RICARDO DOS SANTOS SIMOES

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Lattes
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Instituto Central, Hospital das Clínicas, Faculdade de Medicina
SCGINEC-62, Hospital Universitário
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina

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Autor: FLORENCIO-SILVA, Rinaldo ×

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  • conferenceObject
    Expression of vascular endothelial growth factor (VEGF) in the endometrium of women with polycystic ovary syndrome (PCOS)
    (2013) SIMOES, Ricardo S.; SASSO, Gisela R.; FLORENCIO-SILVA, Rinaldo; MAGANHIN, Carla C.; SOARES- JR., Jose M.; BARACAT, Maria Candida P.; BARACAT, Edmund C.
  • conferenceObject
    Melatonin may influence CYP19 immunoexpression in ovary of female rats in proestrous phase
    (2013) SASSO, Gisela R.; MAGANHIN, Carla C.; FUCHS, Luizf.; FRANCO, Paulo Celso; FLORENCIO-SILVA, Rinaldo; SIMOES, Ricardo S.; BARACAT, Edmund C.; SOARES- JR., Jose M.
  • conferenceObject
    Melatonin may influence the immunoexpression of proteins and the up-and-down regulation of ovarian functions related genes in the ovary of pseudopinealectomized rats in proestrous phase
    (2013) SOARES- JR., Jose Maria; MAGANHIN, Carla C.; SASSO, Gisela R.; FLORENCIO-SILVA, Rinaldo; SIMOES, Ricardo S.; SIMOES, Manuel J.; BARACAT, Edmund C.
  • conferenceObject
    Effect of melatonin, metformin and clomiphene citrate in ovary of rats in the permanent estrus
    (2014) LOMBARDI, Leonardo A.; MAGANHIN, Carla C.; MATTOS, Leandro S.; SASSO, Gisela R.; SIMOES, Ricardo S.; FLORENCIO-SILVA, Rinaldo; FONSECA, Caio C.; FRANCO, Paulo C.; SOARES- JR., Jose Maria; SIMOES, Manuel J.
  • article 0 Citação(ões) na Scopus
    Histomorphometric and immunohistochemical changes in interstitial cells and ovarian follicles of rats with polycystic ovaries treated with clomiphene citrate
    (2021) LOMBARDI, Leonardo Augusto; MATTOS, Leandro Sabara; SIMOES, Ricardo Santos; FLORENCIO-SILVA, Rinaldo; SIMOES, Manuel de Jesus; FRANCO, Paulo Celso; CARBONELL, Adriana Aparecida Ferraz; SASSO, Gisela Rodrigues da Silva; BARACAT, Edmund Chada; SOARES-JR, Jose Maria
    Objective To evaluate the histomorphometric and immunohistochemical changes in interstitial cells and ovarian follicles of rats treated with clomiphene citrate during and after induction of permanent estrus. Methods Twenty four adult-female rats with regular estrous cycle were equally divided into three groups: (1) GCtrl-at estrous phase. (2) GPCOS-at permanent-estrous phase. (3) GCC-PCOS rats, which remained exposed to 60 days of continuous illumination and treated with Clomiphene Citrate. After that, the animals were euthanized, and the ovaries were removed and processed for paraffin embedding. Sections were stained with H.E. for histomorphometry or subjected to immunohistochemistry for Ki-67 and cleaved caspase-3 detections. Results The GPCOS showed lack of corpus luteum and several ovarian cysts, as well as interstitial-like cells. The presence of corpus luteum and a significant increase in primary and antral follicles were observed in GCC, which also showed a decrease in the number of ovarian cysts and in the area occupied by interstitial-like cells, as well as a decrease in nuclear volume of interstitial cells. The percentage of cell proliferation was significantly higher in granulosa cells of the GCC. On the other hand, the percentage of apoptosis was significantly higher in the granulosa cells of GPCOS than the GCC. Conclusion The ovaries of rats treated with clomiphene citrate showed a decrease in the number of cysts, an increase in the number of ovarian follicles, the presence of corpus luteum along with a decrease in the nuclear volume in the area occupied by interstitial cells.
