ANDREA SCHMITT
Projetos de Pesquisa
Unidades Organizacionais
LIM/27 - Laboratório de Neurociências, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Improvement in daily functioning after aerobic exercise training in schizophrenia is sustained after exercise cessation(2021) FALKAI, Peter; MAURUS, Isabel; SCHMITT, Andrea; MALCHOW, Berend; SCHNEIDER-AXMANN, Thomas; ROELL, Lukas; PAPIOL, Sergi; WOBROCK, Thomas; HASAN, Alkomiet; KEESER, Daniel
- Differential gene regulation in the anterior cingulate cortex and superior temporal cortex in schizophrenia: A molecular network approach(2021) GEBICKE-HAERTER, Peter J.; LEONARDI-ESSMANN, Fernando; HAERTER, Jan O.; ROSSNER, Moritz J.; FALKAI, Peter; SCHMITT, Andrea; RAABE, Florian J.The closely connected anterior cingulate cortex (ACC) and superior temporal cortex (STC) are important for higher cognitive functions. Both brain regions are disturbed in schizophrenia, i.e., functional and structural alterations have been reported. This postmortem investigation in brains from patients with schizophrenia and controls compared gene expression in the left ACC and left STC. Most differentially expressed genes were unique to each brain region, but some clusters of genes were equally dysregulated in both, giving rise to a more general disease-specific pattern of gene regulation. The data was used to construct a molecular network of the genes identically expressed in both regions as primary nodes and the metabolically connected genes as secondary nodes. The network analysis identified downregulated clusters of immune-associated gene products and upregulated clusters belonging to the ubiquitin-proteasome system. These findings could help to identify new potential therapeutic targets for future approaches.
- Aerobic endurance training to improve cognition and enhance recovery in schizophrenia: design and methodology of a multicenter randomized controlled trial(2021) MAURUS, Isabel; HASAN, Alkomiet; SCHMITT, Andrea; ROEH, Astrid; KEESER, Daniel; MALCHOW, Berend; SCHNEIDER-AXMANN, Thomas; HELLMICH, Martin; SCHMIED, Sabine; LEMBECK, Moritz; KELLER-VARADY, Katriona; PAPAZOVA, Irina; HIRJAK, Dusan; TOPOR, Cristina E.; WALTER, Henrik; MOHNKE, Sebastian; VOGEL, Bob O.; WOELWER, Wolfgang; SCHNEIDER, Frank; HENKEL, Karsten; MEYER-LINDENBERG, Andreas; FALKAI, PeterEven today, patients with schizophrenia often have an unfavorable outcome. Negative symptoms and cognitive deficits are common features in many patients and prevent recovery. In recent years, aerobic endurance training has emerged as a therapeutic approach with positive effects on several domains of patients' health. However, appropriately sized, multicenter randomized controlled trials that would allow better generalization of results are lacking. The exercise study presented here is a multicenter, rater-blind, two-armed, parallel-group randomized clinical trial in patients with clinically stable schizophrenia being conducted at five German tertiary hospitals. The intervention group performs aerobic endurance training on bicycle ergometers three times per week for 40-50 min/session (depending on the intervention week) for a total of 26 weeks, and the control group performs balance and tone training for the same amount of time. Participants are subsequently followed up for 26 weeks. The primary endpoint isall-cause discontinuation; secondary endpoints include psychopathology, cognition, daily functioning, cardiovascular risk factors, and explorative biological measures regarding the underlying mechanisms of exercise. A total of 180 patients will be randomized. With currently 162 randomized participants, our study is the largest trial to date to investigate endurance training in patients with schizophrenia. We hypothesize that aerobic endurance training has beneficial effects on patients' mental and physical health, leading to lower treatment discontinuation rates and improving disease outcomes. The study results will provide a basis for recommending exercise interventions as an add-on therapy in patients with schizophrenia.The study is registered in the International Clinical Trials Database (ClinicalTrials.gov identifier [NCT number]: NCT03466112) and in the German Clinical Trials Register (DRKS-ID: DRKS00009804).
- Association Between Physical Activity and Schizophrenia Results of a 2-Sample Mendelian Randomization Analysis(2021) PAPIOL, Sergi; SCHMITT, Andrea; MAURUS, Isabel; ROSSNER, Moritz J.; SCHULZE, Thomas G.; FALKAI, Peter
- Aerobic endurance training to improve cognition and enhance recovery in schizophrenia: design and methodology of a multicenter randomized controlled trial (vol 271, pg 315, 2021)(2021) MAURUS, Isabel; HASAN, Alkomiet; SCHMITT, Andrea; ROEH, Astrid; KEESER, Daniel; MALCHOW, Berend; SCHNEIDER-AXMANN, Thomas; HELLMICH, Martin; SCHMIED, Sabine; LEMBECK, Moritz; KELLER-VARADY, Katriona; PAPAZOVA, Irina; HIRJAK, Dusan; TOPOR, Cristina E.; WALTER, Henrik; MOHNKE, Sebastian; VOGEL, Bob O.; WOELWER, Wolfgang; SCHNEIDER, Frank; HENKEL, Karsten; MEYER-LINDENBERG, Andreas; FALKAI, Peter
- Exercise as a model to identify microRNAs linked to human cognition: a role for microRNA-409 and microRNA-501(2021) GOLDBERG, Maria; ISLAM, Md Rezaul; KERIMOGLU, Cemil; LANCELIN, Camille; GISA, Verena; BURKHARDT, Susanne; KRUEGER, Dennis M.; MARQUARDT, Till; MALCHOW, Berend; SCHMITT, Andrea; FALKAI, Peter; SANANBENESI, Farahnaz; FISCHER, AndreMicroRNAs have been linked to synaptic plasticity and memory function and are emerging as potential biomarkers and therapeutic targets for cognitive diseases. Most of these data stem from the analysis of model systems or postmortem tissue from patients which mainly represents an advanced stage of pathology. Due to the in-accessibility of human brain tissue upon experimental manipulation, it is still challenging to identify microRNAs relevant to human cognition, which is however a key step for future translational studies. Here, we employ exercise as an experimental model for memory enhancement in healthy humans with the aim to identify microRNAs linked to memory function. By analyzing the circulating smallRNAome we find a cluster of 18 microRNAs that are highly correlated to cognition. MicroRNA-409-5p and microRNA-501-3p were the most significantly regulated candidates. Functional analysis revealed that the two microRNAs are important for neuronal integrity, synaptic plasticity, and morphology. In conclusion, we provide a novel approach to identify microRNAs linked to human memory function.