JOEL FAINTUCH
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Gastroenterologia, Faculdade de Medicina - Docente
3 resultados
Resultados de Busca
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- Useful Online Resources and Guideline(2022) FAINTUCH, J.; FAINTUCH, J. J.The Internet has become such an omnipresent service, that in the view of many, it has already upgraded from slave to master, and quite a tyrannical one. Whatever the feelings, scientific information would not flow worldwide without the tool, in such unlimited amounts. It is currently estimated that 4.7 billion people use its electronic resources (60% of the planet population). Just the four big names in the field (Google, Amazon, Microsoft and Facebook) store a total of 1200 petabytes of files, each petabyte corresponding to 1015 bytes. If it corresponded to text, only that would represent over 670 billion pages. The MEDLINE database is a more pertinent paradigm as it deals with indexed scientific journals. Other publications such as books, theses, congress proceedings, nonindexed journals, court minutes and press reports are with few exceptions uncovered. It still contains close to 30 million articles or over 300 million pages. Given that a human being rarely reads more than 700 pages/week (a reasonably thick book), that would signal over 8000 millennia to peruse such files, if all of them were available online. These ruminations could look rather aimless and out of focus, yet they point towards the incontrovertible need for careful curation of the key Internet addresses, so that the interested researcher will minimize wasted time and likely find helpful material. That is the objective of the chapter listing a choice of useful sites as well as general Internet resources, nearly all of them costless. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
- Past and Current Status of Scientific, Academic, and Research Fraud(2022) FAINTUCH, J.; FAINTUCH, S.In the quest to advance knowledge, researchers publish approximately 2 million scientific articles each year, in close to 30,000 peer-reviewed journals. Even though there was hardly a time when science was more questioned, distorted, and defamed, this is still the closest thing to the established body of knowledge for universities, academic laboratories, and other government and private organizations and agencies worldwide. Are plagiarism, fraud, and misconduct indeed infiltrating and rotting the revered shrines of wisdom? Or is alleged scientific decay a consequence of relatively few overambitious, incompetent, or truly rogue researchers, who sooner or later are identified and banned from the community? In the distant past, fraud was often in the eye of the beholder. As experimental design was rarely adequate, measuring instruments were primitive or nonexistent, and modern statistics were lacking, conflicts were often decided by the strongest side, namely, the one backed by the authorities, not necessarily the correct one. Fortunately, much institutional advance has occurred, and current fraudsters exceptionally get away with it. This chapter briefly reviews the state of the art in academic research. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
- Microbiome systems biology advancements for natural well-being(2022) CHATTERJEE, Gargi; NEGI, Sangeeta; BASU, Supratim; FAINTUCH, Joel; O'DONOVAN, Anthonia; SHUKLA, PratyooshThroughout the years all data from epidemiological, physiological and omics have suggested that the microbial communities play a considerable role in modulating human health. The population of microorganisms residing in the human intestine collectively known as microbiota presents a genetic repertoire that is higher in magnitude than the human genome. They play an essential role in host immunity and neuronal signaling. Rapid enhancement of sequence based screening and development of humanized gnotobiotic model has sparked a great deal of interest among scientists to probe the dynamic interactions of the commensal bacteria. This review focuses on systemic analysis of the gut microbiome to decipher the complexity of the host-microbe intercommunication and gives a special emphasis on the evolution of targeted precision medicine through microbiome engineering. In addition, we have also provided a comprehensive description of how interconnection between metabolism and biochemical reactions in a specific organism can be obtained from a metabolic network or a flux balance analysis and combining multiple datasets helps in the identification of a particular metabolite. The review highlights how genetic modification of the critical components and programming the resident microflora can be employed for targeted precision medicine. Inspite of the ongoing debate on the utility of gut microbiome we have explored on the probable new therapeutic avenues like FMT (Fecal microbiota transplant) can be utilized. This review also recapitulates integrating human-relevant 3D cellular models coupled with computational models and the metadata obtained from interventional and epidemiological studies may decipher the complex interactome of diet-microbiota-disease pathophysiology. In addi- tion, it will also open new avenues for the development of therapeutics derived from microbiome or implementation of personalized nutrition. In addition, the identification of biomarkers can also help towards the development of new diagnostic tools and eventually will lead to strategic management of the disease. Inspite of the ongoing debate on the utility of the gut microbiome we have explored how probable new therapeutic avenues like FMT (Fecal microbiota transplant) can be utilized. This review also summarises integrating human-relevant 3D cellular models coupled with computational models and the metadata obtained from interventional and epidemiological studies may decipher the complex interactome of diet- microbiota-disease pathophysiology. In addition, it will also open new avenues for the development of therapeutics derived from the microbiome or implementation of personalized nutrition. In addi- tion, the identification of biomarkers can also help towards the development of new diagnostic tools and eventually will lead to strategic management of disease.