ROBERTA LELIS DUTRA
Projetos de Pesquisa
Unidades Organizacionais
LIM/36 - Laboratório de Pediatria Clínica, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
bookPart Síndromes de microdeleção e microduplicação na era dos arrays(2013) JEHEE, Fernanda Maria Sarquis; DUTRA, Roberta Lelis- FGFR4 as a biomarker in squamous cell cancers of mouth and oropharynx(2015) DUTRA, R. L.; SANTOS, M. Dos; MENDES, S. O.; PETERLE, G. T.; LOURO, I. D.; CONFORTI, A. M.Á. Da SilvaHead and neck squamous cell carcinoma (HNSCC) is a malignancy associated with severe mortality despite advances in therapy, and it ranks among the top ten most common cancers worldwide, with a large incidence variation according to sex and geographical location. At the moment, no biomarkers are currently available for HNSCC patients; prognosis depends largely on the stage at presentation, with the most important prognostic factor. Fibroblast growth factor receptors (FGFRs) and ligand binding are among the many molecules that are involved in the tumorigenesis process. These receptors, including FGFR4, belong to the receptor tyrosine kinase family leads to cell growth, mitosis, and differentiation. Mutations and amplifications in FGFR4 have been linked to aggressive tumor progression, and metastasis is associated with poor prognosis in HNSCC. In this review, we summarize the FGF/FGFR complex, signalization mechanisms, and the molecular implications of FGFR4 as potential biomarker for HNSCC. © Springer Science+Business Media Dordrecht 2015.
bookPart Interpretação da variação do número de cópias genômicas identificadas por técnicas citogenômicas(2013) JEHEE, Fernanda Maria Sarquis; DUTRA, Roberta Lelis