ESTELA AZEKA

(Fonte: Lattes)
Índice h a partir de 2011
8
Lattes
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico

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Agora exibindo 1 - 4 de 4
  • article 6 Citação(ões) na Scopus
    The past, present and future of clinical research
    (2011) AZEKA, Estela; FREGNI, Felipe; AULER JUNIOR, Jose Otavio Costa
  • article 7 Citação(ões) na Scopus
    Clinical research in pediatric organ transplantation
    (2014) AZEKA, Estela; SAAVEDRA, Laura Castillo; FREGNI, Felipe
    Solid organ transplantation has greatly improved survival in children with end-stage disease, becoming one of the main treatment options in this population. Nonetheless, there are significant challenges associated with validating and optimizing the effects of these interventions in clinical trials. Therefore, we reviewed the main issues related to conducting clinical transplantation research in children. We divided these challenges into three different categories: (i) challenges related to surgical techniques and anesthetic procedures, (ii) challenges related to post-transplant care and (iii) challenges specific to a particular population group and disease type. Some of the observed burdens for clinical research in this field are related to the limitations of conducting studies with a placebo or sham procedure, determining the standard of care for a control group, low prevalence of cases, ethical concerns related to use of a placebo control group and lack of generalizability from animal studies and clinical trials conducted in adult populations. To overcome some of these barriers, it is necessary to utilize alternative clinical trial designs, such as observational studies or non-inferiority trials, and to develop multicenter collaborations to increase the recruitment rate. In conclusion, the lack of robust data related to pediatric transplantation remains problematic, and further clinical trials are needed to develop more efficacious and safer treatments.
  • article 5 Citação(ões) na Scopus
    Clinical recommendations for postoperative care after heart transplantation in children: 21 years of a single-center experience
    (2014) AZEKA, Estela; JATENE, Marcelo Biscegli; TANAKA, Ana Cristina; GALAS, Filomena Regina; HAJJAR, Ludhmilla Abrahao; MIURA, Nana; AULER JUNIOR, Jose Otavio Costa
    Heart transplantation is an option for children with complex congenital heart disease and cardiomyopathies. A patient's quality of life and long-term survival depend on successful management of the surgical complications and adverse side effects of immunosuppression. The purpose of this review was to summarize the practical management of postoperative care in this patient population and to make recommendations for the future.
  • article 0 Citação(ões) na Scopus
    Common challenge topics in pediatric transplantation
    (2014) AZEKA, Estela; JATENE, Marcelo Biscegli; MIURA, Nana; FINE, Richard
    This special issue is dedicated to the common challenge topics in pediatric transplantation. It contains 11 chapters, ranging from clinical research in pediatric transplantation to translational research (from bench to bedside). It includes comprehensive reviews from renowned scientists, clinicians and surgeons from five countries from the International Pediatric Transplantation Association (IPTA), Harvard University, the University of Miami and the University of Sao Paulo Medical School. The clinical management of specific issues, such as sensitized patients and ABO blood type- incompatible transplantation, is addressed. In addition, the challenges facing this patient population and the future perspectives for clinical research are discussed.