IRAI SANTANA DE OLIVEIRA

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Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina - Médico

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  • article 15 Citação(ões) na Scopus
    Ultrasmall superparamagnetic iron oxide nanoparticle uptake as noninvasive marker of aortic wall inflammation on MRI: proof of concept study
    (2018) HEDGIRE, Sandeep; KREBILL, Cicely; WOJTKIEWICZ, Gregory R.; OLIVEIRA, Irai; GHOSHHAJRA, Brian B.; HOFFMANN, Udo; HARISINGHANI, Mukesh G.
    Objective: Radiation therapy for cancer can lead to atherosclerosis by inducing inflammatory changes in the vascular wall. It is difficult to quantitatively measure inflammation on CT and MRI studies. The purpose of this study was to assess the use of ferumoxytol, an ultrasmall superparamagnetic iron oxide nanoparticle, as a noninvasive marker of vessel wall inflammation secondary to radiation therapy in pancreatic cancer patients in comparison with healthy volunteers. Methods: MRI of upper abdomen (T-1, T-2, multi echo T-2* weighted imaging) was performed on 3 T magnet before and 48 h after intravenous administration of ferumoxytol in pancreatic cancer patients who underwent radiation therapy (n = 8) and in healthy volunteers (n = 8). R-2* value was obtained by drawing regions of interest outlining the aortic wall directly on the T-2* medic image and subsequently transposed to the R-2* image using Amira software (v. 5.3.2, FEI, Bordeaux, France). The change in R-2* values was analyzed by student's t-test. Results: The average change in R-2* value of the pancreatic cancer patients was determined to be 216.1ms(-1). The average change R-2* value of the control patients was determined to be 54.6 ms(-1). Thus, pancreatic cancer patients following radiation therapy had a greater uptake of ferumoxytol (p = 0.0082) in their aortic wall as compared to healthy controls. Conclusion: This proof of concept study suggests that greater uptake of ferumoxytol in the aortic wall in cancer patients without visible atherosclerosis may be the expression of increased inflammation. Advances in knowledge: Ultrasmall superparamagnetic iron oxide enhanced MRI can offer an imaging biomarker for quantitative estimation of aortic inflammation preceding atherosclerosis.
  • article 3 Citação(ões) na Scopus
    Liver Surgery: Important Considerations for Pre- and Postoperative Imaging
    (2022) FARIA, Luisa Leitao de; DARCE, George Felipe; BORDINI, Andre Leopoldino; HERMAN, Paulo; JEISMANN, Vagner Birk; OLIVEIRA, Irai Santana de; ORTEGA, Cinthia D.; ROCHA, Manoel de Souza
    Liver surgery may be a curative treatment option not only for primary liver neoplasms but also for liver metastases in selected patients. The number of liver surgeries performed worldwide has increased, but surgical morbidity associated with these surgeries remains significant. Therefore, radiologists need to understand the terminology, surgical techniques, resectability and unresectability criteria, and possible postoperative complications as these are part of the decision-making process. Because vascular and biliary variations are common, an adequate preoperative anatomic evaluation determines the best surgical technique, helps identify patients in whom additional surgical steps will be required, and reduces the risk of inadvertent injury. The surgeon must ensure that the future liver remnant is sufficient to maintain adequate function, aided by the radiologist who can provide valuable information such as the presence of steatosis, biliary dilatation, signs of cirrhosis, and portal hypertension, in addition to the volume of the future liver remnant. Postoperative complications must also be understood and evaluated. The most common postoperative complications are vascular (bleeding, thrombosis, and ischemia), biliary (fistulas, bilomas, and strictures), infectious (incisional or deep), those related to liver failure, and even tumor recurrence. An invited commentary byWinslow is available online. (C) RSNA, 2022
  • bookPart
    Hepatopatias difusas
    (2017) LEãO FILHO, Hilton Muniz; OLIVEIRA, Iraí
  • bookPart
    Baço
    (2017) OLIVEIRA, Iraí
  • conferenceObject
    HEPATIC ANGIOMYOLIPOMAS: CLINICAL AND IMAGING FINDINGS
    (2023) SILVEIRA, Sergio; TUSTUMI, Francisco; DARCE, George F.; JEISMANN, Vagner B.; FONSECA, Gilton M.; KRUGER, Jaime Arthur Pirola; MAKDISSI, Fabio Ferrari; OLIVEIRA, Irai Santana de; ROCHA, Manoel de Souza; COELHO, Fabricio F.; HERMAN, Paulo
  • bookPart