NEWTON KARA JOSE JUNIOR
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/33 - Laboratório de Oftalmologia, Hospital das Clínicas, Faculdade de Medicina
LIM/33 - Laboratório de Oftalmologia, Hospital das Clínicas, Faculdade de Medicina
15 resultados
Resultados de Busca
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- Analysis of ocular cyclotorsion in lying position after peribulbar block and topical anesthesia(2014) KARA-JUNIOR, Newton; MOURAD, Paula C.; MORAES, Renata L. B.; MORAES, Renata L. B.; PIVA, Caroline; SANTHIAGO, Marcony RodriguesPurpose: Evaluate the magnitude of cyclotorsion during cataract surgery in patients with indication for intraocular toric lenses comparing the results after peribulbar and after topical anesthesia. Methods: This prospective study comprised 112 eyes that underwent cataract surgery with implantation of toric intraocular lens by topical anesthesia or peribulbar block. We estimated how many degrees of cyclotorsion occurred after topical anesthesia and peribulbar block with the patient in supine position. A tag was performed in the position of 180 degrees of the right eye and zero degrees of the left eye, with the patient seated. Afterwards, it was requested a change to the supine position and then a new dial in 180 and zero degrees respectively from right and left eye were made. Results: The current study demonstrated that patients submitted to cataract surgery with implantation of toriclens under local anesthesia showed approximately 6.89 degrees of incyclotorsion (82 eyes) and 6.93 degrees of excyclotorsion (38 eyes) and a mean of cyclotorsion of 6.91 degrees. Patients undergoing peribulbar block showed 5.68 degrees of incyclotorsion (73 eyes) and 4.81 degrees of excyclotorsion (47 eyes) and a mean of cyclotorsion of 4.92 degrees. Conclusion: Through the study we can see that the movement of incyclotorsion in patients undergoing peribulbar anesthesia was lower when compared to topical anesthesia. This is relevant since the greater the incyclotorsion, the lower the predictability of the surgery and the lower the chance of obtaining excellent results in the final refractometric.
- Medicina baseada em evidências(2014) KARA-JUNIOR, Newton
- Como mensurar a precisão dos resultados de estudos clínicos(2014) KARA-JUNIOR, Newton
- Analgesia preemptiva com nepafenaco 0,1% na fotocoagulação da retina(2014) CASTRO, Emerson Fernandes de Sousa e; OKUDA, Erika Araki; AMATTO, Vinícius Balbi; ALMEIDA, Hirlana Gomes; GRACIA, Marina; KARA-JUNIOR, NewtonObjetivo: Avaliar o efeito preemptivo com nepafenaco 0,1% em pacientes submetidos à fotocoagulação da retina para tratamento da retinopatia diabética proliferativa. Métodos: Trinta pacientes foram submetidos à fotocoagulação com laser de argônio em ambos os olhos. O olho contralateral de cada paciente foi o controle. O nepafenaco e o placebo foram utilizados 30 minutos antes da aplicação do laser. Ambos os olhos foram fotocoagulados no mesmo dia. A intensidade da dor foi avaliada por meio da escala analógica visual e da escala descritiva de dor. Resultados: A análise da interação instilação versus nepafenaco mostrou que os pacientes do grupo placebo apresentaram níveis de dor semelhantes em ambos os olhos, e os do grupo nepafenaco apresentaram redução importante do nível de dor no olho em que foi instilado a suspensão de 0,1% quando comparado ao olho contralateral que recebeu placebo (p=0,023). Conclusão: Este estudo sugere que a suspensão de 0,1% de nepafenaco foi útil na analgesia preemptiva de pacientes submetidos à fotocoagulação de retina quando comparada ao placebo.
- Applications of visual evoked potentials and Fourier-domain optical coherence tomography in Parkinson's disease: a controlled study(2014) QUAGLIATO, Lucas Barasnevicius; DOMINGUES, Carolina; QUAGLIATO, Elizabeth Maria Aparecida Barasnevicius; ABREU, Elvira Barbosa De; KARA-JUNIOR, NewtonPurpose: The goal of this cross-sectional observational study was to quantify the pattern-shift visual evoked potentials (VEP) and the thickness as well as the volume of retinal layers using optical coherence tomography (OCT) across a cohort of Parkinson's disease (PD) patients and age-matched controls. Methods: Forty-three PD patients and 38 controls were enrolled. All participants underwent a detailed neurological and ophthalmologic evaluation. Idiopathic PD cases were included. Cases with glaucoma or increased intra-ocular pressure were excluded. Patients were assessed by VEP and high-resolution Fourier-domain OCT, which quantified the inner and outer thicknesses of the retinal layers. VEP latencies and the thicknesses of the retinal layers were the main outcome measures. Results: The mean age, with standard deviation (SD), of the PD patients and controls were 63.1 (7.5) and 62.4 (7.2) years, respectively. The patients were predominantly in the initial Hoehn-Yahr (HY) disease stages (34.8% in stage 1 or 1.5, and 55.8 % in stage 2). The VEP latencies and the thicknesses as well as the volumes of the retinal inner and outer layers of the groups were similar. A negative correlation between the retinal thickness and the age was noted in both groups. The thickness of the retinal nerve fibre layer (RNFL) was 102.7 mu m in PD patients vs. 104.2 mu m in controls. Conclusions: The thicknesses of retinal layers, VEP, and RNFL of PD patients were similar to those of the controls. Despite the use of a representative cohort of PD patients and high-resolution OCT in this study, further studies are required to establish the validity of using OCT and VEP measurements as the anatomic and functional biomarkers for the evaluation of retinal and visual pathways in PD patients.