  • conferenceObject
    Evaluation of the BCL-2/BAX ratio in the endometrium of women with polycystic ovary syndrome (PCOS) and in women during proliferative phase
    (2013) SIMOES, Ricardo S.; SASSO, Gisela R.; FLORENCIO-SILVA, Rinaldo; MAGANHIN, Carla C.; SOARES- JR., Jose M.; BARACAT, Maria Candida P.; BARACAT, Edmund C.
  • conferenceObject
    Folistatin and Inhibin-beta A: Expression and influence ovarian function by the upregulation and downregulation of steroidogenesis related genes in ovary of pinealectomized rats in proestrous phase
    (2014) MAGANHIN, Carla C.; SASSO, Gisela R.; FLORENCIO-SILVA, Rinaldo; CALIO, Michele L.; SIMOES, Ricardo S.; SIMOES, Manuel J.; BARACAT, Edmund C.; SOARES- JR., Jose M.
  • conferenceObject
    Melatonin and metformin effects in bone tissue of rats in the permanent estrous phase
    (2018) SASSO, Gisela R.; FLORENCIO-SILVA, Rinaldo; TEIXEIRA, Cristiane D.; CARBONEL, Adriana F.; FUCHS, Luiz F.; SIMOES, Ricardo D.; SIMOES, Manuel D.
  • conferenceObject
    Effects of soy isoflavones and/or 17beta-estradiol on bone tissue of ovariectomized rats
    (2014) SASSO, Gisela R.; BERTONCINI, Clelia R.; TEIXEIRA, Cristiane D.; FLORENCIO-SILVA, Rinaldo; MAGANHIN, Carla C.; VASCONCELOS, Katia de; SIMOES, Ricardo S.; SIMOES, Manuel J.; SOARES- JR., Jose Maria; CARBONEL, Adriana Aparecida F.
  • article 4 Citação(ões) na Scopus
    The influence of phytoestrogens or estrogens on the proliferation of the rat endocervical mucosa
    (2020) FRANCO, Paulo Celso; SIMOES, Ricardo Santos; CARBONEL, Adriana Aparecida Ferraz; SASSO, Gisela Rodrigues da Silva; FLORENCIO-SILVA, Rinaldo; BARACAT, Edmund Chada; GIRAO, Manoel Batista Castello; SOARES JUNIOR, Jose Maria; SIMOES, Manuel de Jesus
    INTRODUCTION: Although estrogen therapy is widely used against post-menopausal symptoms, it can present adverse effects, including endometrial cancer. Soy isoflavones are considered a possible alternative to estrogen therapy. However, there are still concerns whether isoflavones exert trophic effects on the uterine cervix. OBJECTIVES: To evaluate the histomorphometric and immunohistochemical alterations in the uterine cervix of ovariectomized rats treated with soy isoflavones (Iso). METHODS: Fifteen adult Wistar rats were ovariectomized (Ovx) and divided into three groups: Group I (Ovx), administered with vehicle solution; Group II (OVX-Iso), administered with concentrated extract of Iso (150 mg/kg) by gavage; and Group III (OVX-E2), treated with 17 beta-estradiol (10 mu g/kg), subcutaneously. After 30 days of treatments, the uterine cervix was fixed in 10% formaldehyde and processed for paraffin-embedding. Sections were stained with Hematoxylin and eosin for morphological and morphometric studies or subjected to immunohistochemistry for detections of Ki-67 and vascular endothelial growth factor-A (Vegf-A). The data obtained were subjected to statistical analysis (p <= 0.05). RESULTS: We noted an atrophic uterine cervix in GI, whereas it was more voluminous in GII and even more voluminous in GIII. The thickness of the cervical mucosa was significantly higher in GIII, as compared to GI and GII. The cell proliferation (Ki-67) was significantly elevated in the estradiol and isoflavones treated groups, whereas Vegf-A immunoexpression was significantly higher in GIII, as compared to groups GII and GI. CONCLUSIONS: Soy isoflavones cause less trophic and proliferative effects in the uterine cervix of rats as compared to estrogen.