JOEL FAINTUCH
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Gastroenterologia, Faculdade de Medicina - Docente
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
- C-Reactive Protein Decrease After Postbariatric Abdominoplasty(2012) CINTRA, Wilson; MODOLIN, Miguel; FAINTUCH, Joel; GEMPERLI, Rolf; FERREIRA, Marcus C.In a prospective study, indices of glucose homeostasis, lipid profile, and systemic inflammation were monitored after an aesthetic abdominoplasty, aiming to scrutinize the possible metabolic benefits for abdominal fat removal. Premenopausal females with substantial weight loss (N = 40) undergoing circumferential abdominoplasty (index group, n = 20) or augmentation mammoplasty with mastopexy (controls, n = 20) were recruited. All of them originally underwent Roux-en-Y gastric bypass. Variables included BMI, white blood cell count, C-reactive protein, hemoglobin, total cholesterol and fractions, triglycerides, glucose, and HbA1c. Follow-up reached 20.3 +/- 13.6 months for index cases and 29.5 +/- 17.4 months for controls. The metabolic and inflammatory indices improved after the bariatric surgery. Subsequent monitoring indicated a stable body weight and biochemical profile in both groups. The exceptions were HDL cholesterol and C-reactive protein, which respectively increased and diminished after the abdominoplasty, consistent with an inflammatory and metabolic advantage for this operation. This is the first long-term study in a weight-stable population to point out such a pattern after abdominoplasty.
- Interference of silicone breast implants on bioimpedance measurement of body fat(2012) YAMAGUCHI, Camila M.; FAINTUCH, Joel; SILVA, Maira M.; MODOLIN, M.; HAYASHI, Silvia Y.; CECCONELLO, I.Background: No study targeting the impact of silicone breast implants on body composition measured by bioimpedance analysis was identified. Objective: Aiming to clarify this question a prospective clinical study was designed. Methods: Adult candidates were submitted to conventional analysis at baseline and two months after the surgical intervention. In addition, unwrapped prostheses were positioned in the axillary cavity before operation and bioimpedance was measured, both with and without application of ultrasound gel for improved conductivity (sham implantation). Results: Patients (N = 20) were young and healthy (26.8 +/- 3.6 years old, BMI 22.1 +/- 3.7 kg/m(2)). In comparison with preoperative results, sham procedures pointed out increased body fat and body resistance (13.2 +/- 5.6 vs 13.6 +/- 5.4 kg, P = 0.017 and 523 +/- 54 vs 569 +/- 53 Omega, P = 0.003, respectively). Two-month follow-up confirmed the same pattern after surgical intervention, with minor discrepancies (13.2 +/- 5.6 vs 13.8 +/- 5.7 kg, P = 0.011 and 523 +/- 54 vs 549 +/- 62 Omega, P = 0.032, respectively). BMI remained stable and did not correlate with bioimpedance changes. Conclusions: Silicone was recognized as adipose tissue. Difference in total body fat (approximately 600 g) was consistent with used amount.
- Systemic Inflammatory Reaction After Silicone Breast Implant(2011) SILVA, Maira M.; MODOLIN, Miguel; FAINTUCH, Joel; YAMAGUCHI, Camila M.; ZANDONA, Cintia B.; CINTRA JR., Wilson; FUJIWARA, Haroldo; CURI, Rui; GEMPERLI, Rolf; FERREIRA, Marcos C.Systemic inflammation after augmentation mammaplasty with modern silicone implants is not currently recognized. In a prospective controlled study, C-reactive protein and other variables were monitored, aiming to test this hypothesis in a young cohort of patients. Females (18-30 years old, BMI = 18.5-30 kg/m(2), N = 52) were consecutively recruited for breast implant (n = 24, Group I) and for abdominal liposuction (n = 28, Group II/Controls). Patients were interviewed at baseline and followed until 6 months after operation. Variables included demographic and clinical information, surgical outcome, inflammatory markers and autoantibodies. Operations were well tolerated, without surgical or infectious complications. Mean prosthesis size was 258 +/- A 21 ml (range = 220-280) and mean aspirate of liposuction was 1972 +/- A 499 ml (range = 1200-3000). Preoperative, 2-month, and 6-month C-reactive protein concentrations for breast implant patients were 1.3 +/- A 1.2, 4.8 +/- A 3.0, and 4.3 +/- A 6.4 mg/l and for liposuction 3.5 +/- A 2.7, 3.5 +/- A 2.1, and 2.2 +/- A 2.2 mg/l, respectively. Change at 2 months was significant (p = 0.001). Autoantibody investigation failed to reveal remarkable aberrations, except for anticardiolipin elevation, which was nearly symmetrical in the two groups. C-reactive protein levels increased after operation and correlated with proinflammatory and procoagulatory indices. A mild increase in anticardiolipin IgM occurred but differences between populations were lacking. Despite excellent cosmetic outcomes and lack of complications, acute phase reaction could signal ongoing immunogenicity of silicone and long-term monitoring is recommended.