MAURICIO DENER CORDEIRO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina
15 resultados
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- Renal cell carcinoma with perirenal fat invasion: Is partial nephrectomy as good as radical surgery?(2017) CORDEIRO, Mauricio; BASTOS, Diogo Assed; GALLUCCI, Fabio Pescarmona; BARBOSA, Joao Arthur Brunhara; ILARIO, Eder Nisi; CARVALHO, Paulo Afonso De; NONEMACHER, Henrique T. S.; ALBUQUERQUE, George Lins; MATTEDI, Romulo Loss; CARVALHO, Arnaldo Fazoli; NAHAS, William Carlos
- Neutrophil-to-Lymphocyte Ratio Predicts Cancer Outcome in Locally Advanced Clear Renal Cell Carcinoma(2022) CORDEIRO, Mauricio Dener; ILARIO, Eder Nisi; ABE, Daniel Kanda; CARVALHO, Paulo Afonso de; MUNIZ, David Queiroz Borges; SARKIS, Alvaro Sadek; COELHO, Rafael Ferreira; GUIMARAES, Ronaldo Morales; HADDAD, Michel Vitor; NAHAS, William CarlosBackground: To evaluate the association of neutrophil-to-lymphocyte ratio (NLR) with recurrence-free survival (RFS) and overall survival (OS) in patients with locally advanced nonmetastatic clear cell renal cell carcinoma (ccRCC) under-going radical nephrectomy. Material and Methods: We retrospectively identified 880 nephrectomies performed between January 2009 and December 2016 in a single center, reviewed data from 478 radical nephrectomies for kidney tumors and identified 187 patients with locally advanced nonmetastatic ccRCC (pT3-T4 N0M0). NLR was obtained preoperatively and calculated by dividing absolute neutrophil count by absolute lymphocyte count. OS and RFS were evaluated by the Kaplan-Meier method. Cox proportional-hazards regression models were used to evaluate predictors of RFS and OS. Results: Among 187 patients with ccRCC (mean age 63.4 +/- 11.5 years; 118 [63.1%] male), the median follow-up was 48.7 months. On univariate analysis, in patients with Fuhrman nuclear grade of differentiation 3-4, the median time to recurrence was significantly shorter with NLR >= 4 than < 4 (24 vs. 55 months, P = .045). On multivariable analysis adjusted for NLR >= 4, among all variables analyzed (NLR, microvascular invasion, sarcomatoid differentiation, tumor size and body mass index), only nuclear grade of differentiation was an independent predictor of recurrence (hazard ratio 2.18; 95% confidence interval 1.07-4.92, P = .03). The 3-year OS had no statistically significant difference between patients with NLR >= 4 or < 4. Conclusion: For patients with locally advanced, nonmetastatic ccRCC, RFS was reduced with high nuclear grade of differentiation and high preoperative NLR. These findings suggest an association between higher NLR and worse outcomes in locally advanced ccRCC.
- Robotic-assisted radical cystectomy: the first multicentric Brazilian experience(2020) MOSCHOVAS, Marcio Covas; CHADE, Daher Cesar; ARAP, Marco Antonio; SARKIS, Alvaro Sadek; NAHAS, William Carlos; TANURE, Luiz Henrique Rodrigues; EBAID, Gustavo; FAZOLI, Arnaldo Jose de Carvalho; GUGLIELMETTI, Giuliano Betoni; BISTACCO, Carolina; CORDEIRO, Mauricio; AFONSO, Paulo; SIGHINOLFI, Maria Chiara; ROCCO, Bernardo; COELHO, Rafael FerreiraThe objective of this study is to report the first multicentric Brazilian series and learning curve of robotic radical cystectomy (RARC) with related intra- and postoperative outcomes. We retrospectively analyzed 37 RARC prospectively collected at four different centers in Brazil, from 2013 to 2019. We analyzed the patient's demographics, pathological tumor, and nodal status, as well as intra- and postoperative outcomes. Statistical analysis was performed with the IBM (SPSS version 25) software. Overall, 86% were male, and the median age was 69 years. 83% had muscle-invasive bladder cancer, and 17% a high-grade, recurrent non-muscle-invasive tumor. The median operative time was 420 min with 300 min as console time. Median blood loss was 350 ml and transfusion rate was 10%. In 68% of the cases, we performed an intracorporeal Bricker urinary diversion, 24% intracorporeal neobladder, and 8% ureterostomy. Six patients (16%) had a Clavien 1-2, 8% had Clavien 3, 2.5% had a Clavien 4, and 5% had Clavien 5. The median length of hospital stay was 7 days. The final pathological exam pointed out pT0 in 16%, pT1 in 8%, pT2 in 32%, >= pT3 in 27%, and 16% pTis. 95% had negative surgical margins. The survival at 30, 90, and 180 days was 98%, 95%, and 95%, respectively. To our knowledge, this is the first multicentric series of RARC reporting the learning curve in Brazil; even if still representing a challenging procedure, RARC could be safely and effectively faced by experienced surgeons at centers with high volumes of robotic surgery.
