ANDRE LUIZ NUNES GOBATTO
Projetos de Pesquisa
Unidades Organizacionais
LIM/08 - Laboratório de Anestesiologia, Hospital das Clínicas, Faculdade de Medicina
2 resultados
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- Inflammatory, nutritional and clinical parameters of individuals with chronic kidney disease undergoing conservative treatment(2015) ALMEIDA, Alessandra Fortes; GUSMAO-SENA, Maria Helena Lima; OLIVEIRA, Layne Carla Gonzaga; GOMES, Tarcisio Santana; NASCIMENTO, Thais Vitorino Neves do; GOBATTO, Andre Luiz Nunes; SAMPAIO, Lilian Ramos; BARRETO-MEDEIROS, Jairza MariaIntroduction: due to the relevance of inflammation in individuals with chronic kidney disease (CKD), inflammation should be taken into account in the interpretation of the clinical-nutritional status. Objective: assess the association between inflammation, nutritional and clinical parameters in patients with CKD. Materials and methods: 92 patients with CKD. C-reactive protein (CRP) was used as an inflammation marker. Assessed nutritional parameters were anthropometry and biochemical exams. Evaluated clinical parameters were comorbidities, CKD characteristics, lipid profile, lipid-lowering agents, urea, creatinine and total leukocytes. Comparisons between two groups (with or without inflammation) were performed using Student's t-test or chi-square test. Results: 15 (16.3%) patients had CRP above >= 10mg/L and were considered with inflammation. In the group with inflammation, 05 (33%) had hypoalbuminemia as compared with 05 (6.5%) in the group without inflammation (p = 0.002). Lipid values were lower in the group with inflammation, with mean total cholesterol 171 (+/- 41.2) mg/dL and mean LDL-C 95 (+/- 31.2) mg/dL as compared with the group without inflammation, which had and a mean total cholesterol 198 (46) mg/dL and mean LDL-C 124 (+/- 40.1) mg/dL, p = 0,038 and p = 0.011, respectively. No other statistically significant differences between groups were found. Conclusion: inflammation was associated with changes in the total cholesterol and LDL levels and with an increased incidence of hypoalbuminemia. We suggest that serum albumin levels should only be used to assess nutritional status in the absence of inflammation and CRP levels ought to be considered in nutritional status interpretation in patients with CKD.
- TG/HDL-c reason, anthropometrics and biochemical indicators of cardiovascular risk in chronic renal in conservative treatment(2017) ALMEIDA, Fortes Alessandra; SENA, Maria Helena Lima Gusmao; GOMES, Santana Tarcisio; RAMOS, Barbosa Lilian; GOBATTO, Luiz Andre Nunes; CONCEICAO, Maria Ester Pereira da; MEDEIROS, Jairza Maria BarretoIntroduction: Cardiovascular diseases (CVD) area major cause of morbidity and mortality, and its prevalence is growing worldwide. Patients with chronic kidney disease (CKD) are at high risk of group, especially those with dyslipidennia. Triglycerides (TG) and high-density lipoprotein (HDL-c) are independent predictors of cardiovascular events. Excessive adipose tissue also increases the cardiovascular risk. Therefore, CVD predictors, such as the Triglycerides / HDL cholesterol (TG / HDL-c) ratio and the anthropometric measurements for assessing body fat are important in clinical practice. Objective: To evaluate the association between TG / HDL ratio, anthropometric measurements and the cardiovascular risk in CKD patients on dialysis. Methods: A cross-sectional study involving 90 clinically stable outpatients. The TG / HDL-c ratio was defined according to a predetermined equation, considering high CVD risk values greater than 2.5 for women and greater than 3.5 for men. The anthropometric parameters used were the body mass index (BMI) and the waist circumference (WC). Social data, lifestyle, clinical and biochemical data were also collected. Results: Fifty patients (55.6%) had a high TG / HDL ratio. Patients with abnormal BMI and WC were at a higher cardiovascular risk, as measured by the TG / HDL-c ratio. There was a statistically significant difference between the anthroponnetric measurements (BMI and the WC), and the TG / HDL-c ratio in the stratified analysis. However, in the adjusted analysis no association between the BMI or the WC and the TG/HDL ratio was observed. Conclusion: There was no association between the TG / HDL-C ratio and the adiposity measurements (BMI and WC) in the adjusted analysis. The results of this study question the real influence of overweight and central obesity in the TG / HDL-c ratio.