corrected for age and sex, were 0.30 and 0.32, respectively. Significant genetic correlations (p(g) = 0.81) were found between anxiety and depression scores; thus, nearly 66% of the total genetic variance in one set of symptoms was shared with the other set. Our results provided strong evidence for a genetic overlap between anxiety and depression symptoms, which has relevance for our understanding of the biological basis of these constructs and could be exploited in genome-wide association studies.
conferenceObject HERITABILITY AND SHARED GENETIC FACTORS FOR SYMPTOMS OF ANXIETY AND DEPRESSION IN A BRAZILIAN FAMILY-BASED COHORT, THE BAEPENDI STUDY(2017) TAPOROSKI, Tamara; NEGRAO, Andre Brooking; HORIMOTO, Andrea R. V. R.; DUARTE, Nubia E.; ALVIM, Rafael O.; OLIVEIRA, Camila M. de; KRIEGER, Jose E.; SCHANTZ, Malcolm Von; VALLADA, Homero; PEREIRA, Alexandre C.