ALEXIS GERMAN MURILLO CARRASCO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Correlation of a microRNA expression profile and the prognosis of penile cancer: A prospective study using microarray data analysis(2018) FURUYA, Tatiane K.; MURTA, Claudio B.; PONTES JR., Jose; UNO, Miyuki; CARRASCO, Alexis; SICHERO, Laura C.; VILLA, Luisa L.; COELHO, Rafael F.; GUGLIELMETTI, Giuliano B.; CORDEIRO, Mauricio D.; LEITE, Katia R.; SROUGI, Miguel; CHAMMAS, Roger; NAHAS, William C.
conferenceObject CORRELATION BETWEEN MICRORNAS AND MRNA EXPRESSION PROFILES WITH THE PROGNOSIS OF CLINICALLY LOCALIZED PENILE CANCER(2019) MURTA, Claudio; PONTES JR., Jose; FURUYA, Tatiane; UNO, Miyuki; CARRASCO, Alexis; COELHO, Rafael; GUGLIELMETTI, Giuliano; CORDEIRO, Mauricio; FARAJ, Sheila; LEITE, Katia; SICHERO, Laura; VILLA, Luisa; SROUGI, Miguel; CHAMMAS, Roger; NAHAS, William- Simultaneous silencing of lysophosphatidylcholine acyltransferases 1-4 by nucleic acid nanoparticles (NANPs) improves radiation response of melanoma cells(2021) SAITO, Renata F.; RANGEL, Maria Cristina; HALMAN, Justin R.; CHANDLER, Morgan; ANDRADE, Luciana Nogueira de Sousa; ODETE-BUSTOS, Silvina; FURUYA, Tatiane Katsue; CARRASCO, Alexis German Murillo; CHAVES-FILHO, Adriano B.; YOSHINAGA, Marcos Y.; MIYAMOTO, Sayuri; AFONIN, Kirill A.; CHAMMAS, RogerRadiation induces the generation of platelet-activating factor receptor (PAF-R) ligands, including PAF and oxidized phospholipids. Alternatively, PAF is also synthesized by the biosynthetic enzymes lysophosphatidylcholine acyltransferases (LPCATs) which are expressed by tumor cells including melanoma. The activation of PAF-R by PAF and oxidized lipids triggers a survival response protecting tumor cells from radiation-induced cell death, suggesting the involvement of the PAF/PAF-R axis in radioresistance. Here, we investigated the role of LPCATs in the melanoma cell radiotherapy response. LPCAT is a family of four enzymes, LPCAT1-4, and modular nucleic acid nanoparticles (NANPs) allowed for the simultaneous silencing of all four LPCATs. We found that the in vitro simultaneous silencing of all four LPCAT transcripts by NANPs enhanced the therapeutic effects of radiation in melanoma cells by increasing cell death, reducing long-term cell survival, and activating apoptosis. Thus, we propose that NANPs are an effective strategy for improving radiotherapy efficacy in melanomas.
bookPart Biomarcadores(2022) CARRASCO, Alexis German Murillo; UNO, MiyukiconferenceObject Correlation of the expression of microRNA and their predicted targets with prognosis and mortality of penile squamous cell carcinoma(2022) MURTA, C. B.; FURUYA, T. K.; UNO, M.; CARRASCO, A. G. M.; SICHERO, L.; VILLA, L. L.; FARAJ, S. F.; COELHO, R. F.; GUGLIELMETTI, G. B.; CORDEIRO, M. D.; LEITE, K. R. M.; NAHAS, W. C.; CHAMMAS, R.; PONTES, Jr J.- Correlation of microRNA expression profile and prognosis of penile cancer: A prospective study using microarray data analysis(2018) MURTA, Claudio Bovolenta; PONTES JR., Jose; FURUYA, Tatiane Katsue; UNO, Miyuki; CARRASCO, Alexis; SICHERO, Laura; VILLA, Luisa Lina; CORDEIRO, Mauricio; GUGLIELMETTI, Giuliano; COELHO, Rafael; LEITE, Katia Ramos Moreira; SROUGI, Miguel; CHAMMAS, Roger; NAHAS, William Carlos