FERNANDA MARCIANO CONSOLIM COLOMBO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
6 resultados
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- Effects of a contraceptive containing drospirenone and ethinyl estradiol on blood pressure and autonomic tone: a prospective controlled clinical trial(2014) NISENBAUM, Marcelo Gil; MELO, Nilson Roberto de; GIRIBELA, Cassiana Rosa Galvao; MORAIS, Tercio Lemos de; GUERRA, Grazia Maria; ANGELIS, Katia de; MOSTARDA, Cristiano; BARACAT, Edmund Chada; CONSOLIM-COLOMBO, Fernanda MarcianoBackground: The use of combined oral contraceptives has been associated with an increased risk of adverse cardiovascular events. Whether these drugs alter cardiac autonomic nervous system control is not completely determined. Objective: To evaluate the effect of a contraceptive containing 20 mcg of ethinyl estradiol and 3 mg of drospirenone on the heart rate variability, baroreflex sensitivity and blood pressure of healthy women. Study design: Prospective controlled trial with 69 healthy women allocated in two groups: 36 volunteers under oral combined contraceptive use and 33 volunteers using of non-hormonal contraceptive methods. Subjects were tested before the introduction of the contraceptive method and 6 months after its use. For data acquisition, we used continuous non-invasive beat-to-beat blood pressure curve recordings. Multiple ANOVA was used to determine differences between groups and moments and p < 0.05 was considered statistically significant. Results: At baseline, there were no differences in demographic and autonomic parameters between groups. Comparing cardiac sympatho-vagal modulation, baroreceptor sensitivity and blood pressure measurements between baseline and after 6 months, no significant difference was detected in each group or between groups. Conclusion: A contraceptive containing 20 mcg of ethinyl estradiol and 3 mg of drospirenone causes no significant changes in clinical, hemodynamic and autonomic parameters of normal women.
- Hemodynamic Effect of Laser Therapy in Spontaneously Hypertensive Rats(2014) TOMIMURA, Suely; SILVA, Bianca Passos Assumpcao; SANCHES, Iris Callado; CANAL, Marina; CONSOLIM-COLOMBO, Fernanda; CONTI, Felipe Fernandes; ANGELIS, Katia De; CHAVANTES, Maria CristinaSystemic arterial hypertension (SAH) is considered to be the greatest risk factor for the development of neuro-cardiovascular pathologies, thus constituting a severe Public Health issue in the world. The Low-Level Laser Therapy (LLLT), or laser therapy, activates components of the cellular structure, therefore converting luminous energy into photochemical energy and leading to biophysical and biochemical reactions in the mitochondrial respiratory chain. The LLLT promotes cellular and tissue photobiomodulation by means of changes in metabolism, leading to molecular, cellular and systemic changes. The objective of this study was to analyze the action of low-level laser in the hemodynamic modulation of spontaneously hypertensive rats, in the long term. Animals (n = 16) were randomly divided into the Laser Group (n = 8), which received three weekly LLLT irradiations for seven weeks, and into the Sham Group (n = 8), which received three weekly simulations of laser for seven weeks, accounting for 21 applications in each group. After seven weeks, animals were cannulated by the implantation of a catheter in the left carotid artery. On the following day, the systemic arterial pressure was recorded. The Laser Group showed reduced levels of mean blood pressure, with statistically significant reduction (169 +/- 4 mmHg* vs. 182 +/- 4 mmHg from the Sham Group) and reduced levels of diastolic pressure (143 +/- 4 mmHg* vs. 157 +/- 3 mmHg from the Sham Group), revealing a 13 and 14 mmHg decrease, respectively. Besides, there was a concomitant important decline in heart rate (312 +/- 14 bpm vs. 361 +/- 13 bpm from the Sham Group). Therefore, laser therapy was able to produce hemodynamic changes, thus reducing pressure levels in spontaneously hypertensive rats.
- Effects of a contraceptive containing drospirenone and ethinylestradiol on blood pressure, metabolic profile and neurohumoral axis in hypertensive women at reproductive age(2014) MORAIS, Tercio Lemos de; GIRIBELA, Cassiana; NISENBAUM, Marcelo Gil; GUERRA, Grazia; MELLO, Nilson; BARACAT, Edmundo; CONSOLIM-COLOMBO, Fernanda M.The use of combined oral contraceptives is widespread among hypertensive women despite being associated with increased cardiovascular risk. Contraceptives containing drospirenone, which has antimineralocorticoid properties, may have a positive or neutral effect on neurohumoral activation and metabolic homeostasis of hypertensive women at reproductive age. Objectives: To evaluate the effect of combined oral contraceptive containing drospirenone + ethinylestradiol on the systemic blood pressure, metabolic variables and neurohumoral axis in hypertensive women in reproductive age. Design: Prospective controlled trial with 56 hypertensive women allocated in two groups: 30 volunteers under oral combined contraceptive use and 26 volunteers using non-hormonal contraceptive methods. Subjects were tested before the introduction of the contraceptive method and 6 months after its use. For data acquisition, we used continuous non-invasive beat-to-beat blood pressure curve recordings and, for the biochemical and hormonal analyses two blood samples were obtained. Student's t test was used to determine differences between groups and moments and p < 0.05 was considered statistically significant. Results: Comparing antropometric and blood pressure measurements, cardiac sympatho-vagal modulation, baroreceptor sensitivity, metabolic and neurohumoral axis variables between baseline and after 6 months, no significant difference was detected in each group or between groups. Except serum triglyceride levels which increased in the group of women using EE + DRSP after 6 months of use. Conclusion: A contraceptive containing 20 mcg of ethinyl estradiol and 3 mg of drospirenone causes no significant changes in clinical and autonomic parameters, metabolic variables and neurohumoral axis of hypertensive women.