- MCT1 expression is independently related to shorter cancer-specific survival in clear cell renal cell carcinoma(2021) CARVALHO, Paulo Afonso de; BONATELLI, Murilo; CORDEIRO, Mauricio Dener; COELHO, Rafael Ferreira; REIS, Sabrina; SROUGI, Miguel; NAHAS, Willian Carlos; PINHEIRO, Celine; LEITE, Katia Ramos MoreiraClear cell renal cell carcinoma (ccRCC) has been considered a metabolic disease, with loss of von Hippel-Lindau (VHL) gene and consequent overexpression of hypoxia-inducible factor 1 alpha (HIF-1a), which is central for tumor development and progression. Among other effects, HIF-1a is involved in the metabolic reprogramming of cancer cells towards the Warburg effect involved in tumor cell proliferation, migration and survival. In this context, several proteins are expressed by cancer cells, including glucose and lactate transporters as well as different pH regulators. Among them, monocarboxylate transporters (MCTs) can be highlighted. Our aim is to comprehensively analyze the immunoexpression of MCT1, MCT2, MCT4, CD147, CD44, HIF-1 alpha, GLUT1 and CAIX in ccRCC surgical specimens correlating with classical prognostic factors and survival of patients with long follow-up. Surgical specimens from 207 patients with ccRCC who underwent radical or partial nephrectomy were used to build a tissue microarray. Immunostaining was categorized into absent/weak or moderate/strong and related to all classic ccRCC prognostic parameters. Kaplan-Meier curves were generated to assess overall and cancer-specific survival, and multivariate analysis was performed to identify independent prognostic factors of survival. Multivariate analysis showed that MCT1 together with tumor size and TNM staging, were independently related to cancerspecific survival. MCT1, CD147, CD44 and GLUT1 expression were significantly associated with poor prognostic factors. We show that MCT1 is an independent prognostic factor for cancer-specific survival in ccRCC justifying the use of new target therapies already being tested in clinical trials.
- Oncological outcomes of positive surgical margins in partial nephrectomy for renal cell carcinoma.(2017) NONEMACHER, Henrique T. S.; CORDEIRO, Mauricio; ALBUQUERQUE, George Lins De; GALUCCI, Fabio; CARVALHO, Paulo Afonso de; BORGES, Leonardo; GUGLIELMETTI, Giuliano Betuni; BASTOS, Diogo Assed; COELHO, Rafael; SARKIS, Alvaro; DZIK, Carlos; NAHAS, William Carlos
conferenceObject ONCOLOGICAL OUTCOMES OF POSITIVE SURGICAL MARGINS IN PATIENTS WHO UNDERWENT PARTIAL NEPHRECTOMY FOR RENAL CELL CARCINOMA.(2017) NONEMACHER, Henrique; CORDEIRO, Mauricio; ALBUQUERQUE, George Lins de; BRUNHARA, Joao; CARVALHO, Paulo Afonso; GALLUCCI, Fabio; BORGES, Leornardo; COELHO, Rafael; PATEL, Vipul; NAHAS, WillianconferenceObject NEPHROMETRY SCORES ARE USELESS FOR EXPERIENCED UROLOGISTS IN CLINICAL PRACTICE(2017) NONEMACHER, Henrique; GUGLIELMETTI, Giuliano; ALBUQUERQUE, George Lins de; COELHO, Rafael; CORDEIRO, Mauricio; FAZOLI, Arnaldo; CARVALHO, Paulo Afonso; FREIRE, Tiago Magalhaes; HAYEK, Kayann Kaled R. el; PAGOTTO, Vitor; ALBUQUERQUE, George Lins de; ROCHA, Bruno Aragao; RODRIGUES, Diego Parga; KANAS, Alexandre Fligelman; VIANA, Publio Cesar Cavalcanti; NAHAS, WillianconferenceObject CAN WE IMPROVE PROGNOSTIC DISCRIMINATION FOR PATIENTS WITH PT3A STAGE RENAL TUMORS?(2018) CAVALCANTE, Alexandre; CORDEIRO, Mauricio; GALLUCCI, Fabio P.; NONEMACHER, Henrique; CARVALHO, Paulo Afonso; NAHAS, William- Retrograde Release of the Neurovascular Bundle with Preservation of Dorsal Venous Complex During Robot -assisted Radical Prostatectomy: Optimizing Functional Outcomes(2020) CARVALHO, Paulo Afonso de; BARBOSA, Joao A. B. A.; GUGLIELMETTI, Giuliano B.; CORDEIRO, Mauricio Dener; ROCCO, Bernardo; NAHAS, William C.; PATEL, Vipul; COELHO, Rafael Ferreira
conferenceObject Neutrophil-to-lymphocyte ratio as a predictor of oncologic outcomes in locally advanced non-metastatic clear cell renal carcinoma(2020) RODRIGUES, Gilberto; SIERRA, Pablo; ALBUQUERQUE, Emanuel; GALLUCCI, Fabio Pescarmona; ILARIO, Eder Nisi; CARVALHO, Paulo Afonso de; MUNIZ, David Queiroz Borges; SARKIS, Alvaro; COELHO, Rafael; CORDEIRO, Mauricio; NAHAS, William Carlos