- Intraocular pressure in chronic users of low-dose oral corticosteroids for connective tissue disease(2014) GOMES, Beatriz Fiuza; MORAES JR., Haroldo Vieira; KARA-JUNIOR, Newton; AZEVEDO, Mario Newton L. de; LIMA, Fernanda Bina Fonyat de; SANTHIAGO, Marcony R.Objective: To investigate the mean intraocular pressure (IOP) of patients with connective tissue disease (CTD) on low-dose chronic systemic corticosteroid therapy and compare with control subjects. Design: Cross-sectional comparative study. Participants: A total of 86 patients with CTD were grouped according to corticosteroid therapy. Group 1 (n = 27) was composed of patients with CTD receiving low-dose systemic corticosteroid therapy (<10 mg prednisone or its equivalent oral corticosteroid) for at least 6 months, and group 2 (n = 59) included patients with CTD without use of corticosteroid therapy. Group 3 (n = 20) was composed of healthy control subjects. Methods: All patients underwent a complete ophthalmic evaluation by an experienced investigator and had their clinical records reviewed by another independent investigator. IOP was measured by Goldmann applanation tonometry. Results: In all 3 groups, the IOPs were within the normal range. The mean IOP was 13.1 +/- 2.7 mm Hg (range 8-19 mm Hg) in the CTD corticosteroid group (group 1), 13.7 +/- 2.7 mm Hg (range 9-22 mm Hg) in CTD group without corticosteroid therapy (group 2), and 13.1 +/- 1.6 mm Hg (range 10-16 mm Hg) in the control group (group 3). No significant differences in IOP were observed among the 3 groups (p = 0.50). Conclusions: Patients under chronic treatment with low-dose systemic corticosteroid therapy for CTD presented with IOP within the normal range, not clinically significant different from the IOP of patients with CTD without any steroid therapy or from healthy control subjects.
- Definição da população e randomização da amostra em estudos clínicos(2014) KARA-JUNIOR, Newton
- The challenge for ""multilingual"" scientists in Brazil(2014) KARA-JUNIOR, Newton; AMBROSIO JR., Renato; CHAMON, Wallace; LEME, Luiz Eugenio Garcez
- Reflexões sobre elaboração e publicação de pesquisas clínicas(2014) JOSÉ JUNIOR, Newton Kara
- Comparação das características de citação entre os relatos de caso/séries de casos versus demais desenhos de estudos nos artigos publicados em periódicos brasileiros de Oftalmologia(2014) LIRA, Rodrigo Pessoa Cavalcanti; AMORIM, Fernando Henrique Ramos; GONÇALVES, Fauze Abdulmassih; ARIETA, Carlos Eduardo Leite; KARA-JUNIOR, NewtonObjective: To compare the citation characteristics of the case reports and the case series versus the other study designs of articles published, in 2008-2009, in Brazilian journals of ophthalmology indexed in Science Citation Index Expanded (SCIE). Methods: This study was a systematic review. Original articles were identified by review of documents published at the two Brazilians ophthalmology journals indexed at SCIE (""Arquivos Brasileiros de Oftalmologia"" and ""Revista Brasileira de Oftalmologia""). All documents (""articles"" and ""reviews"") listed at SCIE from January 1, 2008 to December 31, 2009 were included, except: ""editorial materials""; ""corrections""; ""letters""; and ""biographical items"". The outcomes were the distributions, the number of citations (through the end of second year after publication date), the mean of the number of citations, and the likelihood of citation (cited at least once vs. no citation), according the study design of the article. Results: The search at the Web of Science revealed 382 articles. The distribution of articles according to study design was: Case Reports 106 articles (27.7%) Case Series 50 (13.1%), Sectional Studies 92 (24.1%), Clinical Trials, Phase I or Phase II 40 (10.5%), Clinical Trials, Phase III or Phase IV 29 (7.6%), Non-Systematic Reviews 33 (8.6%) and Experimental Studies 32 (8.4%). The citation count was statistically lower (P < .001) in the Case Reports/Case Series (0.55 - SD 1.05) compared with the others study designs (1.04 - SD 1.63). The likelihood citation was statistically lower (P < .001) in the Case Reports/Case Series (49/156 - 31.4%) compared with the others study designs (110/226 - 48.7%). Conclusion: Case reports and case series showed lower number of citations and likelihood citation than others study designs. The results of this study suggest that the editorial boards should publish only original or very rare Case Reports / Case Series with clinical significance or implications. This effort will bring benefits to the researcher, to the ophthalmologist who is looking for updating, and to the journal itself