DELMAR MUNIZ LOURENCO JUNIOR

(Fonte: Lattes)
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Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/25 - Laboratório de Endocrinologia Celular e Molecular, Hospital das Clínicas, Faculdade de Medicina

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  • bookPart
    Neoplasias Endócrinas Múltiplas
    (2016) LOURENçO JUNIOR, Delmar Muniz; HOFF, Ana Amélia Fialho de Oliveira; TOLEDO, Rodrigo de Almeida; TOLEDO, Sergio Pereira de Almeida
  • article 7 Citação(ões) na Scopus
    Efficacy and Long-Term Safety of Everolimus in Pancreatic Neuroendocrine Tumor Associated with Multiple Endocrine Neoplasia Type I: Case Report
    (2016) MAIA, Manuel C. D. F.; LOURENCO JR., Delmar Muniz; RIECHELMANN, Rachel
    Background: Approximately 10% of pancreatic neuroendocrine tumors (NET) are associated with familial syndromes, with the most common type being multiple endocrine neoplasia type 1 (MEN-1). However, the available evidence on how to treat NET comes from studies in sporadic NET. Case Report: Here we report the case of a 51-year-old male patient with a metastatic MEN-1-associated pancreatic NET and hypercalcemia related to primary hyperparathyroidism and tumor-secreted parathyroid-related protein. The patient was treated with everolimus, and showed complete resolution of hypercalcemia and tumor control for 3 years when he presented with pulmonary cryptococcosis and disease progression. Conclusion: This case report describes the activity of everolimus in a patient with MEN-1-associated pancreatic NET, its efficacy in treating malignant hypercalcemia associated with NET and the risk of opportunistic infections with prolonged use of this agent. (C) 2016 S. Karger GmbH, Freiburg