article 20 Citação(ões) na Scopus Cardiovascular autonomic dysfunction in primary ovarian insufficiency: clinical and experimental evidence(2014) GOLDMEIER, Silvia; ANGELIS, Katia De; CASALI, Karina Rabello; VILODRE, Cesar; CONSOLIM-COLOMBO, Fernanda; KLEIN, Adriane Bello; PLENTZ, Rodrigo; SPRITZER, PoliMara; IRIGOYEN, Maria-ClaudiaObjective: Women with primary ovarian insufficiency (POI) present an increased risk for cardiovascular disease. In this study we tested the hypothesis that POI in women under hormone therapy (HT) are associated with vascular vasodilatation attenuation and cardiovascular autonomic dysfunction and these impairments are related to changes in systemic antioxidant enzymes. Furthermore, the possibility that ovarian hormone deprivation can induce such changes and that HT cannot reverse all of those impairments was examined in an experimental model of POI. Methods: Fifteen control and 17 patients with primary ovarian insufficiency receiving HT were included in the study. To test the systemic and cardiac consequences of ovarian hormone deprivation, ovariectomy was induced in young female rats that were submitted or not to HT. Spectral analysis of RR interval and blood pressure signals were performed and oxidative stress parameters were determined. Results: POI women under HT have increased mean arterial pressure (94 +/- 10 vs. 86 +/- 5 mmHg) despite normal endothelial and autonomic modulation of vasculature. Additionally, they presented impaired baroreflex sensitivity (3.9 +/- 1.38 vs. 7.15 +/- 3.62 ms/mmHg) and reduced heart rate variability (2310 +/- 1173 vs. 3754 +/- 1921 ms(2)). Similar results obtained in ovariectomized female rats were accompanied by an increased lipoperoxidation (7433 +/- 1010 vs. 6180 +/- 289 cps/mg protein) and decreased antioxidant enzymes in cardiac tissue. As it was observed in women, the HT in animals did not restore hemodynamic and autonomic dysfunctions. Conclusion: These data provide clinical and experimental evidence that long term HT may not restore all cardiovascular risk factors associated with ovarian hormone deprivation.- Prevalence of cardiovascular risk factors among truck drivers in the South of Brazil(2014) SANGALETI, Carine Teles; TRINCAUS, Maria Regiane; BARATIERI, Tatiane; ZAROWY, Kaline; LADIKA, Maria Bernardete; MENON, Mario Umberto; MIYAHARA, Ricardo Yoshimitsu; RAIMONDO, Maria Isabel; SILVEIRA, Joao Vicente; BORTOLOTTO, Luis Aparecido; LOPES, Heno Ferreira; CONSOLIM-COLOMBO, Fernanda M.Background: Truck drivers work under conditions that predispose them to a high prevalence of risk factors for the development of cardiovascular disease (CVD); however, these factors have not been fully evaluated and are not usually considered to be within the scope of health or labor services. Methods: An observational cross-sectional study was conducted on 250 long-distance truck drivers; the drivers were all male and were aged 18-60 years. The clinical evaluation consisted of an assessment of social habits and demographic data and an evaluation of risk factors for CVD at 3 time points separated by a one-week interval. To assess the associations with risk factors were used univariate and multivariate analysis. The suitability of the final model fit was assessed via the Hosmer-Lemeshow test. The significance level was set at 5%. Results: Among all of the subjects, the prevalence of physical inactivity was 72.8%; consumption of alcoholic beverages, 66.8%; routine use of some type of stimulant during work activities, 19.2%; and smoking, 29%. Only 20.8% had a healthy weight, and 58.2% had an abdominal circumference greater than 102 cm. A diagnosis of arterial hypertension was confirmed in 45.2%, and abnormal glucose levels were detected in 16.4%. Although some of the truck drivers were aware of these conditions, most were not taking specific medications. The logistic regression analysis shows that the odds of hypertension and abnormal glucose levels were increased in truck drivers with abdominal obesity. Age and the family history of premature CVD also increased the chances of hypertension and the abnormal blood glucose levels were related to II or III grade obesity. Conclusion: Long-distance truck drivers showed a high prevalence of a cluster of cardiovascular risk factors; these risk factors make the drivers highly susceptible to the development of CVD. The associated risk factors, low compliance with drug treatment, and unique features of this profession suggest that traditional precautions are not sufficient to change this scenario.
- Role of Exercise Training on Autonomic Changes and Inflammatory Profile Induced by Myocardial Infarction(2014) RODRIGUES, Bruno; LIRA, Fabio S.; CONSOLIM-COLOMBO, Fernanda M.; ROCHA, Juraci A.; CAPERUTO, Erico C.; ANGELIS, Katia De; IRIGOYEN, Maria-ClaudiaThe cardiovascular autonomic imbalance in patients after myocardial infarction (MI) provides a significant increase in mortality rate, and seems to precede metabolic, hormonal, and immunological changes. Moreover, the reduction in the parasympathetic function has been associated with inflammatory response in different pathological conditions. Over the years, most of the studies have indicated the exercise training (ET) as an important nonpharmacological tool in the management of autonomic dysfunction and reduction in inflammatory profile after a myocardial infarction. In this work, we reviewed the effects of ET on autonomic imbalance after MI, and its consequences, particularly, in the post-MI inflammatory profile. Clinical and experimental evidence regarding relationship between alterations in autonomic regulation and local or systemic inflammation response after MI were also discussed.