ANTONIO EDUARDO ZERATI
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/02 - Laboratório de Anatomia Médico-Cirúrgica, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/02 - Laboratório de Anatomia Médico-Cirúrgica, Hospital das Clínicas, Faculdade de Medicina - Líder
2 resultados
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- Physical Activity Levels in Peripheral Artery Disease Patients(2019) GERAGE, Aline Mendes; CORREIA, Marilia de Almeida; OLIVEIRA, Paulo Mesquita Longano de; PALMEIRA, Aline Cabral; DOMINGUES, Wagner Jorge Ribeiro; ZERATTI, Antonio Eduardo; PUECH-LEAO, Pedro; WOLOSKER, Nelson; RITTI-DIAS, Raphael Mendes; CUCATO, Gabriel GrizzoBackground. Increases in daily physical activity levels is recommended for patients with peripheral artery disease (PAD). However, despite this recommendation, little is known about the physical activity patterns of PAD patients. Objective: To describe the physical activity patterns of patients with symptomatic peripheral artery (PAD) disease. Methods; This cross-sectional study included 174 PAD patients with intermittent claudication symptoms. Patients were submitted to clinical, hemodynamic and functional evaluations. Physical activity was objectively measured by an accelerometer, and the time spent in sedentary, low-light, high-light and moderate-vigorous physical activities (MVPA) were obtained. Descriptive analysis was performed to summarize patient data and binary logistic regression was used to test the crude and adjusted associations between adherence to physical activity recommendation and sociodemographic and clinical factors. For all the statistical analyses, significance was accepted at p < 0.05. Results: Patients spent in average of 640 +/- 121 min/day, 269 +/- 94 min/day, 36 +/- 27 min/day and 15 +/- 16 min/day in sedentary, low-light, high-light and MVPA, respectively. The prevalence of patients who achieved physical activity recommendations was 3.4%. After adjustment for confounders, a significant inverse association was observed between adherence to physical activity recommendation and age (OR = 0.925; p = 0.004), while time of disease, ankle brachial index and total walking distance were not associated with this adherence criteria (p > 0.05). Conclusion: The patterns of physical activity of PAD patients are characterized by a large amount of time spent in sedentary behaviors and a low engagement in MVPA. Younger patients, regardless of the clinical and functional factors, were more likely to meet the current physical activity recommendations.
- Walking Training Improves Ambulatory Blood Pressure Variability in Claudication(2021) CHEHUEN, Marcel da Rocha; CUCATO, Gabriel Grizzo; CARVALHO, Celso Ricardo Fernandes de; ZERATI, Antonio Eduardo; LEICHT, Anthony; WOLOSKER, Nelson; RITTI-DIAS, Raphael Mendes; FORJAZ, Claudia Lucia de MoraesBackground: Walking training (WT) improves walking capacity and reduces clinic blood pressure (BP) in patients with peripheral artery disease (PAD), but its effects on ambulatory BP remains unknown. Objectives: To investigate the effect of 12 weeks of WT on ambulatory BP and its variability in patients with PAD. Methods: Thirty-five male patients with PAD and claudication symptoms were randomly allocated into two groups: control (n = 16, 30 min of stretching) and WT (n = 19, 15 bouts of 2 min of walking at the heart rate of leg pain threshold interspersed by 2 min of upright rest). Before and after 12 weeks, 24-hour ambulatory BP was assessed. Ambulatory BP variability indices assessed at both time points included the 24-hour standard deviation (SD 24), the awake and asleep weighted standard deviation (SD dn), and the 24-hour average real variability (ARV 24). Data were analyzed by mixed two-way ANOVAs, considering P<0.05 as significant. Results: After 12 weeks, neither group had significant changes in 24-hour, awake and sleep BPs. The WT decreased systolic and mean BP variabilities (Systolic BP - 13.3 +/- 2.8 vs 11.8 +/- 2.3, 12.1 +/- 2.84 vs 10.7 +/- 2.5 and 9.4 +/- 2.3 vs 8.8 +/- 2.2 mmHg); Mean BP - 11.0 +/- 1.7 vs 10.4 +/- 1.9, 10.1 +/- 1.6 vs 9.1 +/- 1.7 and 8.0.+/- 1.7 vs 7.2 +/- 1.5 mmHg) for SD 24, SD dn and ARV 24, respectively). Neither group had significant changes in diastolic BP variabilities after 12 weeks. Conclusion: The WT does not change ambulatory BP levels but decreases ambulatory BP variability in patients with PAD. This improvement may have a favorable impact on the cardiovascular risk of patients with symptomatic PAD.